The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1

Resveratrol is a cancer preventative agent that is found in red wine. Piceatannol is a closely related stilbene that has antileukaemic activity and is also a tyrosine kinase inhibitor. Piceatannol differs from resveratrol by having an additional aromatic hydroxy group. The enzyme CYP1B1 is overexpressed in a wide variety of human tumours and catalyses aromatic hydroxylation reactions. We report here that the cancer preventative agent resveratrol undergoes metabolism by the cytochrome P450 enzyme CYP1B1 to give a metabolite which has been identified as the known antileukaemic agent piceatannol. The metabolite was identified by high performance liquid chromatography analysis using fluorescence detection and the identity of the metabolite was further confirmed by derivatisation followed by gas chromatography–mass spectrometry studies using authentic piceatannol for comparison. This observation provides a novel explanation for the cancer preventative properties of resveratrol. It demonstrates that a natural dietary cancer preventative agent can be converted to a compound with known anticancer activity by an enzyme that is found in human tumours. Importantly this result gives insight into the functional role of CYP1B1 and provides evidence for the concept that CYP1B1 in tumours may be functioning as a growth suppressor enzyme

From the feud to the permitted development proposals and perspectives for the case “Gesualdo

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Dalla protezione della cultura alla cultura della protezione, ",

Relazione introduttiva al X Corso Intensivo su "La protezione dell'edificato storico in zona sismica attraverso il recupero della "Cultura Sismica Locale". Ravello, Ottobre 200

Un piano autoregolatore: il PRG di Telese Terme in L'innovazione del Piano, acura di G. Cinà

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Historical Buildings Affected by Failures. The Case of the Basilica di Collemaggio in L’Aquila.

Since the deep damages occurred to the European architectural heritage after the Second World War, the conservation theory had to face with a complex issue: the partial or totally missing cultural heritage. Among the application of different solutions, the use of reconstruction of destroyed buildings became a recurrent proposal, adopted in many occasions, from Warsaw Castle to Mostar Bridge. In addition, the buildings hit by earthquakes represent a limit conditions for the application of the common procedures coming from the conservation approach. The recent intervention on the Basilica di Collemaggio, a building deeply damaged after the 2009 L'Aquila earthquake, showed an interesting development of the design choices, based on a multidisciplinary approach to the preservation issue. This restoration work collects the difficulties belonging to the theoretical background met in previous experiences, like the discussion on the early 2000 reconstruction of the Frauenkirche in Dresden or the Cathedral of Noto. Moreover, respect to other cases here presented, the set of interventions characterizing Collemaggio were defined according to multicriteria analyses supported by the different levels of details provided by the digital model of the religious complex