15 research outputs found
The kinetics of Ringer?s solution in young and elderly patients during induction of general anesthesia with propofol and epidural anesthesia with ropivacaine
Regional Tissue Metabolism During Open or Endovascular Abdominal Aortic Aneurysm Surgery
Crystalloid Preload versus Rapid Crystalloid Administration after Induction of Spinal Anaesthesia (Coload) for Elective Caesarean Section
Dynamics of vascular volume and hemodilution of lactated Ringerâs solution in patients during induction of general and epidural anesthesia
Objective: To investigate the dynamics of vascular volume and the plasma dilution of lactated Ringerâs solution in patients during the induction of general and epidural anesthesia. Methods: The hemodilution of i.v. infusion of 1000 ml of lactated Ringerâs solution over 60 min was studied in patients undergoing general (n=31) and epidural (n=22) anesthesia. Heart rate, arterial blood pressure and hemoglobin (Hb) concentration were measured every 5 min during the study. Surgery was not started until the study period had been completed. Results: General anesthesia caused the greater decrease of mean arterial blood pressure (MAP) (mean 15% versus 9%; P<0.01) and thereby followed by a more pronounced plasma dilution, blood volume expansion (VE) and blood volume expansion efficiency (VEE). A strong linear correlation between hemodilution and the reduction in MAP (r=â0.50; P<0.01) was found. At the end of infusion, patients undergoing general anesthesia retained 47% (SD 19%) of the infused fluid in the circulation, while epidural anesthesia retained 29% (SD 13%) (P<0.001). Correspondingly, a fewer urine output (mean 89 ml versus 156 ml; P<0.05) and extravascular expansion (454 ml versus 551 ml; P<0.05) were found during general anesthesia. Conclusion: We concluded that the induction of general anesthesia caused more hemodilution, volume expansion and volume expansion efficiency than epidural anesthesia, which was triggered only by the lower MAP