Hydrodynamic modelling with unstructured grid using D-Flow-FM: case study Afferden-Deest

Accurate predictions of water levels play an important role in the management of flood safety. Nowadays, it has become common practice to use multi-dimensional numerical hydrodynamic models for such purposes. Currently, two model types are the standard tools in the Netherlands, namely WAQUA/TRIWAQ (Rijkswaterstaat, 2012) and Delft3D (Deltares, 2014). WAQUA and Delft3D are both based on a structured curvilinear grid, which can follow large-scale topographical changes and uses similar grid resolution throughout the entire computational domain. Drawbacks of the structured curvilinear grid approach are that elevation jumps in the river's topography may lead to unrealistic staircase representations in the model, and the inner bends of meandering rivers gridlines may become focussed to unnecessarily small grid cells (Kernkamp et al., 2011). To improve on these issues, Deltares is developing the unstructured-grid-based hydrodynamic model Flexible Mesh (also referred to as “D-Flow-FM”). The unstructured grid approach enables the user to use a spatially variable grid resolution. By combining curvilinear grid cells with triangular grid cells, the modeller can increase grid resolution on the locations where, because of local topographical variations, it is most desired. In this study, modelling results of Flexible Mesh and WAQUA are presented for a selected river reach near Afferden-Deest and benefits of local grid refinements in Flexible Mesh are demonstrated

On the importance of discharge variability in the morphodynamic modeling of rivers

River morphodynamics and sediment transportRiver morphology and morphodynamic

Анализ составляющих теплового баланса системы "прокатный стан - прокатываемая полоса" и пути снижения энергозатрат в процессе сортовой прокатки

Выполнен анализ составляющих теплового баланса системы «прокатный стан – прокатываемая полоса». Рассмотрены основные направления решения температурной задачи сортовой прокатки. Предложен ряд мероприятий, позволяющих снизить расход энергоресурсов на прокатку и уменьшить расходную часть теплового баланса системы «прокатный стан – прокатываемая полоса»

Rationalisation of the Differences between APOBEC3G Structures from Crystallography and NMR Studies by Molecular Dynamics Simulations

The human APOBEC3G (A3G) protein is a cellular polynucleotide cytidine deaminase that acts as a host restriction factor of retroviruses, including HIV-1 and various transposable elements. Recently, three NMR and two crystal structures of the catalytic deaminase domain of A3G have been reported, but these are in disagreement over the conformation of a terminal β-strand, β2, as well as the identification of a putative DNA binding site. We here report molecular dynamics simulations with all of the solved A3G catalytic domain structures, taking into account solubility enhancing mutations that were introduced during derivation of three out of the five structures. In the course of these simulations, we observed a general trend towards increased definition of the β2 strand for those structures that have a distorted starting conformation of β2. Solvent density maps around the protein as calculated from MD simulations indicated that this distortion is dependent on preferential hydration of residues within the β2 strand. We also demonstrate that the identification of a pre-defined DNA binding site is prevented by the inherent flexibility of loops that determine access to the deaminase catalytic core. We discuss the implications of our analyses for the as yet unresolved structure of the full-length A3G protein and its biological functions with regard to hypermutation of DNA