14 research outputs found
Pengembangan Alat Gerak Jatuh Bebas Sebagai Media Pembelajaran Konsep Gerak Jatuh Bebas
This research development aimed to produce a Free Fall Motion device and LKS that can be used as an media of physics learning.The model was adapted from Sadiman which included phases need analysis, formulate learning objective, materials, develop evaluation instruments, prepare draft of media, validation from expert, experiments, and final product. Results of this study produced the Free Fall Motion device which able to measure the time of falling object automatically, vary the height of falling objects, release the falling objects automatically, and investigate influence of mass toward the time of falling object use sound sensor.The product which was developed had been tested expertly testing design and materials. Results from experiments showed that device used very attractive, easy to use, and very useful. The learning outcomes of students after using the device showed that 100% had reached KKM so that the developed product was highly effective and acceptable to be used as a learning media.Penelitian ini bertujuan menghasilkan alat Gerak Jatuh Bebas beserta LKS yang dapat digunakan sebagai media pembelajaran fisika. Model pengembangan diadaptasi dari Sadiman yang meliputi tahapan analisis kebutuhan, merumuskan tujuan pembelajaran, butir-butir materi, menyusun instrumen evaluasi, menyusun draft media, validasi ahli, uji coba, dan produk akhir. Hasil penelitian berupa alat Gerak Jatuh Bebas yang mampu mengukur waktu jatuh benda secara otomatis, memvariasikan ketinggian jatuh benda, pelepasan benda jatuh secara otomatis, dan dapat menyelidiki pengaruh massa benda terhadap waktu jatuh dengan memanfaatkan sensor suara. Produk yang dikembangkan telah diuji desain dan materi. Hasil uji coba menyatakan bahwa alat yang digunakan sangat menarik, mudah digunakan, dan sangat bermanfaat. Hasil belajar siswa setelah menggunakan alat ini 100% mencapai batas KKM sehingga produk yang dikembangkan sangat efektif dan layak digunakan sebagai media pembelajaran
Pengembangan Multimedia Interaktif Tutorial Menggunakan Pendekatan Kontekstual
The results of needed analysis is known that Learning activities of students generally rely on print books as instructional media. It make the students feel bored and less interested and also feel difficult on physics subject. Consider the problem, researchers developed an multimedia interactive tutorial using a contextual approached that feasible and effective. Development procedures include: analyzing of needed, formulating learning goals, formulating the item of subject, formulating successfull measurement, drafting, validating, testing and revising, and also the final product. Products have been developed tested by the experts and tested on students. Experimental results show that the products used are very attractive, very easy to use, and very useful. The results of learning students stated that the multimedia interactive tutorial that have been developed is effective and feasible to be used as a instructional media.Hasil analisis kebutuhan diketahui bahwa Kegiatan belajar siswa umumnya hanya mengandalkan buku cetak sebagai media pembelajaran. Hal tersebut membuat siswa merasa bosan dan kurang tertarik serta mengalami kesulitan terhadap pelajaran fisika. Mempertimbangkan masalah tersebut, peneliti mengembangkan multimedia interaktif tutorial dengan menggunakan pendekatan kontekstual yang layak dan efektif. Prosedur pengembangan meliputi: analisis kebutuhan, merumuskan tujuan pembelajaran, merumuskan butir-butir materi, Perumusan alat ukur keberhasilan, menyusun naskah, melakukan validasi, melakukan uji coba dan revisi, dan produk akhir. Produk yang dikembangkan telah diuji oleh ahli dan diujicobakan pada siswa. Hasil uji coba menunjukkan bahwa produk yang digunakan sangat menarik, sangat mudah digunakan, dan sangat bermanfaat. Hasil belajar siswa menyatakan bahwa multimedia interaktif tutorial yang dikembangkan efektif dan layak digunakan sebagai media pembelajaran
Pemanfaatan Media Tik Tutorial Sebagai Komplemen Demonstrasi Pada Pembelajaran Alat Ukur Di SMP
