120 research outputs found
Investigator experiences with financial conflicts of interest in clinical trials
- Author
- 42 CFR 50 (f)
- A Flanagin
- AAMC Protecting Patients, Preserving Integrity, Advancing Health
- AAMC Protecting Subjects, Preserving Trust, Promoting Progress II
- An-Wen Chan
- Andrea Gruneir
- AW Chan
- C Laine
- CD De Angelis
- CD Naylor
- D Moher
- David L Streiner
- David Moher
- Department of Health and Human Services
- Department of Health and Human Services
- I Sim
- International Committee of Medical Journal Editors
- International Committee of Medical Journal Editors
- J Rehnquist
- James Maskalyk
- Jennifer Gold
- Joel Lexchin
- John Hoey
- JS Ross
- JS Weissman
- KA Schulman
- KF Schulz
- Lorraine E Ferris
- MA Steinman
- Marleen Van Laethem
- Melanie Sekeres
- MM Mello
- Nathan Taback
- PA Rochon
- Paula A Rochon
- PC Gotzsche
- PC Gotzsche
- S Hopewell
- Sunila R Kalkar
- Wei Wu
- Publication venue
- BioMed Central
- Publication date
- 01/01/2011
- Field of study
<p>Abstract</p> <p>Background</p> <p>Financial conflicts of interest (fCOI) can introduce actions that bias clinical trial results and reduce their objectivity. We obtained information from investigators about adherence to practices that minimize the introduction of such bias in their clinical trials experience.</p> <p>Methods</p> <p>Email survey of clinical trial investigators from Canadian sites to learn about adherence to practices that help maintain research independence across all stages of trial preparation, conduct, and dissemination. The main outcome was the proportion of investigators that reported full adherence to preferred trial practices for all of their trials conducted from 2001-2006, stratified by funding source.</p> <p>Results</p> <p>844 investigators responded (76%) and 732 (66%) provided useful information. Full adherence to preferred clinical trial practices was highest for institutional review of signed contracts and budgets (82% and 75% of investigators respectively). Lower rates of full adherence were reported for the other two practices in the trial preparation stage (avoidance of confidentiality clauses, 12%; trial registration after 2005, 39%). Lower rates of full adherence were reported for 7 practices in the trial conduct (35% to 43%) and dissemination (53% to 64%) stages, particularly in industry funded trials. 269 investigators personally experienced (n = 85) or witnessed (n = 236) a fCOI; over 70% of these situations related to industry trials.</p> <p>Conclusion</p> <p>Full adherence to practices designed to promote the objectivity of research varied across trial stages and was low overall, particularly for industry funded trials.</p
IPOs and the Slow Death of Section 5
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2013
- Field of study
Active Packaging Technologies with an Emphasis on Antimicrobial Packaging and its Applications
- Author
- [CFR] Code of Federal Regulations.
- Abler LA
- Acar JF
- Ahvenainen R
- An DS
- An DS
- Appendini P
- Barnby-Smith FM.
- Begin A
- Chen MC
- Chen MJ
- Cho YW
- Chung SK
- Clark GS.
- Coma V
- Conner DE.
- Cooksey K.
- Davidson PM
- Davidson PM.
- Devlieghere F
- Devlieghere F
- Dillon RJ.
- Dobias J
- Doores S.
- Fallik E
- Farber JM.
- Floros JD
- Fuglsang CC
- Ha JU
- Halek GW
- Han JH
- Han JH
- Han JH.
- Helander IM
- Hong SI
- Hotchkiss JH.
- Huang LJ
- Ishitani T.
- Isshiki K
- Labuza TP
- Lee DS
- Lim LT
- Lis-Balchin M
- Lyver A
- Miltz J
- Natrajan N
- Natrajan N
- Nettles CG
- Nicholson MD.
- Opperman WJ
- Ouattara B
- Ouattara B
- Ouattara B
- Ozdemir M
- Paik JS
- Rico-Pena DC
- Rooney ML.
- Scannell AGM
- Scora KM
- Seiler DAL.
- Shearer AEH
- Shelef LA
- Siragusa GR
- Smilanick JL
- Smith JP
- Smith JP
- Sonneveld K.
- Sudarshan NR
- Teumac FN.
- Thomas P
- Vermeiren L
- Vermeiren L
- Vojdani F
- Vojdani F
- Walker JRL.
