Hemoglobin genotype has minimal influence on the physiological response of juvenile atlantic cod (Gadus morhua) to environmental challenges

Hemoglobin (Hb) polymorphism in cod is associated with temperature‐related differences in biogeographical distribution, and several authors have suggested that functional characteristics of the various hemoglobin isoforms (HbIs) directly influence phenotypic traits such as growth rate. However, no study has directly examined whether Hb genotype translates into physiological differences at the whole animal level. Thus, we generated a family of juvenile Atlantic cod consisting of all three main Hb genotypes (HbI‐1/1, HbI‐2/2, and HbI‐1/2) by crossing a single pair of heterozygous parents, and we compared their metabolic and cortisol responses to an acute thermal challenge (10&deg;C to their critical thermal maximum [CTM] or 22&deg;C, respectively) and tolerance of graded hypoxia. There were no differences in routine metabolism (at 10&deg;C), maximum metabolic rate, metabolic scope, CTM (overall mean 22.9&deg; &plusmn; 0.2&deg;C), or resting and poststress plasma cortisol levels among Hb genotypes. Further, although the HbI‐1/1 fish grew more (by 15%&ndash;30% during the first 9 mo) when reared at 10&deg; &plusmn; 1&deg;C and had a slightly enhanced hypoxia tolerance at 10&deg;C (e.g., the critical O2 levels for HbI‐1/1, HbI‐2/2, and HbI‐1/2 cod were 35.56% &plusmn; 1.24%, and 40.20% &plusmn; 1.99% air saturation, respectively), these results are contradictory to expectations based on HbI functional properties. Thus, our findings (1) do not support previous assumptions that growth rate differences among cod Hb genotypes result from a more efficient use of the oxygen supply&mdash;that is, reduced standard metabolic rates and/or increased metabolic capacity&mdash;and (2) suggest that in juvenile cod, there is no selective advantage to having a particular Hb genotype with regards to the capacity to withstand ecologically relevant environmental challenges.<br /

Dual Interpretations of Seiberg-Witten and Dijkgraaf-Vafa curves

We give dual interpretations of Seiberg-Witten and Dijkgraaf-Vafa (or matrix model) curves in n=1 supersymmetric U(N) gauge theory. This duality interchanges the rank of the gauge group with the degree of the superpotential; moreover, the constraint of having at most log-normalizable deformations of the geometry is mapped to a constraint in the number of flavors N_f < N in the dual theory.Comment: Latex2e, 22 pages, 2 figure

First observation of two hyperfine transitions in antiprotonic He-3

We report on the first experimental results for microwave spectroscopy of the hyperfine structure of antiprotonic He-3. Due to the helium nuclear spin, antiprotonic He-3 has a more complex hyperfine structure than antiprotonic He-4 which has already been studied before. Thus a comparison between theoretical calculations and the experimental results will provide a more stringent test of the three-body quantum electrodynamics (QED) theory. Two out of four super-super-hyperfine (SSHF) transition lines of the (n,L)=(36,34) state were observed. The measured frequencies of the individual transitions are 11.12559(14) GHz and 11.15839(18) GHz, less than 1 MHz higher than the current theoretical values, but still within their estimated errors. Although the experimental uncertainty for the difference of these frequencies is still very large as compared to that of theory, its measured value agrees with theoretical calculations. This difference is crucial to be determined because it is proportional to the magnetic moment of the antiproton.Comment: 8 pages, 6 figures, just published (online so far) in Physics Letters

Formation of mammalian erythrocytes: chromatin condensation and enucleation

In all vertebrates, the cell nucleus becomes highly condensed and transcriptionally inactive during the final stages of red cell biogenesis. Enucleation, the process by which the nucleus is extruded by budding off from the erythroblast, is unique to mammals. Enucleation has critical physiological and evolutionary significance in that it allows an elevation of hemoglobin levels in the blood and also gives red cells their flexible biconcave shape. Recent experiments reveal that enucleation involves multiple molecular and cellular pathways that include histone deacetylation, actin polymerization, cytokinesis, cell–matrix interactions, specific microRNAs and vesicle trafficking; many evolutionarily conserved proteins and genes have been recruited to participate in this uniquely mammalian process. In this review, we discuss recent advances in mammalian erythroblast chromatin condensation and enucleation, and conclude with our perspectives on future studies.National Institutes of Health (U.S.) (Grant P01 HL 32262)Amgen Inc. (Research Grant

