The Intracellular Localization of Hormonal Activity in Transplantable Thyrotropin-Secreting Pituitary Tumors in Mice

Mouse pituitary tumors secreting almost exclusively thyroid stimulating hormone have been characterized electron microscopically. Tumors of known thyrotropin content were separated into nuclear, mitochondrial, microsomal, and soluble fractions by differential centrifugation. The hormonal activity of these fractions was correlated with that of the total homogenates and with their nitrogen and phosphorus content. Essentially all the thyrotropin of the homogenate was recovered in a particulate fraction sedimenting between 20,000 and 40,000 g. This fraction contained the RNA granules and membranous components typical of microsomal pellets, but also showed the presence of small dense bodies surrounded by smooth membranes. These bodies were also visible within the endoplasmic reticulum of intact cells, and it is postulated that these bodies may represent the sites of intracellular elaboration and/or storage of TSH. Thyrotropin is tightly associated with microsomal particles but can be brought into solution by treatment with alkaline media, deoxycholate, and certain organic solvents

Non-linear Simulations of MHD Instabilities in Tokamaks Including Eddy Current Effects and Perspectives for the Extension to Halo Currents

The dynamics of large scale plasma instabilities can strongly be influenced by the mutual interaction with currents flowing in conducting vessel structures. Especially eddy currents caused by time-varying magnetic perturbations and halo currents flowing directly from the plasma into the walls are important. The relevance of a resistive wall model is directly evident for Resistive Wall Modes (RWMs) or Vertical Displacement Events (VDEs). However, also the linear and non-linear properties of most other large-scale instabilities may be influenced significantly by the interaction with currents in conducting structures near the plasma. The understanding of halo currents arising during disruptions and VDEs, which are a serious concern for ITER as they may lead to strong asymmetric forces on vessel structures, could also benefit strongly from these non-linear modeling capabilities. Modeling the plasma dynamics and its interaction with wall currents requires solving the magneto-hydrodynamic (MHD) equations in realistic toroidal X-point geometry consistently coupled with a model for the vacuum region and the resistive conducting structures. With this in mind, the non-linear finite element MHD code JOREK has been coupled with the resistive wall code STARWALL, which allows to include the effects of eddy currents in 3D conducting structures in non-linear MHD simulations. This article summarizes the capabilities of the coupled JOREK-STARWALL system and presents benchmark results as well as first applications to non-linear simulations of RWMs, VDEs, disruptions triggered by massive gas injection, and Quiescent H-Mode. As an outlook, the perspectives for extending the model to halo currents are described.Comment: Proceeding paper for Theory of Fusion Plasmas (Joint Varenna-Lausanne International Workshop), Varenna, Italy (September 1-5, 2014); accepted for publication in: to Journal of Physics: Conference Serie

Beam-Ion Acceleration during Edge Localized Modes in the ASDEX Upgrade Tokamak

The acceleration of beam ions during edge localized modes (ELMs) in a tokamak is observed for the first time through direct measurements of fast-ion losses in low collisionality plasmas. The accelerated beamion population exhibits well-localized velocity-space structures which are revealed by means of tomographic inversion of the measurement, showing energy gains of the order of tens of keV. This suggests that the ion acceleration results from a resonant interaction between the beam ions and parallel electric fields arising during the ELM. Orbit simulations are carried out to identify the mode-particle resonances responsible for the energy gain in the particle phase space. The observation motivates the incorporation of a kinetic description of fast particles in ELM models and may contribute to a better understanding of the mechanisms responsible for particle acceleration, ubiquitous in astrophysical and space plasmas.H2020 Marie- Sklodowska Curie programme (Grant No. 708257)Ministerio de Economía y Competitividad. FIS2015-69362-

3D simulations of vertical displacement events in tokamaks: A benchmark of M3D-C1^1, NIMROD and JOREK

In recent years, the nonlinear 3D magnetohydrodynamic codes JOREK, M3D-C$^1$ and NIMROD developed the capability of modelling realistic 3D vertical displacement events (VDEs) including resistive walls. In this paper, a comprehensive 3D VDE benchmark is presented between these state of the art codes. The simulated case is based on an experimental NSTX plasma but with a simplified rectangular wall. In spite of pronounced differences between physics models and numerical methods, the comparison shows very good agreement in the relevant quantities used to characterize disruptions such as the 3D wall forces and energy decay. This benchmark does not only bring confidence regarding the use of the mentioned codes for disruption studies, but also shows differences with respect to the used models (e.g. reduced versus full MHD models). The simulations show important 3D features for a NSTX plasma such as the self-consistent evolution of the halo current and the origin of the wall forces. In contrast to other reduced MHD models based on an ordering in the aspect ratio, the ansatz based JOREK reduced MHD model allows capturing the 3D dynamics even in the spherical tokamak limit considered here