Improving the concrete sections after removing intermediate support of RC continuous non-prismatic beam

An experimental study was conducted to investigate the performance of the 2-span continuous reinforced concrete beams of different section depth after removing the middle support by adding steel fibers or steel plates. The beams were loaded monotonically with two-point loads. One continuous beam and six simply supported beams of non-prismatic section were tested using two different content of steel fibers and three different locations of steel plates welded to the reinforcement. The test results reveal that using inclined steel plates at the region of changing of cross section thickness at the middle support increase the load capacity of the beam significantly up to 75% of the continuous beam capacity, and a significant warning before failure is shown. Adding steel fibers to the concrete has less influence on the capacity of the beam. The failure mode of the beams with no middle support is the same, but with different values of deflection. The inclined steel plate again is the most effective way to decrease the deflection because of the increased stiffness of the cross section. To achieve the same capacity of the continuous beam after removing the middle support, it is recommended to use horizontal steel plates welded to the reinforcement at the region of the middle support extended within one fourth the length of each span of different thickness to avoid the stress concentration resulted from the large deflection at that region

Prevalence and gender distribution of the metabolic syndrome

<p>Abstract</p> <p>Background</p> <p>The Metabolic syndrome (MetS) is a cardiovascular risk factor of public health significance and of recent has become a topical issue. The prevalence of diabetes mellitus (DM) is on the increase and with this scenario, a possible increase in burden of DM which may be largely attributed to cardiovascular complications is expected. The objective of this report is to determine the prevalence of the MetS and compare gender characteristics in subjects with type 2 DM.</p> <p>Methods</p> <p>Subjects with type 2 DM were recruited from an urban hospital for the study. Clinical data was obtained by interviewing the patients and referring to their Case folders. The anthropometric indices and blood pressure measurements were documented. Laboratory parameters analysed for included total cholesterol, high density and low density cholesterol, triglyceride and glycosylated haemoglobin. Statistical analysis included usage of Student's t test and chi square.</p> <p>Results</p> <p>963 patients with type 2 DM aged between 35-85 years were recruited for the study. The main outcome measures included the prevalence of the metabolic syndrome and the gender differences of its components. The prevalence of the metabolic syndrome was 86%. The frequency of occurrence of the MetS was similar for men (83%) and women (86%) and increased with age in both sexes. The prevalence of MetS increased from 11% among participants aged 20 through 29 years to 89% in participants aged 70 through 79. In our patients with DM, the commonest occurring and least detected MetS defining parameters are central obesity and elevated triglyceride levels respectively. The components of the MetS that differed significantly in both sexes was HDL-C. The combination of the components of the MetS were comparable in both genders and 5.8% of the subjects with the MetS had all components of the MetS.</p> <p>Conclusion</p> <p>The prevalence of the MetS in type 2DM is high in both genders and increases with age thus posing a potential high cardiovascular risk in this group of patients. The modifiable risk factors for the MetS should be a focus point in the management of subjects with type 2 DM,</p

Prevalence of the metabolic syndrome in patients with diabetes mellitus

Background Metabolic syndrome (MetS) is a vascular risk factor with prevalence in the general population of 1725%. Aim To determine the prevalence of MetS in patients with diabetes mellitus (DM). Methods A total of 200 patients [18% type 1 (T1DM), 82% type 2 (T2DM)] attending for annual review were studied. Standard blood tests were requested. Blood pressure and waist circumference were measured. Adult Treatment Panel III (ATP III) criteria for diagnosis of MetS were applied. Results A total of 122 (61%) patients had MetS. More patients with T2DM (69.5%) than TIDM (22.2%) had MetS. Despite treatment of DM (100%), hypertension (69.5%) and dyslipidaemia (48.3%), 114 patients (57%) still met the criteria for MetS at time of study. © Royal Academy of Medicine in Ireland 2009

Haplotype association of calpain 10 gene variants with type 2 diabetes mellitus in an Irish sample

Background: Calpain 10 (CAPN10) gene may contribute to the pathogenesis of type 2 diabetes mellitus (T2DM). Aim: To examine the contribution of four CAPN10 gene variants to T2DM risk in an Irish sample. Methods: Genotyping of marker 19 insertion-deletion (ins/del) and three CAPN10 variants, rs3792267, rs3749166 and rs5030952 at the CAPN10 gene was performed in 236 T2DM subjects and 120 controls. Allelic, genotypic and haplotype comparisons were conducted between the groups. Results: In the examined markers, no significant differences were observed although the deletion/deletion allele tended to be more common in T2DM subjects (χ = 3.2, P = 0.07). A significant overrepresentation of a haplotype comprising (rs3792267), (19) and rs3749166 (χ = 5.3, P = 0.021) was seen in T2DM subjects. Two protective haplotypes were detected: (G-ins-G) of (rs3792267), (19) and rs3749166 (χ = 6.7, P = 0.009) and (ins-G-C) of (19), (rs3749166) and rs5030952 (χ = 8.5, P = 0.003). Conclusions: CAPN10 gene variants may affect T2DM susceptibility in the Irish population