Of, By, and For Which People? Government and Contested Heritage in the American Midwest

Two government-owned and managed heritage sites in Indiana, USA, offer an opportunity to explore the role of governments in adjudicating the competing paradigms of value and contested uses. Strawtown Koteewi is a Hamilton County park and Mounds State Park is part of the Indiana Department of Natural Resources statewide park system. Each site has come under scrutiny in recent years. Strawtown Koteewi is one of the most significant sites in the area for understanding the history of Native peoples. After almost a decade of archaeological excavations, several Native American groups, under the auspices of the Native American Graves Protection and Repatriation Act (NAGPRA), initiated repatriation processes for the recovery of human remains, and some objected to the ongoing archaeological research. At Mounds State Park a coalition of citizens opposed a planned dam project intended to ensure a safe and plentiful water supply and to spur economic development in the area. In each case, the government entities have had to navigate the political landscapes of competing claims about the sites. These case studies expose the fissures between authorized heritage discourse and the paradigms of meaning among the diverse constituencies of the sites, and they highlight the tenuous position of public governance in privileging competing cultural, economic, and social interests. While not unique, the state and county agencies’ positions within these fields of power and their strategic choices reveal some of the barriers and constraints that limit their actions as well as the deep-seated ideologies of policies that perpetuate settler colonial politics in the control and interpretation of indigenous heritage

Interferon-α Improves Phosphoantigen-Induced Vγ9Vδ2 T-Cells Interferon-γ Production during Chronic HCV Infection

In chronic HCV infection, treatment failure and defective host immune response highly demand improved therapy strategies. Vγ9Vδ2 T-cells may inhibit HCV replication in vitro through IFN-γ release after Phosphoantigen (PhAg) stimulation. The aim of our work was to analyze Vγ9Vδ2 T-cell functionality during chronic HCV infection, studying the role of IFN-α on their function capability. IFN-γ production by Vγ9Vδ2 T-cells was analyzed in vitro in 24 HCV-infected patients and 35 healthy donors (HD) after PhAg stimulation with or without IFN-α. The effect of in vivo PhAg/IFN-α administration on plasma IFN-γ levels was analyzed in M. fascicularis monkeys. A quantitative analysis of IFN-γ mRNA level and stability in Vγ9Vδ2 T-cells was also evaluated. During chronic HCV infection, Vγ9Vδ2 T-cells showed an effector/activated phenotype and were significantly impaired in IFN-γ production. Interestingly, IFN-α was able to improve their IFN-γ response to PhAg both in vitro in HD and HCV-infected patients, and in vivo in Macaca fascicularis primates. Finally, IFN-α increased IFN-γ-mRNA transcription and stability in PhAg-activated Vγ9Vδ2 T-cells. Altogether our results show a functional impairment of Vγ9Vδ2 T-cells during chronic HCV infection that can be partially restored by using IFN-α. A study aimed to evaluate the antiviral impact of PhAg/IFN-α combination may provide new insight in designing possible combined strategies to improve HCV infection treatment outcome

Screening for therapeutic trials and treatment indication in clinical practice: MACK-3, a new blood test for the diagnosis of fibrotic NASH

BACKGROUND: The composite histological endpoint comprising nonalcoholic steatohepatitis (NASH) and NAFLD activity score ≥4 and advanced fibrosis (F ≥ 2) ("fibrotic NASH") is becoming an important diagnostic target in NAFLD: it is currently used to select patients for inclusion in phase III therapeutic trials and will ultimately be used to indicate treatment in clinical practice once the new drugs are approved. AIM: To develop a new blood test specifically dedicated for this new diagnostic target of interest. METHODS: Eight Hundred and forty-six biopsy-proven NAFLD patients from three centres (Angers, Nice, Antwerp) were randomised into derivation and validation sets. RESULTS: The blood fibrosis tests BARD, NFS and FIB4 had poor accuracy for fibrotic NASH with respective AUROC: 0.566 ± 0.023, 0.654 ± 0.023, 0.732 ± 0.021. In the derivation set, fibrotic NASH was independently predicted by AST, HOMA and CK18; all three were combined in the new blood test MACK-3 (hoMa, Ast, CK18) for which 90% sensitivity and 95% specificity cut-offs were calculated. In the validation set, MACK-3 had a significantly higher AUROC (0.847 ± 0.030, P ≤ 0.002) than blood fibrosis tests. Using liver biopsy in the grey zone between the two cut-offs (36.0% of the patients), MACK-3 provided excellent accuracy for the diagnosis of fibrotic NASH with 93.3% well-classified patients, sensitivity: 90.0%, specificity: 94.2%, positive predictive value: 81.8% and negative predictive value: 97.0%. CONCLUSION: The new blood test MACK-3 accurately diagnoses fibrotic NASH. This new test will facilitate patient screening and inclusion in NAFLD therapeutic trials and will enable the identification of patients who will benefit from the treatments once approved

