On the stability of 2D dipolar Bose-Einstein condensates

We study the existence of energy minimizers for a Bose-Einstein condensate with dipole-dipole interactions, tightly confined to a plane. The problem is critical in that the kinetic energy and the (partially attractive) interaction energy behave the same under mass-preserving scalings of the wave-function. We obtain a sharp criterion for the existence of ground states, involving the optimal constant of a certain generalized Gagliardo-Nirenberg inequality

Regards disciplinaires croisés sur les paysages ordinaires de proximité : un enjeu pour enrichir le lien des élèves au territoire où ils habitent

Habiter est une relation entre un individu ou un groupe social et l’espace dans lequel il inscrit ses pratiques quotidiennes. Cet espace correspond à un ensemble de lieux en réseaux qui peut être vu dans sa matérialité, mais aussi dans ses dimensions symboliques qui permettent de lui donner un sens et d’en construire la représentation que chacun s’en fait (Cailly, 2008). Dans ce processus qui associe étroitement réalité visible et dimension idéale, l’apparence du territoire a une importance c..

On the stability of 2D dipolar Bose-Einstein condensates

International audienceWe study the existence of energy minimizers for a Bose-Einstein condensate with dipole-dipole interactions, tightly confined to a plane. The problem is critical in that the kinetic energy and the (partially attractive) interaction energy behave the same under mass-preserving scalings of the wave-function. We obtain a sharp criterion for the existence of ground states, involving the optimal constant of a certain generalized Gagliardo-Nirenberg inequality

Dossier : Activités pastorales et dynamiques territoriales: Quelles articulations ? Quelles synergies ?

National audienc

New tricarbonylrhenium(I) complexes : from structural study to a potential therapeutic radiopharmaceutical to target hepatocellular carcinoma metastases

International audienc

Overview of Radiolabeled Somatostatin Analogs for Cancer Imaging and Therapy

International audienceIdentified in 1973, somatostatin (SST) is a cyclic hormone peptide with a short biological half-life. Somatostatin receptors (SSTRs) are widely expressed in the whole body, with five subtypes described. The interaction between SST and its receptors leads to the internalization of the ligand-receptor complex and triggers different cellular signaling pathways. Interestingly, the expression of SSTRs is significantly enhanced in many solid tumors, especially gastro-entero-pancreatic neuroendocrine tumors (GEP-NET). Thus, somatostatin analogs (SSAs) have been developed to improve the stability of the endogenous ligand and so extend its half-life. Radiolabeled analogs have been developed with several radioelements such as indium-111, technetium-99 m, and recently gallium-68, fluorine-18, and copper-64, to visualize the distribution of receptor overexpression in tumors. Internal metabolic radiotherapy is also used as a therapeutic strategy (e.g., using yttrium-90, lutetium-177, and actinium-225). With some radiopharmaceuticals now used in clinical practice, somatostatin analogs developed for imaging and therapy are an example of the concept of personalized medicine with a theranostic approach. Here, we review the development of these analogs, from the well-established and authorized ones to the most recently developed radiotracers, which have better pharmacokinetic properties and demonstrate increased efficacy and safety, as well as the search for new clinical indications

Design, Synthesis, and Reactivity of Multidentate Ligands with Rhenium(I) and Rhenium(V) Cores

International audienc

Mutagenesis of both prophenoloxidases in the fall armyworm induces major defects in metamorphosis

International audienceUpon infection, the phenoloxidase system in arthropods is rapidly mobilized and constitutes a major defense system against invaders. The activation of the key enzymes prophenoloxidase (PPO) and their action in immunity through melanization and encapsulation of foreign bodies in hemolymph has been described in many insects. On the other hand, little is known about PPOs involvement in other essential functions related to insect development. In this paper, we investigated the function of the two PPOs of the crop pest, Spodoptera frugiperda (PPO1 and PPO2). We show that PPOs are mainly expressed in hemocytes with the PPO2 expressed at higher levels than the PPO1. In addition, these two genes are expressed in the same tissue and at the same stages of insect development. Through the generation of loss-of-function mutants by CRISPR/Cas9 method, we show that the presence of PPOs is essential for the normal development of the pupa and the survival of the insect

Advances in the chemistry of astatine and implications for the development of radiopharmaceuticals

International audienc