729 research outputs found
Preheating and Affleck-Dine leptogenesis after thermal inflation
Previously, we proposed a model of low energy Affleck-Dine leptogenesis in
the context of thermal inflation. The lepton asymmetry is generated at the end
of thermal inflation, which occurs at a relatively low energy scale with the
Hubble parameter somewhere in the range 1 \keV \lesssim H \lesssim 1 \MeV.
Thus Hubble damping will be ineffective in bringing the Affleck-Dine field into
the lepton conserving region near the origin, leaving the possibility that the
lepton number could be washed out. Previously, we suggested that preheating
could damp the amplitude of the Affleck-Dine field allowing conservation of the
lepton number. In this paper, we demonstrate numerically that preheating does
efficiently damp the amplitude of the Affleck-Dine field and that the lepton
number is conserved as the result. In addition to demonstrating a crucial
aspect of our model, it also opens the more general possibility of low energy
Affleck-Dine baryogenesis.Comment: 38 pages, 17 figure
The Millennium Galaxy Catalogue: morphological classification and bimodality in the colour-concentration plane
Using 10 095 galaxies (B < 20 mag) from the Millennium Galaxy Catalogue, we
derive B-band luminosity distributions and selected bivariate brightness
distributions for the galaxy population. All subdivisions extract highly
correlated sub-sets of the galaxy population which consistently point towards
two overlapping distributions. A clear bimodality in the observed distribution
is seen in both the rest-(u-r) colour and log(n) distributions. The rest-(u-r)
colour bimodality becomes more pronounced when using the core colour as opposed
to global colour. The two populations are extremely well separated in the
colour-log(n) plane. Using our sample of 3 314 (B < 19 mag) eyeball classified
galaxies, we show that the bulge-dominated, early-type galaxies populate one
peak and the bulge-less, late-type galaxies occupy the second. The early- and
mid-type spirals sprawl across and between the peaks. This constitutes
extremely strong evidence that the fundamental way to divide the luminous
galaxy population is into bulges and discs and that the galaxy bimodality
reflects the two component nature of galaxies and not two distinct galaxy
classes. We argue that these two-components require two independent formation
mechanisms/processes and advocate early bulge formation through initial
collapse and ongoing disc formation through splashback, infall and
merging/accretion. We calculate the B-band luminosity-densities and
stellar-mass densities within each subdivision and estimate that the z ~ 0
stellar mass content in spheroids, bulges and discs is 35 +/- 2 per cent, 18
+/- 7 and 47 +/- 7 per cent respectively. [Abridged]Comment: Accepted for publication in MNRAS, 23 pages, 17 figures. Comments
welcome. MGC website is at: http://www.eso.org/~jliske/mgc
Second Order General Slow-Roll Power Spectrum
Recent combined results from the Wilkinson Microwave Anisotropy Probe (WMAP)
and Sloan Digital Sky Survey (SDSS) provide a remarkable set of data which
requires more accurate and general investigation. Here we derive formulae for
the power spectrum P(k) of the density perturbations produced during inflation
in the general slow-roll approximation with second order corrections. Also,
using the result, we derive the power spectrum in the standard slow-roll
picture with previously unknown third order corrections.Comment: 11 pages, 1 figure ; A typo in Eq. (38) is fixed ; References
expanded and a note adde
Simulating the WFIRST coronagraph Integral Field Spectrograph
A primary goal of direct imaging techniques is to spectrally characterize the
atmospheres of planets around other stars at extremely high contrast levels. To
achieve this goal, coronagraphic instruments have favored integral field
spectrographs (IFS) as the science cameras to disperse the entire search area
at once and obtain spectra at each location, since the planet position is not
known a priori. These spectrographs are useful against confusion from speckles
and background objects, and can also help in the speckle subtraction and
wavefront control stages of the coronagraphic observation. We present a
software package, the Coronagraph and Rapid Imaging Spectrograph in Python
(crispy) to simulate the IFS of the WFIRST Coronagraph Instrument (CGI). The
software propagates input science cubes using spatially and spectrally resolved
coronagraphic focal plane cubes, transforms them into IFS detector maps and
ultimately reconstructs the spatio-spectral input scene as a 3D datacube.
