Influence of the calcium concentration in the presence of organic phosphorus on the physicochemical compatibility and stability of all-in-one admixtures for neonatal use

<p>Abstract</p> <p>Background</p> <p>Preterm infants need high amounts of calcium and phosphorus for bone mineralization, which is difficult to obtain with parenteral feeding due to the low solubility of these salts. The objective of this study was to evaluate the physicochemical compatibility of high concentrations of calcium associated with organic phosphate and its influence on the stability of AIO admixtures for neonatal use.</p> <p>Methods</p> <p>Three TPN admixture formulas were prepared in multilayered bags. The calcium content of the admixtures was adjusted to 0, 46.5 or 93 mg/100 ml in the presence of a fixed organic phosphate concentration as well as lipids, amino acids, inorganic salts, glucose, vitamins and oligoelements at pH 5.5. Each admixture was stored at 4°C, 25°C or 37°C and evaluated over a period of 7 days. The physicochemical stability parameters evaluated were visual aspect, pH, sterility, osmolality, peroxide formation, precipitation, and the size of lipid globules.</p> <p>Results</p> <p>Color alterations occurred from the first day on, and reversible lipid film formation from the third day of study for the admixtures stored at 25°C and 37°C. According to the parameters evaluated, the admixtures were stable at 4°C; and none of them presented precipitated particles due to calcium/phosphate incompatibility or lipid globules larger than 5 μm, which is the main parameter currently used to evaluate lipid emulsion stability. The admixtures maintained low peroxide levels and osmolarity was appropriate for parenteral administration.</p> <p>Conclusion</p> <p>The total calcium and calcium/phosphorus ratios studied appeared not to influence the physicochemical compatibility and stability of AIO admixtures.</p

Erratum to: Measurement of ϒ production in pp collisions at s√ = 13 TeV

</p

Measurement of the Charm-Mixing Parameter yCP

A measurement of the charm-mixing parameter y_{CP} using D^{0}→K^{+}K^{-}, D^{0}→π^{+}π^{-}, and D^{0}→K^{-}π^{+} decays is reported. The D^{0} mesons are required to originate from semimuonic decays of B^{-} and B[over ¯]^{0} mesons. These decays are partially reconstructed in a data set of proton-proton collisions at center-of-mass energies of 7 and 8 TeV collected with the LHCb experiment and corresponding to an integrated luminosity of 3  fb^{-1}. The y_{CP} parameter is measured to be (0.57±0.13(stat)±0.09(syst))%, in agreement with, and as precise as, the current world-average value

Measurement of b hadron fractions in 13 TeV pp collisions

The production fractions of ¯ B 0 s and Λ 0 b hadrons, normalized to the sum of B − and ¯ B 0 fractions, are measured in 13 TeV p p collisions using data collected by the LHCb experiment, corresponding to an integrated luminosity of 1.67     fb − 1 . These ratios, averaged over the b hadron transverse momenta from 4 to 25 GeV and pseudorapidity from 2 to 5, are 0.122 ± 0.006 for ¯ B 0 s , and 0.259 ± 0.018 for Λ 0 b , where the uncertainties arise from both statistical and systematic sources. The Λ 0 b ratio depends strongly on transverse momentum, while the ¯ B 0 s ratio shows a mild dependence. Neither ratio shows variations with pseudorapidity. The measurements are made using semileptonic decays to minimize theoretical uncertainties. In addition, the ratio of D + to D 0 mesons produced in the sum of ¯ B 0 and B − semileptonic decays is determined as 0.359 ± 0.006 ± 0.009 , where the uncertainties are statistical and systematic

Study of the B0→ρ(770)0K∗(892)0B^0\to \rho(770)^0 K^*(892)^0 decay with an amplitude analysis of B0→(π+π−)(K+π−)B^0\to (\pi^+\pi^-) (K^+\pi^-) decays

International audienceAn amplitude analysis of B$^{0}$ → (π$^{+}$π$^{−}$)(K$^{+}$π$^{−}$) decays is performed in the two-body invariant mass regions 300 < m(π$^{+}$π$^{−}$) < 1100 MeV/c$^{2}$, accounting for the ρ$^{0}$, ω, f$_{0}$(500), f$_{0}$(980) and f$_{0}$(1370) resonances, and 750 < m(K$^{+}$π$^{−}$) < 1200 MeV/c$^{2}$, which is dominated by the K$^{*}$(892)$^{0}$ meson. The analysis uses 3 fb$^{−1}$ of proton-proton collision data collected by the LHCb experiment at centre-of-mass energies of 7 and 8 TeV. The CP averages and asymmetries are measured for the magnitudes and phase differences of the con- tributing amplitudes. The CP-averaged longitudinal polarisation fractions of the vector-vector modes are found to be ${\tilde{f}}_{\rho {K}^{*}}^0$ = 0.164 ± 0.015 ± 0.022 and ${\tilde{f}}_{\omega {K}^{*}}^0$ = 0.68 ± 0.17 ± 0.16, and their CP asymmetries, ${\mathcal{A}}_{\rho {K}^{*}}^0$ = −0.62 ± 0.09 ± 0.09 and ${\mathcal{A}}_{\omega {K}^{*}}^0$ = −0.13 ± 0.27 ± 0.13, where the first uncertainty is statistical and the second systematic

