Simulation Studies of Delta-ray Backgrounds in a Compton-Scatter Transition Radiation Detector

In order to evaluate the response to cosmic-ray nuclei of a Compton-Scatter Transition Radiation Detector in the proposed ACCESS space-based mission, a hybrid Monte Carlo simulation using GEANT3 and an external transition radiation (TR) generator routine was constructed. This simulation was employed to study the effects of delta-ray production induced by high-energy nuclei and to maximize the ratio of TR to delta-ray background. The results demonstrate the ability of a Compton-Scatter Transition Radiation Detector to measure nuclei from boron to iron up to Lorentz factors ~ 10^5 taking into account the steeply falling power-law cosmic ray spectra.Comment: Presented at TRDs for the 3rd millennium: Third Workshop on advanced Transition Radiation Detectors for accelerator and space applications, Ostuni, Italy, September 2005, 4 pages, 2 figure

The Conditions of Discretion: Autonomy, Community, Bureaucracy

A Review of The Conditions of Discretion: Autonomy, Community, Bureaucracy/em by Joel F. Handle

On the Direct Detection of Dark Matter Annihilation

We investigate the direct detection phenomenology of a class of dark matter (DM) models in which DM does not directly interact with nuclei, {but rather} the products of its annihilation do. When these annihilation products are very light compared to the DM mass, the scattering in direct detection experiments is controlled by relativistic kinematics. This results in a distinctive recoil spectrum, a non-standard and or even absent annual modulation, and the ability to probe DM masses as low as a $\sim$10 MeV. We use current LUX data to show that experimental sensitivity to thermal relic annihilation cross sections has already been reached in a class of models. Moreover, the compatibility of dark matter direct detection experiments can be compared directly in $E_{{\rm min}}$ space without making assumptions about DM astrophysics, mass, or scattering form factors. Lastly, when DM has direct couplings to nuclei, the limit from annihilation to relativistic particles in the Sun can be stronger than that of conventional non-relativistic direct detection by more than three orders of magnitude for masses in a 2-7 GeV window.Comment: 4 pages, 3 figures, PRL versio

Halo Independent Direct Detection of Momentum-Dependent Dark Matter

We show that the momentum dependence of dark matter interactions with nuclei can be probed in direct detection experiments without knowledge of the dark matter velocity distribution. This is one of the few properties of DM microphysics that can be determined with direct detection alone, given a signal of dark matter in multiple direct detection experiments with different targets. Long-range interactions arising from the exchange of a light mediator are one example of momentum-dependent DM. For data produced from the exchange of a massless mediator we find for example that the mediator mass can be constrained to be $\lesssim 10$ MeV for DM in the 20-1000 GeV range in a halo-independent manner.Comment: 15 pages, 4 figures; updated to match published versio

Interim report on the hydrologic features of the Green Swamp area in Central Florida

The Green Swamp area in central Florida is another area where man is developing agricultural land from marginal land. Though the area is by no means as extensive as that of the Everglades, the present efforts for its development are similar to the early efforts for developing the Everglades in that many miles of canals and ditches have been constructed to improve the drainage. Lest the early mistakes of the Everglades be repeated, the Florida Department of Water Resources considered that an appraisal of the physical and hydrologic features of the area was needed to determine the broad effects of draining and developing the swamp. This reconnaissance provides information required by the State of Florida for determining its responsibility and policy in regard to the Green Swamp area and for formulating future plans for water management of the area. Some of the features that have been determined are: the amount of rainfall on the area; the pattern of surfacewater drainage; the amount and direction of surface-water runoff; the direction of ground-water movement; the interrelationship of rainfall, surface water, and ground water; the effects of improved drainage facilities'; and the effects of the hydrologic environment on the chemical quality of water of the area.(PDF contains 106 pages.

Neutrino scattering and flavor transformation in supernovae

We argue that the small fraction of neutrinos that undergo direction-changing scattering outside of the neutrinosphere could have significant influence on neutrino flavor transformation in core-collapse supernova environments. We show that the standard treatment for collective neutrino flavor transformation is adequate at late times, but could be inadequate in the crucial shock revival/explosion epoch of core-collapse supernovae, where the potentials that govern neutrino flavor evolution are affected by the scattered neutrinos. Taking account of this effect, and the way it couples to entropy and composition, will require a new paradigm in supernova modeling.Comment: 5 pages, 3 figure

Halo Modification of a Supernova Neutronization Neutrino Burst

We give the first self-consistent calculation of the effect of the scattered neutrino halo on flavor evolution in supernovae. Our example case is an O-Ne-Mg core collapse supernova neutronization neutrino burst. We find that the addition of the halo neutrinos produces qualitative and quantitative changes in the final flavor states of neutrinos. We also find that the halo neutrinos produce a novel distortion of the neutrino flavor swap. Our results provide strong motivation for tackling the full multidimensional and composition-dependent aspects of this problem in the future.Comment: 14 pages, 13 figures, 1 tabl

Radiolabeling human peripheral blood stem cells for positron emission tomography (PET) imaging in young rhesus monkeys.

These studies focused on a new radiolabeling technique with copper ((64)Cu) and zirconium ((89)Zr) for positron emission tomography (PET) imaging using a CD45 antibody. Synthesis of (64)Cu-CD45 and (89)Zr-CD45 immunoconjugates was performed and the evaluation of the potential toxicity of radiolabeling human peripheral blood stem cells (hPBSC) was assessed in vitro (viability, population doubling times, colony forming units). hPBSC viability was maintained as the dose of (64)Cu-TETA-CD45 increased from 0 (92%) to 160 µCi/mL (76%, p>0.05). Radiolabeling efficiency was not significantly increased with concentrations of (64)Cu-TETA-CD45 >20 µCi/mL (p>0.50). Toxicity affecting both growth and colony formation was observed with hPBSC radiolabeled with ≥40 µCi/mL (p<0.05). For (89)Zr, there were no significant differences in viability (p>0.05), and a trend towards increased radiolabeling efficiency was noted as the dose of (89)Zr-Df-CD45 increased, with a greater level of radiolabeling with 160 µCi/mL compared to 0-40 µCi/mL (p<0.05). A greater than 2,000 fold-increase in the level of (89)Zr-Df-CD45 labeling efficiency was observed when compared to (64)Cu-TETA-CD45. Similar to (64)Cu-TETA-CD45, toxicity was noted when hPBSC were radiolabeled with ≥40 µCi/mL (p<0.05) (growth, colony formation). Taken together, 20 µCi/mL resulted in the highest level of radiolabeling efficiency without altering cell function. Young rhesus monkeys that had been transplanted prenatally with 25×10(6) hPBSC expressing firefly luciferase were assessed with bioluminescence imaging (BLI), then 0.3 mCi of (89)Zr-Df-CD45, which showed the best radiolabeling efficiency, was injected intravenously for PET imaging. Results suggest that (89)Zr-Df-CD45 was able to identify engrafted hPBSC in the same locations identified by BLI, although the background was high