The purposes of this study were to determine the increasing of cognitive learning outcomes of students and to describe the Science Process Skills (sps), the character, the activities, and students attitudes toward the use of ICT tutorial media as a demonstration complement on the learning of measurement tools. This research was conducted at the first semester of the academic year 2013/2014 at the Junior High School 1 Seputih Agung, Central Lampung and the design of this research was One-Shot Case Study. The results of this research showed that there is an increasing in cognitive learning outcomes of students, it can build the KPS of students, it can build the character of the students, it can increase the activities of the students, and it can increase a positive attitudes of the students.Penelitian ini bertujuan untuk: mengetahui peningkatan hasil belajar ranah kognitif, mendeskripsikan KPS, karakter, aktivitas dan sikap siswa terhadap pemanfaatan media TIK tutorial sebagai komplemen demonstrasi pada pembelajaran alat ukur. Penelitian ini dilakukan di semester ganjil pada tahun ajaran 2013/2014 di SMP Negeri 1 Seputih Agung, Lampung Tengah dan desain penelitian yang digunakan adalah One-Shot Case Study. Hasil penelitian ini adalah terdapat peningkatan hasil belajar ranah kognitif siswa, dapat membangun KPS siswa, dapat menumbuhkan karakter siswa, dapat meningkatkan aktivitas belajar siswa dan membangun sikap positif siswa
Studi Perbandingan Hasil Belajar Fisika Antara Penggunaan Gambar Bergerak Dengan Gambar Statis
The purposes of this research were to determine the difference of learning outcome used dynamic images with static images and describe each of learning outcome. The samples in this research were students of class X in SMA Negeri 3 Kotabumi. The research was conducted used the one-group pretest-posttest design. Data were tested with N-gain analysis, normality test, homogeneity test and Mann-Whitney test. The results of Mann-Whitney test, asymp.sig value was 0.014, it can be stated that the average N-gain of learning outcomes used dynamic image is higher than the average N-gain of learning outcome of static image. Based on these result, there was the difference in learning outcome between two experimental classes. Beside that, there was an increasing of student's learning outcome by medium category which used dynamic image as well as static image.Tujuan penelitian ini adalah untuk mengetahui perbedaan hasil belajar berbantuan gambar bergerak dengan gambar statis dan mendiskripsikan masing-masing hasil belajar. Sampel penelitian ini adalah siswa kelas X SMA Negeri 3 Kotabumi. Penelitian dilakukan menggunakan one-group pretest-posttest design. Data diuji dengan analisis N-gain, uji normalitas, uji homogenitas dan uji Mann-Whitney. Hasil dari uji Mann-Whitney, nilai asymp. sig. yaitu 0,014, maka dapat dinyatakan rata-rata N-gain hasil belajar berbantuan gambar bergerak lebih tinggi dibandingkan dengan rata-rata N-gain hasil belajar berbantuan gambar statis. Sehingga dapat dikatakan, terdapat perbedaan hasil belajar antara kedua kelas eksperimen. Seain itu, hasil belajar siswa berbantuan gambar bergerak, maupun gambar statis mengalami peningkatan dengan kategori sedang
Pengembangan Multimedia Interaktif Model Tutorial
This developmental research was intended to make an interactiveΓ multimedia tutorial model by using Microsoft PowerPoint for SMP/MTs on theΓ static and dynamic electricity subjects that contain materials, interactiveΓ animation, virtual labs, exercises, and competence test. This design ofΓ evelopmental research modified the process of the instructional mediaΓ development developed by Sadiman, et al. With the stages of work procedureΓ that comprise needs analysis, objectives, materials, synopsis, initial script,Γ prototype production, evaluation consisting of three phases, namely the materialΓ expert test, the design expert test, and one on one expert test. This also includesΓ revision, final script, trials, and final program. The result of one on one testΓ stating that this interactive multimedia has an interesting quality, easy to use,and it is very useful. It is also the same with the result of field test that also hasΓ an interesting quality, easy to use, and it is very useful also.From the result of theΓ field test can be concluded that this interactive multimedia is very effective to beused as a learning resource.
