78 research outputs found
Thermal non-equilibrium effects in quantum reflection
We show that the quantum reflection coefficient of ultracold heavy atoms
scattering off a dielectric surface can be tuned in a wide range by suitable
choice of surface and environment temperatures. This effect results from a
temperature dependent long-range repulsive part of the van der
Waals-Casimir-Polder-Lifshitz atom-surface interaction potential
Efficient Photoionization-Loading of Trapped Cadmium Ions with Ultrafast Pulses
Atomic cadmium ions are loaded into radiofrequency ion traps by
photoionization of atoms in a cadmium vapor with ultrafast laser pulses. The
photoionization is driven through an intermediate atomic resonance with a
frequency-quadrupled mode-locked Ti:Sapphire laser that produces pulses of
either 100 fsec or 1 psec duration at a central wavelength of 229 nm. The large
bandwidth of the pulses photoionizes all velocity classes of the Cd vapor,
resulting in high loading efficiencies compared to previous ion trap loading
techniques. Measured loading rates are compared with a simple theoretical
model, and we conclude that this technique can potentially ionize every atom
traversing the laser beam within the trapping volume. This may allow the
operation of ion traps with lower levels of background pressures and less trap
electrode surface contamination. The technique and laser system reported here
should be applicable to loading most laser-cooled ion species.Comment: 11 pages, 12 figure
The equilibria that allow bacterial persistence in human hosts
We propose that microbes that have developed persistent relationships with human hosts have evolved cross-signalling mechanisms that permit homeostasis that conforms to Nash equilibria and, more specifically, to evolutionarily stable strategies. This implies that a group of highly diverse organisms has evolved within the changing contexts of variation in effective human population size and lifespan, shaping the equilibria achieved, and creating relationships resembling climax communities. We propose that such ecosystems contain nested communities in which equilibrium at one level contributes to homeostasis at another. The model can aid prediction of equilibrium states in the context of further change: widespread immunodeficiency, changing population densities, or extinctions.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/62883/1/nature06198.pd
Advancing the understanding of treponemal disease in the past and present
Syphilis was perceived to be a new disease in Europe in the late 15th century, igniting a debate about its origin that continues today in anthropological, historical, and medical circles. We move beyond this age-old debate using an interdisciplinary approach that tackles broader questions to advance the understanding of treponemal infection (syphilis, yaws, bejel, and pinta). How did the causative organism(s) and humans co-evolve? How did the related diseases caused by Treponema pallidum emerge in different parts of the world and affect people across both time and space? How are T. pallidum subspecies related to the treponeme causing pinta? The current state of scholarship in specific areas is reviewed with recommendations made to stimulate future work. Understanding treponemal biology, genetic relationships, epidemiology, and clinical manifestations is crucial for vaccine development today and for investigating the distribution of infection in both modern and past populations. Paleopathologists must improve diagnostic criteria and use a standard approach for recording skeletal lesions on archaeological human remains. Adequate contextualization of cultural and environmental conditions is necessary, including site dating and justification for any corrections made for marine or freshwater reservoir effects. Biogeochemical analyses may assess aquatic contributions to diet, physiological changes arising from treponemal disease and its treatments (e.g., mercury), or residential mobility of those affected. Shifting the focus from point of origin to investigating who is affected (e.g., by age/sex or socioeconomic status) and disease distribution (e.g., coastal/ inland, rural/urban) will advance our understanding of the treponemal disease and its impact on people through time
Candida sp in the oral cavity with and without lesions: maximal inhibitory dilution of Propolis and Periogard
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