Quiver Theories from D6-branes via Mirror Symmetry

We study N=1 four dimensional quiver theories arising on the worldvolume of D3-branes at del Pezzo singularities of Calabi-Yau threefolds. We argue that under local mirror symmetry D3-branes become D6-branes wrapped on a three torus in the mirror manifold. The type IIB (p,q) 5-brane web description of the local del Pezzo, being closely related to the geometry of its mirror manifold, encodes the geometry of 3-cycles and is used to obtain gauge groups, quiver diagrams and the charges of the fractional branes.Comment: 30 pages, citations adde

Worldsheet Matter Superfields on Half-Shell

In this paper we discuss some of the effects of using "unidexterous" worldsheet superfields, which satisfy worldsheet differential constraints and so are partly on-shell, i.e., on half-shell. Most notably, this results in a stratification of the field space that reminds of "brane-world" geometries. Linear dependence on such superfields provides a worldsheet generalization of the super-Zeeman effect. In turn, non-linear dependence yields additional left-right asymmetric dynamical constraints on the propagating fields, again in a stratified fashion.Comment: 15 pages, 2 figures; minor algebraic correction

On ADE Quiver Models and F-Theory Compactification

Based on mirror symmetry, we discuss geometric engineering of N=1 ADE quiver models from F-theory compactifications on elliptic K3 surfaces fibered over certain four-dimensional base spaces. The latter are constructed as intersecting 4-cycles according to ADE Dynkin diagrams, thereby mimicking the construction of Calabi-Yau threefolds used in geometric engineering in type II superstring theory. Matter is incorporated by considering D7-branes wrapping these 4-cycles. Using a geometric procedure referred to as folding, we discuss how the corresponding physics can be converted into a scenario with D5-branes wrapping 2-cycles of ALE spaces.Comment: 21 pages, Latex, minor change

Elaborations on the String Dual to N=1 SQCD

In this paper we make further refinements to the duality proposed between N=1 SQCD and certain string (supergravity plus branes) backgrounds, working in the regime of comparable large number of colors and flavors. Using the string theory solutions, we predict different field theory observables and phenomena like Seiberg duality, gauge coupling and its running, the behavior of Wilson and 't Hooft loops, anomalous dimensions of the quark superfields, quartic superpotential coupling and its running, continuous and discrete anomaly matching. We also give evidence for the smooth interpolation between higgsed and confining vacua. We provide several matchings between field theory and string theory computations.Comment: 44 pages, 6 figures. References added, minor rewritings, published versio

Heat transport and phonon localization in mass-disordered harmonic crystals

We investigate the steady state heat current in two and three dimensional disordered harmonic crystals in a slab geometry, connected at the boundaries to stochastic white noise heat baths at different temperatures.The disorder causes short wavelength phonon modes to be localized so the heat current in this system is carried by the extended phonon modes which can be either diffusive or ballistic. Using ideas both from localization theory and from kinetic theory we estimate the contribution of various modes to the heat current and from this we obtain the asymptotic system size dependence of the current. These estimates are compared with results obtained from a numerical evaluation of an exact formula for the current, given in terms of a frequency transmission function, as well as from direct nonequilibrium simulations. These yield a strong dependence of the heat flux on boundary conditions. Our analytical arguments show that for realistic boundary conditions the conductivity is finite in three dimensions but we are not able to verify this numerically, except in the case where the system is subjected to an external pinning potential. This case is closely related to the problem of localization of electrons in a random potential and here we numerically verify that the pinned three dimensional system satisfies Fourier's law while the two dimensional system is a heat insulator. We also investigate the inverse participation ratio of different normal modes.Comment: 30 pages, 28 figures (Revised and improved version