Perbandingan Aktivitas Dan Hasil Belajar Menggunakan Penilaian Otentik Dengan Penilaian Konvensional
Learning activity is a series of physical and mental activity. To obtain a good learning result the physical and mental activity must be coordinated. The better the activities undertaken by the students then students will understand and master the subject matter presented by the teacher, so that students will gain maximum learning results. The aim of this study was to determine the activity and higher student outcomes between classes using authentic assessment models with conventional assessment models. The population in this study were high school students of class VII in Utama 2 Bandar Lampung while the sample is class X1 and X4 semester Utama 2 Bandar Lampung school, sampling was take using Purposive Sampling technique. Variable was consist of two independent variables and two dependent variables, Authentic Assessment, Conventional Assessment, Activity, and Learning Outcomes. Different test using Independent Sample t-Test showed H0 is rejected. The results showed that learning activities for classroom use authentic assessment is higher than the class that uses conventional assessment, while learning outcomes did not show any difference.Aktivitas belajar adalah serangkaian kegiatan fisik dan mental. Untuk memperoleh hasil belajar yang baik maka aktivitas fisik dan mental harus terkoordinasi dengan baik. Semakin baik aktivitas yang dilakukan oleh siswa maka siswa akan semakin memahami dan meguasai materi pelajaran yang disampaikan oleh guru, sehingga siswa akan memperoleh hasil belajar yang maksimal. Penelitian ini bertujuan untuk mengetahui Aktivitas dan hasil siswa yang lebih tinggi antara kelas yang menggunakan model penilaian otentik dengan model penilaian konvensional. Populasi pada penelitian ini adalah siswa kelas VII di SMA Utama 2 Bandar Lampung sedangkan sampelnya adalah siswa kelas X1 dan X4 semester ganjil SMA Utama 2 Bandar Lampung, pengambilan sampel dilakukan dengan teknik Purposive Sampling. Variabel terdiri dari dua variabel bebas dan dua variabel terikat. Uji beda menggunakan uji Independent Sample t-Test menunjukkan H0 ditolak. Hasil penelitian memperlihatkan aktivitas belajar untuk kelas yang menggunakan penilaian otentik lebih tinggi dari kelas yang menggunakan penilaian konvensional, sedangkan hasil belajar tidak menunjukkan adanya perbedaan
Perbandingan Kps Dan Hasil Belajar Menggunakan Metode Eksperimen Laboratorium Nyata Dan Maya
Experiments need to be conducted in order to develop scientific thinking in a systematic, objective, critical and rational and training Science Process Skills (SPS) students but the experimental method is rarely done in schools due to lack of lab equipment in the lab. The purpose of this research was to determine differences in SPS and student learning achievement caused by the use of experimental methods and to investigate the interaction between the use of experimental methods and the prior knowledge when viewed from the acquisition of SPS score and the learning achievement of student. The research design was factorial design and hypothesis testing using univariate tests. Mean of student SPS scores who experiment in virtual laboratory was 18.6 and 71.4 for their learning achievement. KPS score who experiment in real laboratory was 17.7 and 60.2 for their learning achievement. Univariate test results showed no effect of the experimental method to the SPS and t learning achievement of students. Obtained a significant interaction between the experimental method and prior knowledge when viewed from KPS score and learning achievement
