76 research outputs found
Molecular Docking and Biophysical Studies for Antiproliferative Assessment of Synthetic Pyrazolopyrimidinones Tethered with Hydrazide-Hydrazones.
Chemotherapy represents the most applied approach to cancer treatment. Owing to the frequent onset of chemoresistance and tumor relapses, there is an urgent need to discover novel and more effective anticancer drugs. In the search for therapeutic alternatives to treat the cancer disease, a series of hybrid pyrazolo[3,4-d]pyrimidin-4(5H)-ones tethered with hydrazide-hydrazones, 5a–h, was synthesized from condensation reaction of pyrazolopyrimidinone-hydrazide 4 with a series of arylaldehydes in ethanol, in acid catalysis. In vitro assessment of antiproliferative effects against MCF-7 breast cancer cells, unveiled that 5a, 5e, 5g, and 5h were the most effective compounds of the series and exerted their cytotoxic activity through apoptosis induction and G0/G1 phase cell-cycle arrest. To explore their mechanism at a molecular level, 5a, 5e, 5g, and 5h were evaluated for their binding interactions with two well-known anticancer targets, namely the epidermal growth factor receptor (EGFR) and the G-quadruplex DNA structures. Molecular docking simulations highlighted high binding affinity of 5a, 5e, 5g, and 5h towards EGFR. Circular dichroism (CD) experiments suggested 5a as a stabilizer agent of the G-quadruplex from the Kirsten ras (KRAS) oncogene promoter. In the light of these findings, we propose the pyrazolo-pyrimidinone scaffold bearing a hydrazide-hydrazone moiety as a lead skeleton for designing novel anticancer compound
Quantum flux effects on the energy spectra and thermo-magnetic properties in 2D Schrodinger equation with Mobius square potential
A 2D Schrodinger equation with interacting Mobius square potential model is
solved using Nikiforov-Uvarov Functional Analysis (NUFA) formalism. The energy
spectra and the corresponding wave function for the linearly and exponentially
varying quantum magnetic flux are obtained analytically in a closed form. The
evaluated energy spectra are used to obtain an expression for the partition
functions for the two cases comprises of the linearly and exponentially varying
quantum magnetic flux and vis-a-vis is use to evaluate other thermodynamic and
magnetic properties for the system. The results are used to study the free
energy, mean energy, the entropy, specific heat, magnetization, magnetic
susceptibility and the persistent current of the system. The numerical bound
state energies are computed.Comment: 39 Pages, 64 figure
Exact solutions of κ-dependent Schrödinger equation with quantum pseudo-harmonic oscillator and its applications for the thermodynamic properties in normal and superstatistics
The effects of the curvature parameters on the energy eigenvalues and thermodynamic properties of quantum pseudoharmonic oscillator are investigated within the framework of nonrelativistic quantum mechanics. By employing Nikiforov-Uvarov method, the energy spectra are obtained and used to study the ordinary statistics and q-deformed superstatistics as a function of temperature in the presence and absence of the curvature parameters. It is shown that the q-deformed supertatistics properties of the quantum pseudoharmonic oscillator reduce to the ordinary statistical properties in the absence of the deformation parameter. Finally, our results are illustrated graphically to show the behaviour of the energy spectra and thermodynamic properties for the three curvature parameters:κ=−1,κ=1andκ=0
Formation and interactions of cold and ultracold molecules: new challenges for interdisciplinary physics
Progress on researches in the field of molecules at cold and ultracold
temperatures is reported in this review. It covers extensively the experimental
methods to produce, detect and characterize cold and ultracold molecules
including association of ultracold atoms, deceleration by external fields and
kinematic cooling. Confinement of molecules in different kinds of traps is also
discussed. The basic theoretical issues related to the knowledge of the
molecular structure, the atom-molecule and molecule-molecule mutual
interactions, and to their possible manipulation and control with external
fields, are reviewed. A short discussion on the broad area of applications
completes the review.Comment: to appear in Reports on Progress in Physic
Giant primary adrenal hydatid cyst presenting with arterial hypertension: a case report and review of the literature
<p>Abstract</p> <p>Introduction</p> <p>A primary hydatid cyst of the adrenal gland is still an exceptional localization. The adrenal gland is an uncommon site even in Morocco, where echinococcal disease is endemic.</p> <p>Case presentation</p> <p>We report the case of a 64-year-old Moroccan man who presented with the unusual symptom of arterial hypertension associated with left flank pain. Computed tomography showed a cystic mass of his left adrenal gland with daughter cysts filing the lesion (Type III). Despite his negative serology tests, the diagnosis of a hydatid cyst was confirmed on surgical examination. Our patient underwent surgical excision of his left adrenal gland with normalization of blood pressure. No recurrence has occurred after 36 months of follow-up.</p> <p>Conclusion</p> <p>There are two remarkable characteristics of this case report; the first is the unusual location of the cyst, the second is the association of an adrenal hydatid cyst with arterial hypertension, which has rarely been reported in the literature.</p
Waterlogging-induced changes in fermentative metabolism in roots and nodules of soybean genotypes
Effects of glucose on the uptake and metabolism of glycine in pakchoi (Brassica chinensis L.) exposed to various nitrogen sources
Transcriptome profiling analysis for two Tibetan wild barley genotypes in responses to low nitrogen
Exploiting the interactions between poly-histidine fusion tags and immobilized metal ions
Mediterraneo. Un dialogo fra le due sponde.
Questa raccolta di saggi è il primo frutto della collaborazione fra un gruppo di docenti e ricercatori della Facoltà di diritto e di scienze politiche dell'Università di Tunisi El Manar e gli studiosi italiani che hanno dato vita al centro di filosofia del diritto internazionale Jura Gentium, che opera presso il Dipartimento di teoria e storia del diritto dell'Università di Firenze. Il tema centrale del volume è l'esigenza di un dialogo culturale fra le due sponde del Mediterraneo - quella europea e quella arabo-islamica - che coinvolga le società civili dei rispettivi paesi in un ripensamento della storia e del destino del mondo mediterraneo.
Un recupero dello "spazio mediterraneo" potrebbe fornire risorse di consapevolezza culturale e politica capaci di produrre effetti identitari per gli attori di entrambe le sponde del Mediterraneo. L'impegno dei movimenti giovanili, delle associazioni culturali, dei sindacati, delle università , delle organizzazioni femminili potrebbe dare frutti insperati e mostrare che un altro Mediterraneo è possibile
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