Angry, Hungry T-Cells: How Are T-Cell Responses Induced in Low Nutrient Conditions?

Upon activation, T-cells increase the uptake of glucose and glutamine to build the constituents of proliferating effectors. However, tumor and infected cells compete for the same nutrients. Several observations are consistently indicating that activated T-cells overcome this situation by engaging catabolic pathways. Here I discuss how these observations are reconciled with T-cells’ need of anabolic processes during activation

Faceted anomalous scaling in the epitaxial growth of semiconductor films

We apply the generic dynamical scaling theory (GDST) to the surfaces of CdTe polycrystalline films grown in glass substrates. The analysed data were obtained with a stylus profiler with an estimated resolution lateral resolution of $l_c=0.3 \mu$m. Both real two-point correlation function and power spectrum analyses were done. We found that the GDST applied to the surface power spectra foresees faceted morphology in contrast with the self-affine surface indicated by the local roughness exponent found via the height-height correlation function. This inconsistency is explained in terms of convolution effects resulting from the finite size of the probe tip used to scan the surfaces. High resolution AFM images corroborates the predictions of GDST.Comment: to appear in Europhysics Letter

Collective Identities and the Integration of Core State Powers: Introduction to the Special Issue

This special issue explores the relationship between collective identities and the integration of core state powers, that is, the delegation of powers to a centralized institution in policy areas that are essential for the functioning of the modern state. In this introductory article we present the main conceptualizations of the contributions to the special issue that define our understanding of collective identities and core state powers. We discuss the multi-level nature of collective identities and we discuss theoretical expectations over the link between collective identities and core state powers. Finally, we briefly present each of the contributions to the issue and discuss how they relate to the broad research goals, the special issue and to each other

Common currency, common identity? The impact of the Euro introduction on European identity

Does European state building go hand in hand with European nation building? This article engages with the scholarly debate on the dynamic relationship between the construction of supranational political institutions that exert key functions of sovereignty and collective identities by investigating the extent to which the adoption of the Euro as a currency is associated with a decrease in the share of Europeans who identify exclusively with their nation and not with the European Union. In detail, by using a dynamic panel-data model on 26 European Union countries in the post-Maastricht period (1996–2017), our results show that the Euro has fostered European identity, leading to a small but significant decrease (-3%) in the share of Europeans with exclusive national identity

Preferences for European unemployment insurance: a question of economic ideology or EU support?

Against the backdrop of proposals to introduce a European unemployment insurance scheme, we study public support for such schemes by conducting a conjoint experiment on support for European unemployment insurance in 13 EU member states. We argue that European-level social policy initiatives and the underlying notions of solidarity cannot be reduced to a one-dimensional concept, but rather include various dimensions. Unemployment schemes vary in their generosity, the conditions for support, their impact on taxation, the extent to which they preclude permanent redistribution between countries, and the EU’s role in their administration. Generosity, conditions and taxation are ‘domestic’ dimensions, since they mainly resonate with domestic policy debates; between-country redistribution and administration are ‘cross-border’ dimensions, referring to relationships between countries. We expect economic ideology to interact predominantly with domestic dimensions and EU support to interact predominantly with cross-border dimensions. Findings confirm these expectations, with the exception of between-country redistribution and country-level conditionality

Collective Identities, European Solidarity: Identification Patterns and Preferences for European Social Insurance

A degree of collective identity is often perceived to be a requirement for integration of core state powers, and even more so when redistributive measures are at stake. Existing research has shown that European identity is an important correlate of support for European social policy in general. This article explores the ways in which collective identities relate to the multidimensional nature of social policy at the European level. We explore in particular the features of European social policy that receive the most support from European publics, and how local, national and European identity moderates these preferences. We expect that people who have primarily sub-national or national attachments are less supportive of generous schemes and schemes that involve greater cross-country redistribution, and are more in favour of decentralized schemes administered by the member states than those with stronger European identities. We find support for these expectations in a conjoint survey experiment fielded in autumn 2018 in 13 EU member states

Refractive elastic scattering of carbon and oxygen nuclei: The mean field analysis and Airy structures

The experimental data on the $^{16}$O$+^{12}$C and $^{18}$O$+^{12}$C elastic scatterings and their optical model analysis are presented. Detailed and complete elastic angular distributions have been measured at the Strasbourg Vivitron accelerator at several energies covering the energy range between 5 and 10 MeV per nucleon. The elastic scattering angular distributions show the usual diffraction pattern and also, at larger angles, refractive effects in the form of nuclear rainbow and associated Airy structures. The optical model analysis unambiguously shows the evolution of the refractive scattering pattern. The observed structure, namely the Airy minima, can be consistently described by a nucleus-nucleus potential with a deep real part and a weakly absorptive imaginary part. The difference in absorption in the two systems is explained by an increased imaginary (mostly surface) part of the potential in the $^{18}$O$+^{12}$C system. The relation between the obtained potentials and those reported for the symmetrical $^{16}$O$+^{16}$O and $^{12}$C$+^{12}$C systems is drawn.Comment: 10 pages, 9 figures, Phys. rev. C in pres

Effect of Hyperbaric Storage at Room Temperature on the Activity of Polyphenoloxidase in Model Systems and Fresh Apple Juice

The effect of hyperbaric storage (HS) on polyphenoloxidase activity (PPO) was studied in model solutions and apple juice. Model solutions containing increasing amounts of mushroom (Agaricus bisporus) PPO (up to 26 U) were stored at room temperature at pressure up to 200 MPa. During HS, samples were assessed for residual PPO activity. The enzyme was completely inactivated according to a first-order kinetic model that was used to calculate PPO decimal reduction time (Dp) and pressure sensitivity (zp = 140.8 MPa) in diluted model solutions (2 U PPO). The increase in enzyme concentration (6–26 U) nullified the effect of HS, probably due to protein structure stabilization by self-crowding. The application of HS at 100 and 200 MPa to apple juice promoted a decrease in total bacteria, lactic acid bacteria, yeasts, and molds. These changes occurred in concomitance with the inactivation of PPO (zp = 227.3 MPa). At 200 MPa, PPO inactivation followed a biphasic first-order kinetic, suggesting the presence of PPO isozymes with different pressure sensitivity. The inactivation of PPO was observed to occur more rapidly with increasing storage pressure and led to the maintenance of the original bright juice color. This study proves the capability of HS to control enzyme-related quality decay in fruit juices and, potentially, in many other food matrices suffering enzymatic alteration