Effective medium approach for stiff polymer networks with flexible cross-links

Recent experiments have demonstrated that the nonlinear elasticity of in vitro networks of the biopolymer actin is dramatically altered in the presence of a flexible cross-linker such as the abundant cytoskeletal protein filamin. The basic principles of such networks remain poorly understood. Here we describe an effective medium theory of flexibly cross-linked stiff polymer networks. We argue that the response of the cross-links can be fully attributed to entropic stiffening, while softening due to domain unfolding can be ignored. The network is modeled as a collection of randomly oriented rods connected by flexible cross-links to an elastic continuum. This effective medium is treated in a linear elastic limit as well as in a more general framework, in which the medium self-consistently represents the nonlinear network behavior. This model predicts that the nonlinear elastic response sets in at strains proportional to cross-linker length and inversely proportional to filament length. Furthermore, we find that the differential modulus scales linearly with the stress in the stiffening regime. These results are in excellent agreement with bulk rheology data.Comment: 12 pages, 8 figure

The bend stiffness of S-DNA

We formulate and solve a two-state model for the elasticity of nicked, double-stranded DNA that borrows features from both the Worm Like Chain and the Bragg--Zimm model. Our model is computationally simple, and gives an excellent fit to recent experimental data through the entire overstretching transition. The fit gives the first value for the bending stiffness of the overstretched state as about 10 nm*kbt, a value quite different from either B-form or single-stranded DNA.Comment: 7 pages, 1 figur

Theoretical insights into the RR Lyrae K-band Period-Luminosity relation

Based on updated nonlinear, convective pulsation models computed for several values of stellar mass, luminosity and metallicity, theoretical constraints on the K-band Period-Luminosity (PLK) relation of RR Lyrae stars are presented. We show that for each given metal content the predicted PLK is marginally dependent on uncertainties of the stellar mass and/or luminosity. Then, by considering the RR Lyrae masses suggested by evolutionary computations for the various metallicities, we obtain that the predicted infrared magnitude M_K over the range 0.0001< Z <0.02 is given by the relation MK=0.568-2.071logP+0.087logZ-0.778logL/Lo, with a rms scatter of 0.032 mag. Therefore, by allowing the luminosities of RR Lyrae stars to vary within the range covered by current evolutionary predictions for metal-deficient (0.0001< Z <0.006) horizontal branch models, we eventually find that the infrared Period-Luminosity- Metallicity (PLZK) relation is MK=0.139-2.071(logP+0.30)+0.167logZ, with a total intrinsic dispersion of 0.037 mag. As a consequence, the use of such a PLZK relation should constrain within +-0.04 mag the infrared distance modulus of field and cluster RR Lyrae variables, provided that accurate observations and reliable estimates of the metal content are available. Moreover, we show that the combination of K and V measurements can supply independent information on the average luminosity of RR Lyrae stars, thus yielding tight constraints on the input physics of stellar evolution computations. Finally, for globular clusters with a sizable sample of first overtone variables, the reddening can be estimated by using the PLZK relation together with the predicted MV-logP relation at the blue edge of the instability strip (Caputo et al. 2000).Comment: 8 pages, including 5 postscript figures, accepted for publication on MNRA

Geometry and the onset of rigidity in a disordered network

Disordered spring networks that are undercoordinated may abruptly rigidify when sufficient strain is applied. Since the deformation in response to applied strain does not change the generic quantifiers of network architecture - the number of nodes and the number of bonds between them - this rigidity transition must have a geometric origin. Naive, degree-of-freedom based mechanical analyses such as the Maxwell-Calladine count or the pebble game algorithm overlook such geometric rigidity transitions and offer no means of predicting or characterizing them. We apply tools that were developed for the topological analysis of zero modes and states of self-stress on regular lattices to two-dimensional random spring networks, and demonstrate that the onset of rigidity, at a finite simple shear strain $\gamma^\star$, coincides with the appearance of a single state of self stress, accompanied by a single floppy mode. The process conserves the topologically invariant difference between the number of zero modes and the number of states of self stress, but imparts a finite shear modulus to the spring network. Beyond the critical shear, we confirm previously reported critical scaling of the modulus. In the sub-critical regime, a singular value decomposition of the network's compatibility matrix foreshadows the onset of rigidity by way of a continuously vanishing singular value corresponding to nascent state of self stress.Comment: 6 pages, 6 figue

