16 research outputs found

    Staged Self-Assembly: Nanomanufacture of Arbitrary Shapes with O(1) Glues

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    We introduce staged self-assembly of Wang tiles, where tiles can be added dynamically in sequence and where intermediate constructions can be stored for later mixing. This model and its various constraints and performance measures are motivated by a practical nanofabrication scenario through protein-based bioengineering. Staging allows us to break through the traditional lower bounds in tile self-assembly by encoding the shape in the staging algorithm instead of the tiles. All of our results are based on the practical assumption that only a constant number of glues, and thus only a constant number of tiles, can be engineered. Under this assumption, traditional tile self-assembly cannot even manufacture an n×n square; in contrast, we show how staged assembly in theory enables manufacture of arbitrary shapes in a variety of precise formulations of the model.

    An Experimental Study of Old and New Depth Measures

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    Data depth is a statistical analysis method that assigns a numeric value to a point based on its centrality relative to a data set. Examples include the half-space depth (also known as Tukey depth), convex-hull peeling depth and L1 depth. Data depth has significant potential as a data analysis tool. The lack of efficient computational tools for depth based analysis of large high-dimensional data sets, however, prevents it from being in widespread use. We provide an experimental evaluation of several existing depth measures on different types of data sets, recognize problems with the existing measures and suggest modifications. Specifically, we show how the L1 depth contours are not indicative of shape and suggest a PCA-based scaling that handles this problem; we demonstrate how most existing depth measures are unable to cope with multimodal data sets and how the newly suggested proximity graph depth addresses this issue; and we explore how depth measures perform when the underlying distribution is not elliptic. Our experimental tool is of independent interest: it is an interactive software tool for the generation of data sets and visualization of the performance of multiple depth measures. The tool uses a hierarchical render-pipeline to allow for diverse data sets and fine control of the visual result. With this tool, new ideas in the field of data depth can be evaluated visually and quickly, allowing researchers to assess and adjust current depth functions
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