9 research outputs found
On the way to glycoprocessing inhibitors. Synthesis of an imidazole-nectrisine-phosphonoacid derivative: a potential glycosyltransferase inhibitor
No full textOn the way to glycoprocessing inhibitors. Synthesis of an imidazole-nectrisine-phosphonoacid derivative: a potential glycosyltransferase inhibitor
No full textEnantioselective synthesis of alpha-fluorinated beta(2)-amino acids
No full textCopyright © 2008 American Chemical SocietyA methodology for the enantioselective synthesis of α-fluorinated β²-amino acids has been developed from readily available carboxylic acids 3. Conversion to the Evan's oxazolidinone followed by enantioselective fluorination and alkylation gave 7 in high diastereomeric excess (>95%). Subsequent removal of the oxazolidinone and amination at the Bn-protected hydroxyl center gave optically active α-fluorinated β²-amino acids.Michael K. Edmonds, Florian H. M. Graichen, James Gardiner, and Andrew D. Abel
The EBI2 signalling pathway plays a role in cellular crosstalk between astrocytes and macrophages
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