24 research outputs found
Positive Association between Aspirin-Intolerant Asthma and Genetic Polymorphisms of FSIP1: a Case-Case Study
Get PDF<p>Abstract</p> <p>Background</p> <p>Aspirin-intolerant asthma (AIA), which is caused by non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, causes lung inflammation and reversal bronchi reduction, leading to difficulty in breathing. Aspirin is known to affect various parts inside human body, ranging from lung to spermatogenesis. <it>FSIP1</it>, also known as <it>HDS10</it>, is a recently discovered gene that encodes fibrous sheath interacting protein 1, and is regulated by amyloid beta precursor protein (APP). Recently, it has been reported that a peptide derived from APP is cleaved by α disintegrin and metalloproteinase 33 (<it>ADAM33</it>), which is an asthma susceptibility gene. It has also been known that the <it>FSIP1 </it>gene is expressed in airway epithelium.</p> <p>Objectives</p> <p>Aim of this study is to find out whether <it>FSIP1 </it>polymorphisms affect the onset of AIA in Korean population, since it is known that AIA is genetically affected by various genes.</p> <p>Methods</p> <p>We conducted association study between 66 single nucleotide polymorphisms (SNPs) of the <it>FSIP1 </it>gene and AIA in total of 592 Korean subjects including 163 AIA and 429 aspirin-tolerant asthma (ATA) patients. Associations between polymorphisms of <it>FSIP1 </it>and AIA were analyzed with sex, smoking status, atopy, and body mass index (BMI) as covariates.</p> <p>Results</p> <p>Initially, 18 SNPs and 4 haplotypes showed associations with AIA. However, after correcting the data for multiple testing, only one SNP showed an association with AIA (corrected <it>P</it>-value = 0.03, OR = 1.63, 95% CI = 1.23-2.16), showing increased susceptibility to AIA compared with that of ATA cases. Our findings suggest that <it>FSIP1 </it>gene might be a susceptibility gene for aspirin intolerance in asthmatics.</p> <p>Conclusion</p> <p>Although our findings did not suggest that SNPs of <it>FSIP1 </it>had an effect on the reversibility of lung function abnormalities in AIA patients, they did show significant evidence of association between the variants in <it>FSIP1 </it>and AIA occurrence among asthmatics in a Korean population.</p
Genetic variants in ADAM33 are associated with airway inflammation and lung function in COPD
Full text linkElectrochemical deposition of silver nanoparticle and polymerization of pyrrole on fabrics via conducting multiwall carbon nanotubes
Get PDFSimvastatin up-regulates adenosine deaminase and suppresses osteopontin expression in COPD patients through an IL-13-dependent mechanism
Full text linkA validation study of a virtual‐based haptic system for endoscopic sinus surgery training
No full textEVALUATION OF INTERACTION BETWEEN MECHANICAL PARAMETERS OF UNBOUND GRANULAR MATERIALS IN BASE LAYER OF ASPHALT PAVEMENT
No full textIn a majority of methods used for designing asphalt pavements, the base and
sub-base layers have not received enough attention; instead, most researches
have focused on the asphalt layers. These layers play a key role in reducing
stress on the base layer. Light Weight Deflectometer (LWD) test is commonly
used for assessing the bearing capacity of unbound layers of pavements. The
present study aims to investigate the simultaneous effects of different variables such as sample thickness, wet content, weight, and compaction on the base layer surface modulus and deflection through LWD test results on the 150\times150\times60 cm sample. The results indicated that the maximum compaction value was 97\% with a thickness of 40 cm and the minimum compaction value was 10 Kg weight with 20 cm thickness. Furthermore, according to the findings, an increase in the compaction and thickness of the layer led to a decrease in the deflection and an increase in the mass of weight; however, moisture did not significantly influence the mentioned factor
