1,039 research outputs found
Fused Imidazopyrazoles: Synthetic Strategies and Medicinal Applications
The current review summarizes the known synthetic routes of fused imidazopyrazoles. This review is classified into two main categories based on the type of annulations, for example, annulation of the imidazole ring onto a pyrazole scaffold or annulation of the pyrazole ring onto an imidazole scaffold. Some medicinal applications of imidazopyrazoles are mentioned
5-(4-Fluorophenyl)-3-[5-methyl-1-(4-methylphenyl)-1H-1,2,3-triazol-4-yl]-4,5-dihydro-1H-pyrazole-1-carbothioamide
In the title compound, C20H19FN6S, the pyrazole ring has an envelope conformation, with the methine C atom being the flap atom. The dihedral angle between the least-squares plane through the pyrazole and triazole rings is 7.59 (9)°, and the triazole and attached benzene ring form a dihedral angle of 74.79 (9)°. The thiourea group is coplanar with the pyrazole ring [N—N—C—S torsion angle = −179.93 (11)°], which enables the formation of an intramolecular N—H⋯N hydrogen bond. In the crystal, inversion-related molecules associate via N—H⋯S hydrogen bonds and eight-membered {⋯HNCS}2 synthons feature in the crystal packing. These synthons are connected into supramolecular chains along the a axis via N—H⋯F hydrogen bonds, and the chains are consolidated into layers in the ab plane via C—H⋯S and C—H⋯F contacts
4-{1-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]-5-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-3-yl}-5-methyl-1-(4-methylphenyl)-1H-1,2,3-triazole
In the title compound, C28H22BrFN6S, the central pyrazole ring has an envelope conformation, with the methine C atom being the flap atom. The dihedral angles between the least-squares plane through this ring and the adjacent thiazole [18.81 (15)°] and triazole [1.83 (16)°] rings indicate a twist in the molecule. A further twist is evident by the dihedral angle of 64.48 (16)° between the triazole ring and the attached benzene ring. In the crystal, C—H⋯N, C—H⋯F, C—H⋯π and π–π interactions [occurring between the thiazole and triazole rings, centroid–centroid distance = 3.571 (2) Å] link molecules into a three-dimensional architecture. The sample studied was a non-merohedral twin; the minor twin component refined to 47.16 (7)%
Thin film composite hollow fibre forward osmosis membrane module for the desalination of brackish groundwater for fertigation
© 2015 Elsevier B.V. The performance of recently developed polyamide thin film composite hollow fibre forward osmosis (HFFO) membrane module was assessed for the desalination of brackish groundwater for fertigation. Four different fertilisers were used as draw solution (DS) with real BGW from the Murray-Darling Basin in Australia. Membrane charge and its electrostatic interactions with ions played a significant role in the performance of the HFFO module using fertiliser as DS. Negatively charged polyamide layer promotes sorption of multivalent cations such as Ca2+ enhancing ion flux and membrane scaling. Inorganic scaling occurred both on active layer and inside the support layer depending on the types of fertiliser DS used resulting in severe flux decline and this study therefore underscores the importance of selecting suitable fertilisers for the fertiliser drawn forward osmosis (FDFO) process. Water flux under active layer DS membrane orientation was about twice as high as the other orientation indicating the need to further optimise the membrane support structure formation. Water flux slightly improved at higher crossflow rates due to enhanced mass transfer on the fibre lumen side. At 45% packing density, HFFO could have three times more membrane area and four times more volumetric flux output for an equivalent 8040 cellulose triacetate flat-sheet FO membrane module
Crystal structure of 2-((3-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-1-phenyl-1H-pyrazol-4-yl)methylene)-1H-indene-1,3(2H)-dione, C28H19N5O2
Abstract
C28H19N5O2, monoclinic, Cc (no. 9), a = 13.9896(9) Å, b = 21.9561(14) Å, c = 7.1643(5) Å, β = 91.782(6)°, V = 2199.5(3) Å3, Z = 4, R
gt(F) = 0.0632, wR
ref(F
2) = 0.1727, T = 150(2) K.</jats:p
Crystal structure of (E)-5-((4-chlorophenyl)diazenyl)-2-(5-(4-fluorophenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)-4-methylthiazole, C23H17ClFN5S2
Abstract
C23H17ClFN5S2, monoclinic, P21/c (no. 14), a = 20.9691(12) Å, b = 11.5316(6) Å, c = 9.2546(4) Å, β = 95.484(4)°, V = 2227.6(2) Å3, Z = 4, R
gt(F) = 0.0468, wR
ref(F
2) = 0.1126, T = 296 K.</jats:p
Crystal structure of 1-phenyl-N′-(1-phenyl-5-(thiophen-2-yl)-1H-pyrazole-3-carbonyl)-5-(thiophen-2-yl)-1H-pyrazole-3-carbohydrazide, C28H20N6O2S2
C28H20N6O2S2, triclinic, P1̅ (no. 2), a = 10.6738(6) Å, b = 11.7869(7) Å, c = 12.5381(7) Å, α = 112.842(6)°, β = 91.963(4)°, γ = 116.129(6)°, V = 1264.38(15) Å3, Z = 2, Rgt(F) = 0.0523, wRref(F2) = 0.1390, T = 296(2) K
Crystal structure of 4-(benzofuran-2-yl)-2-(3-(4-fluorophenyl)-3,3a,4,5-tetrahydro-2H-benzo[g]indazol-2-yl)thiazole, C28H20FN3OS
Abstract
C28H20FN3OS, triclinic, P1̅ (no. 2), a = 9.5719(5) Å, b = 10.7499(6) Å, c = 10.9238(5) Å, α = 95.470(4)°, β = 102.133(4)°, γ = 97.962(4)°, V = 1079.30(10) Å3, R
gt(F) = 0.0482, wR
ref(F
2) = 0.1143, T = 150(2) K.</jats:p
Temperature and Frequency Dependence of the Electrical Properties of Metal Alginate Complexes
Crystal structure of (E)-3-(3-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-1-phenyl-1H-pyrazol-4-yl)-1-phenylprop-2-en-1-one, C27H21N5O
C27H21N5O, triclinic, P1̄ (no. 2), a = 8.1464(7) Å, b = 10.3861(8) Å, c = 13.2507(9) Å, α = 84.898(6)°, β = 89.413(6)°, γ = 80.351(7)°, V = 1100.88(15) Å3, Z = 2, Rgt(F) = 0.0648, wRref(F2) = 0.1726, T = 296(2) K
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