The Improving of Methylprednisolone Palmitate Potency After Incorporated with Liposome - an Antiinflammation Study in Culture of Mice\u27s Splenocytes
Glucocorticoid has been used as an antiinflammatory and immuno-suppresive drug. Longterm utilisation at high dose of glucocorticoid is associated with serious side effects. In recent years, many attempts have been performed in searching the appropiate vehicles to deliver the drug directly into the target organ or the receptor. By incorporating the drug into its vehicle such as liposome, the systemic side effect can be minimized. Purwaningsih et al has successfully synthetized a novel preparation of liposome methylprednisolone palmitate (L-MPLP). The aim of the study was to learn the pharmacological effect of L-MPLP, especially on antiinflammatory effect of this novel preparation, compared with the standard methylprednisolone (MPL). The parameter was the potency of L-MPLP in reducing gamma-interferon production in T-lymphocyte culture after stimulation with concanavalin A in vitro as well as in vivo. Gamma-interferon was assayed by ELISA method. The reduction of gamma interferon, in vivo, after the administration of L-MPLP at the dose of 2,8 and 16 mg/kgBW respectively, showed significant difference than a control group, while MPL did not. The addition of both L-MPLP and MPL in in vitro culture at the concentration of 5.10-3, 5.10-2 and 5.10-1 mM have proved to suppress the gammainterferon production, where the suppression of L-MPLP was more effective than MPL, significantly
ΠΡΡΠΊΡΠΌΠΈΠ½ ΡΠ½ΠΈΠΆΠ°Π΅Ρ ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΡΠ°ΠΊΠ° ΠΌΠΎΠ»ΠΎΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ ΡΠ΅ΡΠ΅Π· Π±Π΅Π»ΠΊΠΈ RASSF1A, Bax ΠΈ caspase-3
Background. Curcumin is a polyphenol that has pharmacological activity that can inhibit tumor cell growth and induce apoptosis through various mechanisms. However, the specifc mechanism of curcumin cytotoxicity remains controversial because of many anti- and pro-apoptotic signaling pathways in various cell types.This study aims to examine the relationship among curcumin on RASSF1A, Bax protein levels, and caspase-3 activity in supporting the apoptotic mechanism in CSA03 breast cancer cells.Material and Methods. Curcumin administration to cancer cells is based on differences in dosage with 24-hour incubation. Cytotoxicity after curcumin administration was determined using MTS. RASSF1A and Bax protein levels were tested through ELISA. Caspase-3 activity was used to determine apoptosis and was tested using fow cytometry.Results. The results indicated that curcumin had a cytotoxicity effect of 40.85 Β΅g/mL. At concentrations of 40 Β΅g/mL and 50 Β΅g/mL, curcumin increases levels of protein RASSF1A (β = 26.53% and 47.35%, respectively), Bax (β = 48.79% and 386.15%), and caspase-3 (β = 1,678.51% and 1,871.889%) signifcantly.Conclusions. Curcumin exhibits anti-proliferative activity and apoptotic (Caspase-3) effects through activation of RASSF1A and Bax.Β ΠΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ. ΠΡΡΠΊΡΠΌΠΈΠ½ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΠ΅Ρ ΡΠΎΠ±ΠΎΠΉ ΠΏΠΎΠ»ΠΈΡΠ΅Π½ΠΎΠ», ΠΎΠ±Π»Π°Π΄Π°ΡΡΠΈΠΉ ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ, ΠΊΠΎΡΠΎΡΠ°Ρ ΠΌΠΎΠΆΠ΅Ρ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΠ²Π°ΡΡ ΡΠΎΡΡ ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ ΠΈ Π²ΡΠ·ΡΠ²Π°ΡΡ Π°ΠΏΠΎΠΏΡΠΎΠ· Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠΎΠ². ΠΠ΄Π½Π°ΠΊΠΎ ΠΊΠΎΠ½ΠΊΡΠ΅ΡΠ½ΡΠΉ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌ ΡΠΈΡΠΎΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΠΈ ΠΊΡΡΠΊΡΠΌΠΈΠ½Π° ΠΎΡΡΠ°Π΅ΡΡΡ ΡΠΏΠΎΡΠ½ΡΠΌ ΠΈΠ·-Π·Π° ΠΌΠ½ΠΎΠΆΠ΅ΡΡΠ²Π° Π°Π½ΡΠΈ- ΠΈ ΠΏΡΠΎΠ°ΠΏΠΎΠΏΡΠΎΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΈΠ³Π½Π°Π»ΡΠ½ΡΡ
