47 research outputs found
A Random Matrix Model of Adiabatic Quantum Computing
We present an analysis of the quantum adiabatic algorithm for solving hard
instances of 3-SAT (an NP-complete problem) in terms of Random Matrix Theory
(RMT). We determine the global regularity of the spectral fluctuations of the
instantaneous Hamiltonians encountered during the interpolation between the
starting Hamiltonians and the ones whose ground states encode the solutions to
the computational problems of interest. At each interpolation point, we
quantify the degree of regularity of the average spectral distribution via its
Brody parameter, a measure that distinguishes regular (i.e., Poissonian) from
chaotic (i.e., Wigner-type) distributions of normalized nearest-neighbor
spacings. We find that for hard problem instances, i.e., those having a
critical ratio of clauses to variables, the spectral fluctuations typically
become irregular across a contiguous region of the interpolation parameter,
while the spectrum is regular for easy instances. Within the hard region, RMT
may be applied to obtain a mathematical model of the probability of avoided
level crossings and concomitant failure rate of the adiabatic algorithm due to
non-adiabatic Landau-Zener type transitions. Our model predicts that if the
interpolation is performed at a uniform rate, the average failure rate of the
quantum adiabatic algorithm, when averaged over hard problem instances, scales
exponentially with increasing problem size.Comment: 9 pages, 7 figure
Comparison of PBO solvers in a dependency solving domain
Linux package managers have to deal with dependencies and conflicts of
packages required to be installed by the user. As an NP-complete problem, this
is a hard task to solve. In this context, several approaches have been pursued.
Apt-pbo is a package manager based on the apt project that encodes the
dependency solving problem as a pseudo-Boolean optimization (PBO) problem. This
paper compares different PBO solvers and their effectiveness on solving the
dependency solving problem.Comment: In Proceedings LoCoCo 2010, arXiv:1007.083
Sacituzumab govitecan in metastatic triple-negative breast cancer
BACKGROUND: Patients with metastatic triple-negative breast cancer have a poor prognosis. Sacituzumab govitecan is an antibody-drug conjugate composed of an antibody targeting the human trophoblast cell-surface antigen 2 (Trop-2), which is expressed in the majority of breast cancers, coupled to SN-38 (topoisomerase I inhibitor) through a proprietary hydrolyzable linker. METHODS In this randomized, phase 3 trial, we evaluated sacituzumab govitecan as compared with single-agent chemotherapy of the physician's choice (eribulin, vinorelbine, capecitabine, or gemcitabine) in patients with relapsed or refractory metastatic triple-negative breast cancer. The primary end point was progression-free survival (as determined by blinded independent central review) among patients without brain metastases. RESULTS A total of 468 patients without brain metastases were randomly assigned to receive sacituzumab govitecan (235 patients) or chemotherapy (233 patients). The median age was 54 years; all the patients had previous use of taxanes. The median progression-free survival was 5.6 months (95% confidence interval [CI], 4.3 to 6.3; 166 events) with sacituzumab govitecan and 1.7 months (95% CI, 1.5 to 2.6; 150 events) with chemotherapy (hazard ratio for disease progression or death, 0.41; 95% CI, 0.32 to 0.52; P<0.001). The median overall survival was 12.1 months (95% CI, 10.7 to 14.0) with sacituzumab govitecan and 6.7 months (95% CI, 5.8 to 7.7) with chemotherapy (hazard ratio for death, 0.48; 95% CI, 0.38 to 0.59; P<0.001). The percentage of patients with an objective response was 35% with sacituzumab govitecan and 5% with chemotherapy. The incidences of key treatment-related adverse events of grade 3 or higher were neutropenia (51% with sacituzumab govitecan and 33% with chemotherapy), leukopenia (10% and 5%), diarrhea (10% and <1%), anemia (8% and 5%), and febrile neutropenia (6% and 2%). There were three deaths owing to adverse events in each group; no deaths were considered to be related to sacituzumab govitecan treatment. CONCLUSIONS Progression-free and overall survival were significantly longer with sacituzumab govitecan than with single-agent chemotherapy among patients with metastatic triple-negative breast cancer. Myelosuppression and diarrhea were more frequent with sacituzumab govitecan
Where do the immune checkpoint inhibitors stand in the management of triple negative breast cancer?
Composing Symmetry Propagation and Effective Symmetry Breaking for SAT Solving
International audienc
Failed literal detection for QBF
Abstract. Failed literal detection (FL) in SAT is a powerful approach for preprocessing. The basic idea is to assign a variable as assumption. If boolean constraint propagation (BCP) yields an empty clause then the negated assumption is necessary for satisfiability. Whereas FL is common in SAT, it cannot easily be applied to QBF due to universal quantification. We present two approaches for FL to preprocess prenex CNFs. The first one is based on abstraction where certain universal variables are treated as existentially quantified. Second we combine QBF-specific BCP (QBCP) in FL with Q-resolution to validate assignments learnt by FL. Finally we compare these two approaches to a third common approach based on SAT. It turns out that the three approaches are incomparable. Experimental evaluation demonstrates that FL for QBF can improve the performance of search- and elimination-based QBF solvers.