Pfaffian representations of cubic surfaces

Let K be a field of characteristic zero. We describe an algorithm which requires a homogeneous polynomial F of degree three in K[x_0,x_1,x_2,x_3] and a zero A of F in P^3_K and ensures a linear pfaffian representation of V(F) with entries in K[x_0,x_1,x_2,x_3], under mild assumptions on F and A. We use this result to give an explicit construction of (and to prove the existence of) a linear pfaffian representation of V(F), with entries in K'[x_0,x_1,x_2,x_3], being K' an algebraic extension of K of degree at most six. An explicit example of such a construction is given.Comment: 17 pages. Expanded with some remarks. Published with minor corrections in Geom. Dedicat

Blastic plasmacytoid dendritic cell neoplasm: Genomics mark epigenetic dysregulation as a primary therapeutic target

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic malignancy for which there is still no effective B therapy. In order to identify genetic alterations useful for a new treatment design, we used whole-exome sequencing to analyze 14 BPDCN patients and the patient-derived CAL-1 cell line. The functional enrichment analysis of mutational data reported the epigenetic regulatory program to be the most significantly undermined (P<0.0001). In particular, twenty-five epigenetic modifiers were found mutated (e.g. ASXL1, TET2, SUZ12, ARID1A, PHF2, CHD8); ASXL1 was the most frequently affected (28.6% of cases). To evaluate the impact of the identified epigenetic mutations at the gene-expression and Histone H3 lysine 27 trimethylation/acetylation levels, we performed additional RNA and pathology tissue-chromatin immunoprecipitation sequencing experiments. The patients displayed enrichment in gene signatures regulated by methylation and modifiable by decitabine administration, shared common H3K27-acetylated regions, and had a set of cell-cycle genes aberrantly up-regulated and marked by promoter acetylation. Collectively, the integration of sequencing data showed the potential of a therapy based on epigenetic agents. Through the adoption of a preclinical BPDCN mouse model, established by CAL-1 cell line xenografting, we demonstrated the efficacy of the combination of the epigenetic drugs 5’-azacytidine and decitabine in controlling disease progression in vivo

10 ps timing with highly irradiated 3D trench silicon pixel sensors

In this paper the results of a beam test characterization campaign of 3D trench silicon pixel sensors are presented. A time resolution in the order of 10 ps was measured both for non-irradiated and irradiated sensors up to a fluence of $2.5 \cdot 10^{16}\,1\,MeV\, n_{eq}\,cm^{-2}$. This feature and a detection efficiency close to $99\%$ make this sensors one of the best candidates for 4D tracking detectors in High-Energy-Physics experiments.Comment: Prepared for submission to JINST, IWORID 202

Transnational strategy on the sustainable management and responsible use of non-native trees in the Alpine Space

Abstract Non-native tree species – defined as those species intentionally or unintentionally introduced by humans – have long been a part of the Alpine Space, providing numerous benefits, but also posing a potential threat to native biodiversity and related ecosystem services. Compared to the urban space where non-native trees comprise most tree species, the number of non-native trees in forests and plantations is relatively low. To evaluate potential risks and benefits of non-native trees in the Alpine Space, a transnational strategy for the responsible use and management of non-native trees is needed. The goals of the strategy are to tailor management practices for a sustainable and responsible use or admixture of non-native trees, to reduce the risks connected with the invasive potential of some non-native tree species, to help forests and urban areas to adapt to climate change, and to improve coordination and cooperation regarding best practices between different regions of the Alpine Space. A proposal was developed in a four-step process including expert-based assessment, stakeholder mapping, an extensive data review, and a public consultation. For implementing the strategy fully, strong collaboration among diverse stakeholders is anticipated and robust governance and an adequate long-term and fair funding scheme is needed

Prioritizing management actions for invasive non-native plants through expert-based knowledge and species distribution models

Given the high number of non-native plants that are being introduced worldwide and the time required to process formal pest risk analyses, a framework for the prioritization of management actions is urgently required. We therefore propose a framework for a replicable and standardized prioritization for management actions (eradication, control and monitoring) of invasive non-native plants, combining expert knowledge, current and future climatic suitability estimated by species distribution models (SDMs), clustering and ordination techniques. Based on expert consultation and using Italy as case study, invasive non-native plant species were selected and three categories of management actions were identified: eradication, control and containment, and monitoring. Finally, two further classes of priorities were proposed for each of the management actions: “high” and “low” priority. Overall, SDMs highlighted a high and very high suitability for Continental and Mediterranean bioregions for most invasive plants. Cluster analysis revealed three distinct clusters with varying levels of suitability for the Italian bioregions. Cluster 1 exhibited a higher suitability across all Italian bioregions, whereas non-native plants grouped in Cluster 2 predominantly featured high suitability in Mediterranean areas. Finally, Cluster 3 showed the lowest suitability values. Two ordination analysis highlighted the variability in bioclimatic suitability for each non-native plant within each cluster, as well as their current distribution pattern. Lastly, a third ordination, integrating bioclimatic suitability and spatial patterns, has allowed the differentiation of management actions for each non-native plant at both national and bioregional scales. Specifically, seven non-native plants were earmarked for eradication action, six for monitoring action, while the remaining species were deemed suitable for control and containment. Our results and the methodology proposed meet the demand for replicable new early warning tools; that is to predict the location of new outbreaks, to establish priorities for eradication, control and containment, and to monitor invasive non-native species