Numerical simulation tests with light dynamical quarks

Two degenerate flavours of quarks are simulated with small masses down to about one fifth of the strange quark mass by using the two-step multi-boson (TSMB) algorithm. The lattice size is 8^3 x 16 with lattice spacing about 0.27fm which is not far from the N_t=4 thermodynamical cross-over line. Autocorrelations of different physical quantities are estimated as a function of the quark mass. The eigenvalue spectra of the Wilson-Dirac operator are investigated.Comment: 14 pages, 7 figures, uses svjour.cls; mistake in the autocorrelation of the pion mass corrected, version accepted for publication on Eur. Phys. J.

Coal Mineral Analysis: A Check on Inter-Laboratory Agreement

Four laboratories co-operated to test repeatibility and reproducibility of the semi-quantitive Coal Mineral Analysis (CMA) method. CMA is an instrumented image analysis method which identifies mineral particles in coal by chemical composition (energy dispersive X-ray spectroscopy) and size (scanning electron microscopy). The repeatability of weight percent data was better than 0.2 relative standard deviation for most minerals constituting more than five percent of all coal minerals. The type of mineral had no effect on repeatability. Errors arising from counting statistics were shown to be the major source of bias at a given instrument setting. Inter-laboratory data for the major minerals agreed to within 0.1 relative standard deviation in about 50% of the cases. For other major minerals the relative standard deviation from the inter-laboratory average varied between 0.1 and 0.3. The weight percentages of kaolinite and mixed silicates showed poorer reproducibility than those of quartz and illite. Differences in detector window thickness may have affected discrimination between light elements and, therefore, inter-laboratory agreement of clay minerals data. Means to compensate window thickness effects are suggested

An inexpensive spectroscopic beam monitor for hard X-ray synchrotron applications

We describe an inexpensive beam monitor for hard X-ray synchrotron applications which has good spectroscopic abilities and can operate without cooling. The device is centred on an inexpensive, commercial off-the-shelf, large area (1.2 × 1.2 mm2) Si photodiode operated in single counting mode. Measurements carried out at the HASYLAB synchrotron research facility have shown that it is fully spectroscopic across the energy range 8 keV to 100 keV with a measured energy resolution of ~ 1.2 keV FWHM at room temperature. The measured resolutions were found to be the same under pencil-beam and full-area illumination, indicating uniform crystallinity and stoichiometry of the bulk. The low cost, simplicity and performance of the detector make it suitable for a wider range of applications, e.g., in undergraduate laboratory experiments

Aging and Vascular Disease: A Multidisciplinary Overview

Vascular aging, i.e., the deterioration of the structure and function of the arteries over the life course, predicts cardiovascular events and mortality. Vascular degeneration can be recognized before becoming clinically symptomatic; therefore, its assessment allows the early identification of individuals at risk. This opens the possibility of minimizing disease progression. To review these issues, a search was completed using PubMed, MEDLINE, and Google Scholar from 2000 to date. As a network of clinicians and scientists involved in vascular medicine, we here describe the structural and functional age-dependent alterations of the arteries, the clinical tools for an early diagnosis of vascular aging, and the cellular and molecular events implicated. It emerges that more studies are necessary to identify the best strategy to quantify vascular aging, and to design proper physical activity programs, nutritional and pharmacological strategies, as well as social interventions to prevent, delay, and eventually revert the disease

A sub-50 femtosecond bunch arrival time monitor system for

Abstract A bunch arrival time monitor using the future laser based synchronization system at FLASH has been developed. The signal of a beam pick-up with several GHz bandwidth is sampled by a sub-ps laser pulse using a broadband electro-optical modulator. Bunch arrival time deviations are converted into amplitude modulations of the sampling laser pulses which are then detected by a photo-detector. A resolution of 30 fs could be reached with the capability towards sub-10 fs level. In this paper we describe the design of the optical system and present recent results

Neutral-to-charged current events ratio in atmospheric neutrinos and neutrino oscillations

The atmospheric neutrinos produce isolated neutral pions ($\pi^0$-events) mainly in the neutral current interactions. We propose to study the ratios involving $\pi^0$-events and the events induced mainly by the charged currents. This minimizes uncertainties related to the original neutrino fluxes, and in certain cases, also to the cross-sections. Experimental study of these ratios will allow one to check the oscillation solution of the atmospheric neutrino problem and to identify the channel of oscillations. Illustrative analysis of existing data is presented.Comment: LaTeX, 17 pages, 1 figure. Major changes, illustrative analysis of the Super-Kamiokande results is presente

Exploring semantic verbal fluency patterns and their relationship to age and Alzheimer's disease in adults with Down syndrome

Introduction: Adults with Down syndrome (DS) are at ultra-high risk of developing Alzheimer's disease (AD), characterized by poor episodic memory and semantic fluency in the preclinical phase in the general population. We explored semantic fluency performance in DS and its relationship to age, AD, and blood biomarkers. Methods: A total of 302 adults with DS at baseline and 87 at follow-up from the London Down Syndrome Consortium cohort completed neuropsychological assessments. Blood biomarkers were measured with the single molecule array technique in a subset of 94 participants. Results: Poorer verbal fluency performance was observed as age increases. Number of correct words declined in those with AD compared to those without over 2 years and was negatively correlated with neurofilament light (r = –0.37, P =.001) and glial fibrillary acidic protein (r = –0.31, P =.012). Discussion: Semantic fluency may be useful as an early indicator of cognitive decline and provide additional information on AD-related change, showing associations with biomarkers in DS