Multi scale analysis by acoustic emission of damage mechanisms in natural fibre woven fabrics/epoxy composites.

This paper proposes to develop an experimental program to characterize the type and the development of damage in composite with complex microstructure. A multi-scale analysis by acoustic emission has been developed and applied to hemp fibre woven fabrics/epoxy composite. The experimental program consists of tensile tests performed on single yarn, neat epoxy resin and composite materials to identify their AE amplitude signatures. A statistical analysis of AE amplitude signals has been realised and correlated with microscopic observations. Results have enabled to identify three types of damage in composites and their associated AE amplitudes: matrix cracking, interfacial debonding and reinforcement damage and fracture. Tracking of these damage mechanisms in hemp/epoxy composites has been performed to show the process of damage development in natural fibre reinforced composites

Analyse multi-échelle du comportement mécanique de composites tissés à fibres de chanvre. Comparaison avec le lin et le verre

Ce travail propose une analyse multi-échelle de la structure et du comportement mécanique de composites chanvre/époxy à renforts tissus. Une comparaison systématique est effectuée avec des composites tissés verre/époxy et lin/époxy. Les structures des fils de verre, de lin et de chanvre ont été analysées. Des analyses statistiques ont été utilisées pour étudier leur comportement mécanique. Un modèle analytique en trois étapes permettant d’estimer les propriétés mécaniques de ces matériaux a été mis en place en partant des propriétés des constituants élémentaires de la fibre : les fibrilles de cellulose, la lignine et l’hémicellulose. La variabilité des fibres naturelles a été intégrée à ce modèle en utilisant les résultats expérimentaux. Les résultats obtenus avec ce modèle permettent d’obtenir une estimation des caractéristiques mécaniques des composites chanvre/époxy à renfort tissu

Farm diversity, classification schemes and multifunctionality

Diversity is not only intrinsic to agriculture; it can be considered also as one of its main assets as it provides a wide range of responses that can help to face uncertain futures. The ongoing encounter between changing spatial and temporal frameworks and a set of diverse farming strategies is leading to the emergence of an ongoing flow of development models that could materialize in a wide range of farming practices, contrasting enterprise models, changing relations between rural households and agricultural holdings, and differentiated patterns that link farming and farming families to the wider context in which they are embedded. The many-sided diversity encountered in agriculture is not only the outcome of the agency and polyvalence of the actors involved; their agency and polyvalence are in turn inspired and strengthened by the material and symbolic diversity, which contributes to a further unfolding of diversity. A proper understanding of the range, dimensions, significance and causes of diversity has been, over the centuries, a main concern¿first for what is now known as classical agronomy, and later on in agrarian sciences. Yet the classification schemes, developed and used for such an understanding, have increasingly become an Achilles heel as each of them relies on specific assumptions that will bring out particular features of the overall farm diversity and will result in different perspectives of what agriculture is and how it fits into societal projects. Consequently, they are at the core of many debates and struggles, not only within agrarian sciences but increasingly on a wider societal level. The growing recognition of multifunctionality in agriculture, especially in the context of the changing EU policy, strengthens the relevance and importance of this debate. In this new context, we discuss advantages and limits of different classification principles by comparing two methodologies which have been extensively used in France and the Netherland