91 research outputs found
Avalanche Dynamics in Wet Granular Materials
We have studied the dynamics of avalanching wet granular media in a rotating
drum apparatus. Quantitative measurements of the flow velocity and the granular
flux during avalanches allow us to characterize novel avalanche types unique to
wet media. We also explore the details of viscoplastic flow (observed at the
highest liquid contents) in which there are lasting contacts during flow,
leading to coherence across the entire sample. This coherence leads to a
velocity independent flow depth at high rotation rates and novel robust pattern
formation in the granular surface.Comment: 5 pages, 3 figures in color, REVTeX4, for smaller pdfs see
http://angel.elte.hu/~tegzes/condmat.htm
A Dedicated Promoter Drives Constitutive Expression of the Cell-Autonomous Immune Resistance GTPase, Irga6 (IIGP1) in Mouse Liver
Background: In general, immune effector molecules are induced by infection. Methodology and Principal Findings: However, strong constitutive expression of the cell-autonomous resistance GTPase, Irga6 (IIGP1), was found in mouse liver, contrasting with previous evidence that expression of this protein is exclusively dependent on induction by IFNc. Constitutive and IFNc-inducible expression of Irga6 in the liver were shown to be dependent on transcription initiated from two independent untranslated 59 exons, which splice alternatively into the long exon encoding the full-length protein sequence. Irga6 is expressed constitutively in freshly isolated hepatocytes and is competent in these cells to accumulate on the parasitophorous vacuole membrane of infecting Toxoplasma gondii tachyzoites. Conclusions and Significance: The role of constitutive hepatocyte expression of Irga6 in resistance to parasites invading from the gut via the hepatic portal system is discussed
Reconstruction of cellular variability from spatiotemporal patterns of Dictyostelium discoideum
Variability in cell properties can be an important driving mechanism behind spatiotemporal patterns in biological systems, as the degree of cell-to-cell differences determines the capacity of cells to locally synchronize and, consequently, form patterns on a larger spatial scale. In principle, certain features of spatial patterns emerging with time may be regulated by variability or, more specifically, by certain constellations of cell-to-cell differences. Similarly, measuring variability in a system (i.e. the spatial distribution of cell-cell differences) may help predict properties of later-stage patterns
Cell-autonomous and environmental contributions to the interstitial migration of T cells
A key to understanding the functioning of the immune system is to define the mechanisms that facilitate directed lymphocyte migration to and within tissues. The recent development of improved imaging technologies, most prominently multi-photon microscopy, has enabled the dynamic visualization of immune cells in real-time directly within intact tissues. Intravital imaging approaches have revealed high spontaneous migratory activity of T cells in secondary lymphoid organs and inflamed tissues. Experimental evidence points towards both environmental and cell-intrinsic cues involved in the regulation of lymphocyte motility in the interstitial space. Based on these data, several conceptually distinct models have been proposed in order to explain the coordination of lymphocyte migration both at the single cell and population level. These range from “stochastic” models, where chance is the major driving force, to “deterministic” models, where the architecture of the microenvironment dictates the migratory trajectory of cells. In this review, we focus on recent advances in understanding naïve and effector T cell migration in vivo. In addition, we discuss some of the contradictory experimental findings in the context of theoretical models of migrating leukocytes
A neuropathology-based approach to epilepsy surgery in brain tumors and proposal for a new terminology use for long-term epilepsy-associated brain tumors
Retrospective analysis of 104 histologically proven adult brainstem gliomas: clinical symptoms, therapeutic approaches and prognostic factors
The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functions
The system of equations for the ion sound and Langmuir waves and its new exact solutions
The present study deals with the system of equations for the ion sound and Langmuir waves (SEISLWs). Distinct integration schemes, including the modified Kudraysov method (MKM) and the hyperbolic function method (HFM) with the help of symbolic computation package, are utilized to acquire new exact solutions of the governing system. The approaches are practically effective and can be exerted to various types of nonlinear systems of partial differential equations (PDEs). Keywords: SEISLWs, Modified Kudryashov method, Hyperbolic function method, New exact solution
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