ΠΏΡΡΠ΅ΠΉ Π² ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΡΠΈΠΏΠ°Ρ
ΠΊΠ»Π΅ΡΠΎΠΊ.Π¦Π΅Π»ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ²ΠΈΠ»ΠΎΡΡ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·ΠΈ ΠΊΡΡΠΊΡΠΌΠΈΠ½Π° Ρ ΡΡΠΎΠ²Π½ΡΠΌΠΈ Π±Π΅Π»ΠΊΠ° RASSF1A, Bax ΠΈ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ ΠΊΠ°ΡΠΏΠ°Π·Ρ-3 Π² ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠΊΠ΅ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠ° Π°ΠΏΠΎΠΏΡΠΎΠ·Π° Π² ΠΊΠ»Π΅ΡΠΊΠ°Ρ
ΡΠ°ΠΊΠ° ΠΌΠΎΠ»ΠΎΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ CSA03.ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΊΡΡΠΊΡΠΌΠΈΠ½Π° Π² ΡΠ°ΠΊΠΎΠ²ΡΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΎ Π½Π° ΡΠ°Π·Π»ΠΈΡΠΈΡΡ
Π² Π΄ΠΎΠ·ΠΈΡΠΎΠ²ΠΊΠ΅ ΠΏΡΠΈ 24-ΡΠ°ΡΠΎΠ²ΠΎΠΉ ΠΈΠ½ΠΊΡΠ±Π°ΡΠΈΠΈ. Π¦ΠΈΡΠΎΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΡ ΠΏΠΎΡΠ»Π΅ Π²Π²Π΅Π΄Π΅Π½ΠΈΡ ΠΊΡΡΠΊΡΠΌΠΈΠ½Π° ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΠΈ Ρ ΠΏΠΎΠΌΠΎΡΡΡ MTS. Π£ΡΠΎΠ²Π½ΠΈ Π±Π΅Π»ΠΊΠΎΠ² RASSF1A ΠΈ Bax ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π»ΠΈ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ELISA. ΠΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΊΠ°ΡΠΏΠ°Π·Ρ-3 ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»ΠΈ Π΄Π»Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ Π°ΠΏΠΎΠΏΡΠΎΠ·Π° ΠΈ ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π»ΠΈ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΏΡΠΎΡΠΎΡΠ½ΠΎΠΉ ΡΠΈΡΠΎΠΌΠ΅ΡΡΠΈΠΈ. Π‘ΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΎΠ±ΡΠ°Π±ΠΎΡΠΊΠ° Π΄Π°Π½Π½ΡΡ
ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»Π°ΡΡ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΡ Statistical Program for Social Science (SPSS) Π²Π΅ΡΡΠΈΠΈ 20.0 Π΄Π»Ρ Windows. ΠΡΠΎΠ²Π΅ΡΠΊΠ° Π³ΠΈΠΏΠΎΡΠ΅Π· Π²ΡΠΏΠΎΠ»Π½ΡΠ»Π°ΡΡ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π½Π΅ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΈΡΠ»Π΅Π½Π½ΠΎΠ³ΠΎ ΡΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ΅ΡΡΠ° ΠΏΡΠΎΠ²Π΅ΡΠΊΠΈ Π³ΠΈΠΏΠΎΡΠ΅Π·. ΠΠ»Ρ ΠΎΡΠ΅Π½ΠΊΠΈ ΡΠ°Π·Π½ΠΈΡΡ ΠΌΠ΅ΠΆΠ΄Ρ >2 Π³ΡΡΠΏΠΏΠ°ΠΌΠΈ Π½Π΅ΠΏΠ°ΡΠ½ΡΡ
ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΉ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»ΠΈ Π½Π΅ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΊΡΠΈΡΠ΅ΡΠΈΠΉ ΠΡΡΡΠΊΠ°Π»Π°βΠ£ΠΎΠ»Π»ΠΈΡΠ°, Π° Π΄Π»Ρ ΠΎΡΠ΅Π½ΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΠΎΠΉ ΡΠ°Π·Π½ΠΈΡΡ Π² Π΄Π²ΡΡ
Π³ΡΡΠΏΠΏΠ°Ρ
ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Π°ΠΏΠΎΡΡΠ΅ΡΠΈΠΎΡΠ½ΡΠΉ Π°Π½Π°Π»ΠΈΠ· ΠΠ°Π½Π½Π°βΠ£ΠΈΡΠ½ΠΈ.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΡΠΈΡΠΎΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΡΡΠ΅ΠΊΡ ΠΊΡΡΠΊΡΠΌΠΈΠ½Π° ΡΠΎΡΡΠ°Π²ΠΈΠ» 40,85 ΠΌΠΊΠ³/ΠΌΠ». Π ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΡΡ
40 ΠΌΠΊΠ³/ΠΌΠ» ΠΈ 50 ΠΌΠΊΠ³/ΠΌΠ» ΠΊΡΡΠΊΡΠΌΠΈΠ½ ΡΠ²Π΅Π»ΠΈΡΠΈΠ²Π°Π΅Ρ ΡΡΠΎΠ²Π½ΠΈ Π±Π΅Π»ΠΊΠ° RASSF1A (β = 26,53 % ΠΈ 47,35 %, ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎ), Bax (β = 48,79 % ΠΈ 386,15 %) ΠΈ ΠΊΠ°ΡΠΏΠ°Π·Ρ-3 (β = 1678,51 % ΠΈ 1871,889 %).ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΊΡΡΠΊΡΠΌΠΈΠ½Π° Π² ΠΊΠ»Π΅ΡΠΊΠΈ CSA03 ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎ ΡΠΌΠ΅Π½ΡΡΠ°Π»ΠΎ ΡΠΎΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΡΠ°ΠΊΠ° ΠΌΠΎΠ»ΠΎΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ in vitro Π·Π° ΡΡΠ΅Ρ ΡΠ΅Π°ΠΊΡΠΈΠ²Π°ΡΠΈΠΈ RASSF1A Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ Π³Π΅Π½Π°-ΡΡΠΏΡΠ΅ΡΡΠΎΡΠ° ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ ΠΈ ΠΏΠΎΠ²ΡΡΠ°Π»ΠΎ ΡΡΠΎΠ²Π΅Π½Ρ Π±Π΅Π»ΠΊΠ° Bax Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΈΠ½Π΄ΡΠΊΡΠΈΠΈ Π°ΠΏΠΎΠΏΡΠΎΠ·Π° (caspase-3).