Simulated IFS cubes can be used to test data extraction techniques, refine
sensitivity analyses and carry out design trade studies of the flight CGI-IFS
instrument. crispy is a publicly available Python package and can be adapted to
other IFS designs.Comment: 15 page
The causal structure of dynamical charged black holes
We study the causal structure of dynamical charged black holes, with a
sufficient number of massless fields, using numerical simulations. Neglecting
Hawking radiation, the inner horizon is a null Cauchy horizon and a curvature
singularity due to mass inflation. When we include Hawking radiation, the inner
horizon becomes space-like and is separated from the Cauchy horizon, which is
parallel to the out-going null direction. Since a charged black hole must
eventually transit to a neutral black hole, we studied the neutralization of
the black hole and observed that the inner horizon evolves into a space-like
singularity, generating a Cauchy horizon which is parallel to the in-going null
direction. Since the mass function is finite around the inner horizon, the
inner horizon is regular and penetrable in a general relativistic sense.
However, since the curvature functions become trans-Planckian, we cannot
saymore about the region beyond the inner horizon, and it is natural to say
that there is a 'physical' space-like singularity. However, if we assume an
exponentially large number of massless scalar fields, our results can be
extended beyond the inner horizon. In this case, strong cosmic censorship and
black hole complementarity can be violated.Comment: 23 pages, 23 figure
Activation of an Endogenous Retrovirus-Associated Long Non-Coding RNA in Human Adenocarcinoma
Background
Long non-coding RNAs (lncRNAs) are emerging as molecules that significantly impact many cellular processes and have been associated with almost every human cancer. Compared to protein-coding genes, lncRNA genes are often associated with transposable elements, particularly with endogenous retroviral elements (ERVs). ERVs can have potentially deleterious effects on genome structure and function, so these elements are typically silenced in normal somatic tissues, albeit with varying efficiency. The aberrant regulation of ERVs associated with lncRNAs (ERV-lncRNAs), coupled with the diverse range of lncRNA functions, creates significant potential for ERV-lncRNAs to impact cancer biology.
Methods
We used RNA-seq analysis to identify and profile the expression of a novel lncRNA in six large cohorts, including over 7,500 samples from The Cancer Genome Atlas (TCGA).
Results
We identified the tumor-specific expression of a novel lncRNA that we have named Endogenous retroViral-associated ADenocarcinoma RNA or âEVADRâ, by analyzing RNA-seq data derived from colorectal tumors and matched normal control tissues. Subsequent analysis of TCGA RNA-seq data revealed the striking association of EVADR with adenocarcinomas, which are tumors of glandular origin. Moderate to high levels of EVADR were detected in 25 to 53% of colon, rectal, lung, pancreas and stomach adenocarcinomas (mean = 30 to 144 FPKM), and EVADR expression correlated with decreased patient survival (Cox regression; hazard ratio = 1.47, 95% confidence interval = 1.06 to 2.04, P = 0.02). In tumor sites of non-glandular origin, EVADR expression was detectable at only very low levels and in less than 10% of patients. For EVADR, a MER48 ERV element provides an active promoter to drive its transcription. Genome-wide, MER48 insertions are associated with nine lncRNAs, but none of the MER48-associated lncRNAs other than EVADR were consistently expressed in adenocarcinomas, demonstrating the specific activation of EVADR. The sequence and structure of the EVADR locus is highly conserved among Old World monkeys and apes but not New World monkeys or prosimians, where the MER48 insertion is absent. Conservation of the EVADR locus suggests a functional role for this novel lncRNA in humans and our closest primate relatives.
Conclusions
Our results describe the specific activation of a highly conserved ERV-lncRNA in numerous cancers of glandular origin, a finding with diagnostic, prognostic and therapeutic implications
General Solutions for Tunneling of Scalar Fields with Quartic Potentials in de Sitter Space
The tunneling rates for scalar fields with quartic potentials in de Sitter
space in the limit of no gravitational back reaction are calculated numerically
and the results are fitted by analytic formulae.Comment: (Contours in Figure 1 corrected, two-dimensional fitting coefficient
corrected, references added.), 16 pages, KUNS 124
Cosmology with a TeV mass GUT Higgs
The most natural way to break the GUT gauge symmetry is with a Higgs field
whose vacuum expectation value is of order 10^{16}\,\mbox{GeV} but whose mass
is of order to 10^3\,\mbox{GeV}. This can lead to a cosmological
history radically different from what is usually assumed to have occurred
between the standard inflationary and nucleosynthesis epochs, which may solve
the gravitino and Polonyi/moduli problems in a natural way.Comment: 4 pages, revte
Common Avian Infection Plagued the Tyrant Dinosaurs
Abstract Background: Tyrannosaurus rex and other tyrannosaurid fossils often display multiple, smooth-edged full-thickness erosive lesions on the mandible, either unilaterally or bilaterally. The cause of these lesions in the Tyrannosaurus rex specimen FMNH PR2081 (known informally by the name 'Sue') has previously been attributed to actinomycosis, a bacterial bone infection, or bite wounds from other tyrannosaurids
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