Application of Speech Processing to a new Generation PABX

An application of speech recognition and synthesis to a new generation electronic PABX is described. Besides and improved man-machine interaction, the introduction in a PABX environment of the speech processing currently available allows an easier and more extensive use of the facilities offered by a current PABX. At FACE-RC a demonstrative system that make use of speaker independent, continuos speech recognizer and speech waveform synthetizer for messaging has been developed. In this paper the technical aspects will be described. It will be noted that an application of speech processing must consider carefully the actual limits of the current technology in order to obtain a successfull implementation

Carborane-Conjugated 2-Quinolinearcarboxamide Ligands of the Translocator Protein for Boron Neutron Capture Therapy

Potential boron neutron capture therapy (BNCT) agents have been designed on the basis of the evidence about translocator protein (TSPO) overexpression on the outer mitochondrial membrane of tumor cells. The structure of the first TSPO ligand bearing a carborane cage (compound 2d) has been modified in order to find a suitable candidate for in vivo studies. The designed compounds were synthesized and evaluated for their potential interaction with TSPO and tumor cells. In vitro biological evaluation showed in the case of fluoromethyl derivative 4b a nanomolar TSPO affinity very similar to that of 2d, a significantly lower cytotoxicity, and a slightly superior performance as boron carrier toward breast cancer cells. Moreover, compound 4b could be used as a 19F magnetic resonance imaging (MRI) agent as well as labeled with 11C or 18F to obtain positron emission tomography (PET) radiotracers in order to apply the “see and treat” strategy in BNCT