59 research outputs found

    CD8+/TCR− graft facilitating cells enhance HSC function via induction of low levels of TNF-α

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    Calcul analytique du champ engendré par des aimants dans l'entrefer d'une machine à rotor denté

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    The method of juxtaposition of sub-domains described here is of great interest in the field calculation of electric machines provided that the geometry and the boundary conditions are simple. Its implementation is very fast and easy, and the results (total and partial fluxes, flux densities) can be obtained in a few seconds with a good and measurable accuracy.La méthode de juxtaposition de sous-domaines exposée ici est d'un grand intérêt dans les calculs de champ des machines dont la géométrie et les conditions aux limites sont suffisamment simples. La mise en ceuvre en est facile et très rapide et les résultats (flux total et partiel, inductions) sont obtenus en quelques secondes avec une précision mesurable très satisfaisante

    Equivalence between the method of magnetic images and the variable separation method in the study of some slotless surface permanent magnet synchronous machines

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    In the present paper, the equivalence between the magnetic images method and the classical variable separation method is set up. These methods are separately applied to calculate the magnetic scalar potentials and the magnetic vector potentials in the air-gap of some cylindrical synchronous machines, excited by surface permanent magnets with radial and/or azimuthal magnetisation, and without polar pieces. The rotor and the stator are assumed slotless, and the whole electric machine non saturated. The expressions of the magnetic scalar potentials of each method are interpreted, and their equivalence is established. The Mayn purpose of this paper is then the demonstration that the magnetic images method is applicable for the study of simplified synchronous machines. The interest of the magnetic images use in comparison with the variable separation method is shown

    Parameters affecting photodynamic activity of Foscan® or meta-tetra(hydroxyphenyl)chlorin (mTHPC

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    Abstract. In vitro photodynamic activity of Foscan or meta-tetra(hydroxyphenyl)chlorin (mTHPC) was approximately five times lower in the presence of protein in comparison with serum-free medium. Photocytotoxicity does not depend on the incubation time of the dye with cells. The in vitro results are discussed from the point of view of photodynamically active aggregated species. The photodynamic activity of mTHPC was elevated in vivo by macroscopic measurement of the necrosis depth after tumoral resection using an in vivo staining procedure with Evans blue dye. Only tumours from treated animals presented measurable necrosis areas, mostly localised in the surface around the irradiated site with a mean depth of 3.0 0.3 mm. The photodynamic activity was found to be significantly higher when using low irradiance (32 mW/cm 2 ) than when using a higher one (160 mW/cm 2 ). These results were not related to intratumoral mTHPC photodestruction analysed by in vivo fluorescence spectral analysis

    A delay in bone marrow transplantation after partial conditioning improves engraftment

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    Background. In the present study we examined the effect of the timing of marrow infusion on engraftment in nonmyeloablatively conditioned mice.Methods. B10 mice were conditioned with decreasing doses of total body irradiation (TBI) and reconstituted with bone marrow cells (BMCs) from major histocompatibility complex-disparate donor B10.BR mice at 0 or 6 hr, or on days 1, 2, 3, 4, 5, 8, and 12 with respect to TBI.Results. After undergoing conditioning with 700 cGy TBI and transplantation with 15 x 10(6) BMCs, 100% of recipients engrafted if the marrow was infused between 0 and 4 days after TBI. For lower doses of TBI, a delay in infusion of the marrow after TBI conditioning was associated with a significant increase in engraftment. Significantly less engraftment was achieved in animals conditioned with 600 cGy TBI if the marrow was infused at 0 or 6 hr compared with a 1- to 4-day delay. When the TBI was decreased to 500 cGy, engraftment occurred only when the transplant was performed between days 2 and 8. The highest proportion of recipients engrafted when the marrow was infused on day 4. This enhanced engraftment after a delay in marrow infusion is associated with a significant reduction in host mixed lymphocyte reaction reactivity and is correlated inversely with serum levels of interleukin-6 in the recipient.Conclusions. These data demonstrate for the first time that a delay between conditioning and marrow infusion significantly improves allogeneic engraftment in nonmyeloablatively conditioned recipients and reduces the total conditioning required
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