Measurement of the branching fraction and CP asymmetry in B plus . J/.. plus decays

The branching fraction and direct $C\!P$ asymmetry of the decay $B^{+}\rightarrow J/\psi \rho^{+}$ are measured using proton-proton collision data collected with the LHCb detector at centre-of-mass energies of 7 and 8 TeV, corresponding to a total integrated luminosity of 3\mbox{fb}^{-1}. The following results are obtained: \begin{align} \mathcal{B}(B^{+}\rightarrow J/\psi \rho^{+}) &= (3.81 ^{+0.25}_{-0.24} \pm 0.35) \times 10^{-5}, \nonumber \\ \mathcal{A}^{C\!P} (B^{+}\rightarrow J/\psi \rho^{+}) &= -0.045^{+0.056}_{-0.057} \pm 0.008, \nonumber \end{align} where the first uncertainties are statistical and the second systematic. Both measurements are the most precise to date.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2018-036.htm

Search for CPCP violation through an amplitude analysis of D0→K+K−π+π−D^0 \to K^+ K^- \pi^+ \pi^- decays

International audienceA search for CP violation in the Cabibbo-suppressed D$^{0}$ → K$^{+}$K$^{−}$π$^{+}$π$^{−}$ decay mode is performed using an amplitude analysis. The measurement uses a sample of pp collisions recorded by the LHCb experiment during 2011 and 2012, corresponding to an integrated luminosity of 3.0 fb$^{−1}$. The D$^{0}$ mesons are reconstructed from semileptonic b-hadron decays into D$^{0}$μ$^{−}$X final states. The selected sample contains more than 160 000 signal decays, allowing the most precise amplitude modelling of this D$^{0}$ decay to date. The obtained amplitude model is used to perform the search for CP violation. The result is compatible with CP symmetry, with a sensitivity ranging from 1% to 15% depending on the amplitude considered

Search for CP Violation in D-s(+) -> K-S(0)pi(+), D+ -> (KSK+)-K-0, and D+ -> phi pi(+) Decays

A search for charge-parity ($CP$) violation in Cabibbo-suppressed $D_s^+\to K_S^0 \pi^+$, $D^+\to K_S^0 K^+$ and $D^+\to \phi \pi^+$ decays is reported using proton-proton collision data, corresponding to an integrated luminosity of 3.8 fb$^{-1}$, collected at a center-of-mass energy of 13 TeV with the LHCb detector. High-yield samples of kinematically and topologically similar Cabibbo-favored $D_{(s)}^+$ decays are analyzed to subtract nuisance asymmetries due to production and detection effects, including those induced by $CP$ violation in the neutral kaon system. The results are \begin{align*} \mathcal{A}_{CP}(D_s^+\to K_S^0 \pi^+) &=\left(\phantom{-}1.3\phantom{0}\pm1.9\phantom{0}\pm0.5\phantom{0}\right)\times10^{-3},\\ \mathcal{A}_{CP}(D^+\to K_S^0 K^+) &=\left(-0.09\pm0.65\pm0.48\right)\times10^{-3},\\ \mathcal{A}_{CP}(D^+\to \phi \pi^+) &=\left(\phantom{-}0.05\pm0.42\pm0.29\right)\times10^{-3}, \end{align*} where the first uncertainties are statistical and the second systematic. They are the most precise measurements of these quantities to date, and are consistent with $CP$ symmetry.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2019-002.htm

Search for beautiful tetraquarks in the <i>ϒ</i>(1<i>S</i>)μ⁺μ⁻ invariant-mass spectrum

International audienceThe ϒ(1S)μ$^{+}$μ$^{−}$ invariant-mass distribution is investigated for a possible exotic meson state composed of two b quarks and two $\overline{b}$ quarks, ${X}_{b\overline{b}b\overline{b}}$ . The analysis is based on a data sample of pp collisions recorded with the LHCb detector at centre-of-mass energies $\sqrt{s}=7$ , 8 and 13 TeV, corresponding to an integrated luminosity of 6.3 fb$^{−1}$. No significant excess is found, and upper limits are set on the product of the production cross-section and the branching fraction as functions of the mass of the ${X}_{b\overline{b}b\overline{b}}$ state. The limits are set in the fiducial volume where all muons have pseudorapidity in the range [2.0, 5.0], and the ${X}_{b\overline{b}b\overline{b}}$ state has rapidity in the range [2.0, 4.5] and transverse momentum less than 15 GeV/c