1,408 research outputs found
Negative ion Time Projection Chamber operation with SF at nearly atmospheric pressure
We present measurements of drift velocities and mobilities of some innovative
negative ion gas mixtures at nearly atmospheric pressure based on SF as
electronegative capture agent and of pure SF at various pressures,
performed with the NITEC detector. NITEC is a Time Projection Chamber with 5 cm
drift distance readout by a GEMPix, a triple thin GEMs coupled to a
Quad-Timepix chip, directly sensitive to the deposited charge on each of the 55
55 m pixel. Our results contribute to expanding the knowledge
on the innovative use of SF as negative ion gas and extend to triple thin
GEMs the possibility of negative ion operation for the first time. Above all,
our findings show the feasibility of negative ion operation with
He:CF:SF at 610 Torr, opening extremely interesting possibility for
next generation directional Dark Matter detectors at 1 bar
Experimental results of crystal-assisted slow extraction at the SPS
The possibility of extracting highly energetic particles from the Super
Proton Synchrotron (SPS) by means of silicon bent crystals has been explored
since the 1990's. The channelling effect of a bent crystal can be used to
strongly deflect primary protons and eject them from the synchrotron. Many
studies and experiments have been carried out to investigate crystal
channelling effects. The extraction of 120 and 270 GeV proton beams has already
been demonstrated in the SPS with dedicated experiments located in the ring.
Presently in the SPS, the UA9 experiment is performing studies to evaluate the
possibility to use bent silicon crystals to steer particle beams in high energy
accelerators. Recent studies on the feasibility of extraction from the SPS have
been made using the UA9 infrastructure with a longer-term view of using
crystals to help mitigate slow extraction induced activation of the SPS. In
this paper, the possibility to eject particles into the extraction channel in
LSS2 using the bent crystals already installed in the SPS is presented. Details
of the concept, simulations and measurements carried out with beam are
presented, before the outlook for the future is discussed.Comment: 4 pages, 7 figures, submitted to to International Particle
Accelerator Conference (IPAC) 2017 in Copenhagen, Denmar
Polycapillary optics for soft X-ray imaging and tomography
Magnetic plasmas are extended volumetric sources of X-rays, and these emissions could reveal a lot of information about the processes occurring into the plasmas. Unfortunately, the constraints posed by these toroidal devices (high
neutron flux, gamma and hard-X background, extremely high radiofrequency powers, high magnetic fields, optical limitations and so on) are very severe and limit strongly the possibility to install X-ray detectors directly into or close to the machine. Soft X-ray diagnostics are meant both as tomography and imaging. We started, therefore, to investigate the feasibility of using polycapillary optics for these purposes, in collaboration between Istituto Nazionale di Fisica Nucleare (INFN)- Frascati, Ente per le Nuove tecnologie, l’Energia e l’Ambiente (ENEA)-Frascati and
the Commissariat de l’Energie Atomique (CEA)-Cadarache. The first tests were performed in order to characterize the polycapillary lenses (convergence, divergence, efficiency, spectral dispersion, etc.) for distances much larger than the optical focal length of the lenses, both for the detector and for the source. A silicon-based C-MOS imager (Medipix 2) has been used as a detector and the micro focus X-ray tubes as point-like sources. Results of these preliminary tests are presented, and the imaging capabilities of a polycapillary lens as well
A triple GEM gamma camera for medical application
Abstract A Gamma Camera for medical applications 10 × 10 cm 2 has been built using a triple GEM chamber prototype. The photon converters placed in front of the three GEM foils, has been realized with different technologies. The chamber, High Voltage supplied with a new active divider made in Frascati, is readout through 64 pads, 1 mm 2 wide, organized in a row of 8 cm long, with LHCb ASDQ chip. This Gamma Camera can be used both for X-ray movie and PET-SPECT imaging; this chamber prototype is placed in a scanner system, creating images of 8 × 8 cm 2 . Several measurements have been performed using phantom and radioactive sources of Tc 99 m ( 140 keV ) and Na 22 ( 511 keV ) . Results on spatial resolution and image reconstruction are presented
Nestin expression associates with poor prognosis and triple negative phenotype in locally advanced (T4) breast cancer
Nestin, an intermediate filament protein, has traditionally been noted for its importance as a neural stem cell marker. However, in recent years, expression of nestin has shown to be associated with general proliferation of progenitor cell populations within neoplasms. There is no reported study addressing nestin expression in T4 breast cancer patients. Thus, the aim of the present study was to investigate, through immunohistochemistry, the expression and distribution of nestin in T4 breast cancer, in order to determine its association with clinical and pathological parameters as well as with patients' outcome. Nestin was detectable in tumoral cells and in endothelial cells of blood microvessels, and it is significantly expressed in triple-negative and in inflammatory breast cancer (IBC) subgroups of T4 breast tumours. The Kaplan-Meier analysis showed that the presence of nestin in tumoral cells significantly predicted poor prognosis at 5-years survival (P=0.02) and with borderline significance at 10-years of survival (P=0.05) in T4 breast cancer patients. On the basis of these observations, we speculate that nestin expression may characterize tumours with an aggressive clinical behavior, suggesting that the presence of nestin in tumoral cells and vessels may be considered an important factor that leads to a poor prognosis. Further studies are awaited to define the biological role of nestin in the etiology of these subgroups of breast cancers
- …