118 research outputs found

    Synthesis and preliminary ex vivo evaluation of the spasmolytic activity of 1,3-thiazolium- and 1,3,4-thiadiazolium-5-methylthio- and 5-tioacetate derivatives

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    Seven new compounds have been synthetized in satisfactory yields (51-78 %), through the treatment of mesoionic 1,3-thiazolium-5-thiolate (4a-d) and 1,3,4-thiadiazolium-5-thiolate (10a,b) with chloroacetic acid or methyl iodide: 1,3-thiazolium-5-methylthio- (5a-c), 5-thioacetate (6a,b) and 1,3,4-thiadiazolium-5-methylthio- (11) and 5-thioacetate (12). The structure of the title compounds was elucidated by elemental analysis, IR, 1H and 13C NMR spectroscopy. The newly synthesized compounds 5a, 6a, 11 and 12 were evaluated for their ex vivo spasmolytic potential on four isolated smooth muscles (rat aorta and uterus, guinea pig ileum and trachea) and compared with scopolamine. Some of the compounds exhibited potent spasmolytic activity equal to or stronger than scopolamine

    Seroprevalence for equine infectious anaemia in Equidae seized in the municipality of Petrópolis, State of Rio de Janeiro, Brazil, 2015/2018.

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    Equine infectious anaemia (EIA) is a globally distributed disease caused by a lentivirus. EIA is a notifiable disease that should be reported to the Official Veterinary Service (SVO). Outbreaks are controlled by sacrificing the EIA-positive animals. The study analysed the prevalence of EIA in 165 Equidae seized on public roads in the municipality of Petrópolis, Rio de Janeiro, Brazil, from 2015 to 2018. After the seizure and identification of the Equidae, blood was collected to diagnose EIA. A prevalence of 11.8% was observed among the Equidae seized, and the main risk factor was the region of seizure. A kernel-smoothed map showed areas with the highest density of EIA-positive Equidae in the centre and to the east of the study area. In this region, the chance of seizing an equine positive for EIA was greater (OR=3.6) relative to the remaining region. The implementation and maintenance of Equidae seizures and subsequent diagnostic testing for EIA in the municipality of Petrópolis were shown to have great importance for the control and prevention of the disease. Indicating the place of seizure on the identification cards of the animals enabled delineation of the locations in the municipality of Petrópolis, that had a higher risk of EIApositive animals

    Comunidades quilombolas do Maciço da Pedra Branca preservam o solo da maior floresta urbana do planeta e incrementam seus estoques de carbono do solo.

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    Este Informe Técnico é o resultado de um trabalho conjunto entre Embrapa Solos e AS-PTA por meio do Projeto Sertão Carioca: Conectando Cidade e Floresta, realizado com patrocínio da Petrobras, por meio do Programa Petrobras Socioambiental. Nele, você acessa dados e análises acerca da importância das comunidades quilombolas do Parque Estadual da Pedra Branca, principalmente, no tocante ao incremento dos estoques de carbono no solo. O presente Comunicado Técnico tem o propósito de apresentar resultados das ações de pesquisa conduzidas no Quilombo Cafundá Astrogilda, e assim, difundir uma cultura de sustentabilidade em seus mais diversos aspectos sociais, ambientais, econômicos e culturais, dentro e no entorno de uma unidade de conservação localizada na segunda maior metrópole do país. O serviço ecossistêmico de Sequestro de C do solo da floresta manejada por Quilombolas de Vargem Grande, no Rio de Janeiro, é demonstrado e discutido no âmbito da valorização das pessoas e sua relação com o território para a proteção da floresta, das águas e do clima, vinculado ao conhecimento técnico-científico, vertente de pesquisa do projeto.Informe técnico
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