Nonlinear elasticity of composite networks of stiff biopolymers with flexible linkers

Motivated by recent experiments showing nonlinear elasticity of in vitro networks of the biopolymer actin cross-linked with filamin, we present an effective medium theory of flexibly cross-linked stiff polymer networks. We model such networks by randomly oriented elastic rods connected by flexible connectors to a surrounding elastic continuum, which self-consistently represents the behavior of the rest of the network. This model yields a crossover from a linear elastic regime to a highly nonlinear elastic regime that stiffens in a way quantitatively consistent with experiment.Comment: 4 pages, 3 figure

Direct Distances to Cepheids in the Large Magellanic Cloud: Evidence for a Universal Slope of the Period-Luminosity Relation up to Solar Abundance

We have applied the infrared surface brightness (ISB) technique to derive distances to 13 Cepheids in the LMC which span a period range from 3 to 42 days. From the absolute magnitudes of the variables calculated from these distances, we find that the LMC Cepheids define tight period-luminosity relations in the V, I, W, J and K bands which agree exceedingly well with the corresponding Galactic PL relations derived from the same technique, and are significantly steeper than the LMC PL relations in these bands observed by the OGLE-II Project in V, I and W, and by Persson et al. in J and K. We find that the tilt-corrected true distance moduli of the LMC Cepheids show a significant dependence on period, which hints at a systematic error in the ISB technique related to the period of the stars. We identify as the most likely culprit the p-factor which converts the radial into pulsational velocities; our data imply a much steeper period dependence of the p-factor than previously thought, and we derive p=1.58 (+/-0.02) -0.15 (+/-0.05) logP as the best fit from our data, with a zero point tied to the Milky Way open cluster Cepheids. Using this revised p-factor law, the period dependence of the LMC Cepheid distance moduli disappears, and at the same time the Milky Way and LMC PL relations agree among themselves, and with the directly observed LMC PL relations, within the 1 sigma uncertainties. Our main conclusion is that the previous, steeper Galactic PL relations were caused by an erroneous calibration of the p-factor law, and that there is now evidence that the slope of the Cepheid PL relation is independent of metallicity up to solar metallicity, in both optical, and near-infrared bands.Comment: ApJ accepte

BVRIJK light curves and radial velocity curves for selected Magellanic Cloud Cepheids

We present high precision and well sampled BVRIJK light curves and radial velocity curves for a sample of five Cepheids in the SMC. In addition we present radial velocity curves for three Cepheids in the LMC. The low metallicity (Fe/H ~ -0.7) SMC stars have been selected for use in a Baade-Wesselink type analysis to constrain the metallicity effect on the Cepheid Period-Luminosity relation. The stars have periods of around 15 days so they are similar to the Cepheids observed by the Extragalactic Distance Scale Key Project on the Hubble Space Telescope. We show that the stars are representative of the SMC Cepheid population at that period and thus will provide a good sample for the proposed analysis. The actual Baade-Wesselink analysis are presented in a companion paper.Comment: Accepted for publication in A&A, 23 pages, 10 figures, data tables will be made available electronically from the CD

Iceman Survived due to Cooling Device

Although mild hypothermia treatment is part of the standard postresuscitation care today, no standard method for treatment of accidental severe hypothermia has been yet established. Different strategies including invasive and noninvasive methods have been described in the literature. We present the case of a 75-year-old man with accidental severe hypothermia (23°C) and demonstrate that using a surface cooling device with automatic controlled temperature feedback mechanism (ArcticSun2000 Medivance, Louisville, Colorado, USA) is an effective and safe method for controlled rewarming in this life-threatening setting