- Weng YM
- Weng YM
- Weng YM
- Weng YM
- Weng YM
- Wong DWS
- Xiao C
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
- Author
- Abdel-Aziz AK
- Abdelfatah S
- Abdellatif M
- Abdoli A
- Abel S
- Abeliovich H
- Abildgaard MH
- Abudu YP
- Acevedo-Arozena A
- Adamopoulos IE
- Adeli K
- Adolph TE
- Adornetto A
- Aflaki E
- Agam G
- Agarwal A
- Aggarwal BB
- Agnello M
- Agostinis P
- Agrewala JN
- Agrotis A
- Aguilar PV
- Ahmad ST
- Ahmed ZM
- Ahumada-Castro U
- Aits S
- Aizawa S
- Akkoc Y
- Akoumianaki T
- Akpinar HA
- Al-Abd AM
- Al-Akra L
- Al-Gharaibeh A
- Alaoui-Jamali MA
- Alberti S
- Alcocer-GĂłmez E
- Alessandri C
- Ali M
- Alim Al-Bari MA
- Aliwaini S
- Alizadeh J
- Almacellas E
- Almasan A
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- Altieri DC
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- Alzaharna MM
- Amadio M
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- Zhu B
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- Zhuang H
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- Zientara-Rytter K
- Zimmermann CM
- Ziviani E
- Zoladek T
- Zong W-X
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- Zorzano A
- Zou W
- Zou Z
- Zou Z
- Zuryn S
- Zwerschke W
- Ălvarez ĂMC
- Ăvalos Y
- Ănal G
- ĂstĂŒn S
- ÄoliÄ M
- ÄokiÄ J
- Ćœerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Beyond the threshold: real-time use of evidence in practice
- Author
- A Feldstein
- A Flexner
- A Ozdas
- A Wright
- A Wright
- A Wright
- AC Feldstein
- AH Morris
- AK Jha
- AW Forrey
- AX Garg
- B Chaudhry
- CA Gorman
- CJ McDonald
- CJ McDonald
- CL Sistrom
- CM DesRoches
- CS Dayton
- D Blumenthal
- D Blumenthal
- D Blumenthal
- D Sittig
- Dean F Sittig
- Department of Health and Human Services. 45 CFR Part 170 RIN 0991âAB58. Health Information Technology
- DF Sittig
- DF Sittig
- DF Sittig
- DF Sittig
- DW Bates
- E Ammenwerth
- E Larson
- EA McGlynn
- ES Berner
- ES Berner
- G Hripcsak
- GM Chertow
- H Singh
- H Singh
- H Singh
- H van der Sijs
- I Modak
- Institute of Medicine Committee on Quality of Health Care in America
- JA Osheroff
- James B Jones
- JB Jones
- JC Maro
- JJ Cimino
- JK Iglehart
- JL Schnipper
- Jonathan D Darer
- JS Ash
- K Kawamoto
- KG Shojania
- KG Shojania
- LH Harpole
- LI Solberg
- LT Kohn
- M Berg
- M Butzlaff
- M Mansouri
- MD Cabana
- MM Kuilboer
- P Ramnarayan
- PA Bonis
- PE Mazmanian
- PL Miller
- PR Dexter
- R Mangione-Smith
- RA Miller
- RN Shiffman
- RS Ledley
- S Kim
- S Shea
- SA Abookire
- ST Rosenbloom
- T Turner
- TD Sequist
- Walter F Stewart
- WW Stead
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Leishmania in synanthropic rodents (Rattus rattus): new evidence for the urbanization of Leishmania (Leishmania) amazonensis
- Author
- Akhavan AA
- Alencar JE
- Alexander B
- Alvar J
- Andrade MS
- Ashford RW
- Barbosa PBBM
- Barral A
- Ben-Ismail R
- Bonvicino CR
- BrandĂŁo-Filho SP
- Brilhante AF
- Camara-Coelho LI
- Cardoso RM
- Carvalho BM
- Carvalho BM
- Castro EA
- Catarino CLM
- Cerino DA
- Constantino C
- Costa L
- Cruz CFR
- Cruz MFR
- CĂĄssia-Pires R
- Dantas-Torres F
- Davami MH
- Dean AG
- Di Bella C
- Dias ES
- Dias-Sversutti ADC
- Dorval MEC
- Dorval MEC
- Dorval MEMC
- Dujardin JC
- DĂaz-SĂĄez V
- DâAndrea LAZ
- El Adhami B
- Ferreira EC
- Forattini OP
- Freitas RA
- Gomes AC
- Gramiccia M
- Helhazar M
- Hoffmann AR
- Ibrahim EA
- Lainson R
- Lainson R
- Lara-Silva FO
- Lima BS
- Lima H
- MarassĂĄ AM
- Marcelino AP
- Marlow MA
- Melo SCCS
- Membrive NA
- Membrive NA
- Mendonça PG
- Mimori T
- Mirzaei A
- Mukhtar MM
- Navea-PĂ©rez HM
- NegrĂŁo GN
- Neitzke-Abreu HC
- Oliveira FJA
- Oliveira FS
- Oliveira JPC
- Oliveira TMFS
- Papadogiannakis E
- Pontello Jr R
- Pozio E
- Quaresma PF
- Reis HR
- Richini-Pereira VB
- Roque ALR
- Rotureau B
- Santos DR
- Shaw JJ
- Shender LA
- Silva AM
- Silveira TGV
- Singh N
- Souza AL
- SvobodovĂĄ M
- Szargiki R
- Tanure A
- Telleria J
- Teodoro U
- Teodoro U
- Tolezano JE
- Van der Auwera G
- Van Eys GJJM
- Vladimir I
- Zanet S
- Zulueta AM
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Il dialetto di Matera.
- Author
- Publication venue
- 'Walter de Gruyter GmbH'
- Publication date
- 01/01/1917
- Field of study
Wenn Menschen sich selbst ausschlachten
- Publication venue
- Spiegel-Verlag
- Publication date
- 01/01/2004
- Field of study
Immer weniger Menschen sind zu Organspenden bereit, wĂ€hrend KrankenhĂ€user immer gröĂeren Bedarf melden. Muss der Organhandel freigegeben werden? In SPIEGEL ONLINE plĂ€dieren der Bio-Ethiker Christian Illies und der Medizinprofessor Franz Weber fĂŒr einen anderen Weg
Gatekeepers Failures (and Non-independence) on Parmalat
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2005
- Field of study
Circoncisione e cittadinanza europea (Circumcision and EU citizenship)
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
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