14 research outputs found
High cytotoxicity and apoptotic effects of natural bioactive benzofuran derivative on the MCF-7 breast cancer cell line
No full textThis study was focused on evaluation of the cytotoxicity and apoptotic affects of benzofuran derivative on MCF-7 breast cancer cell line. This effective compound was isolated from the root of Petasites hybridus plant. For experiments, the MCF-7 cells were treated with several concentrations (0-500μM) of 1-(6-hydroxy-2-isopropenyl-1-benzofuran-5-yl)-1-ethanone 1 at different times. In this study, test of neutral red was also employed for cytotoxicity assay and quantity of P53, P21. Bax genes expression was analyzed using Real-Time PCR and ELISA techniques. Results show that compound 1 has cytotoxicity and apoptotic effects on Human breast cancer (Michigan Cancer Foundation-7) MCF-7 cells. © 2015 Bentham Science Publishers
One-pot three-component reaction of ninhydrin, 1,3-dicarbonyl compounds, and primary amines to afford indeno[1,2-b]pyrrol-4(1H)-ones
No full textGreen synthesis and antioxidant activity of novel series of benzofurans from euparin extracted of Petasites hybridus
No full textA one-pot synthesis of functionalized 4,5-bis(phenylimino)-1,3-thiazolidine-2-thiones from primary amines, CS2 and N,N’-diphenyloxalimidoyl dichloride
No full textProduction of benzazepine derivatives via four-component reaction of isatins: study of antioxidant activity
No full textSynthesis of New Functionally Substituted Aryl- and Hetarylcarbamates Based on Ninhydrin
No full textSynthesis of fungicidally active succinate dehydrogenase inhibitors with novel difluoromethylated heterocyclic acid moieties
No full textA Facile Synthesis and Theoretical Study of Novel Stable Heterocyclic Phosphorus Ylides Containing a 2,4-Dimethyl-3-acetyl Moiety
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