System size and beam energy dependence of azimuthal anisotropy from PHENIX

We present azimuthal anisotropy measurements in Au+Au and Cu+Cu collisions at $\sqrt{s_{NN}}$ = 62.4 and 200 GeV. Comparison between reaction plane and cumulant $v_2$ measurements in Au+Au collisions at $\sqrt{s_{NN}}$ = 200 GeV show that non-flow contributions, originating mainly from jets, influence the extracted $v_2$ for $p_T$ $\gtrsim$ 3.5 GeV/c. Number of constituent quark (NCQ) scaling of $v_2$, when studied as a function of transverse kinetic energy $KE_T$, is seen to hold for Au+Au collisions at $\sqrt{s_{NN}}$ = 62.4 and 200 GeV and for Cu+Cu collisions at $\sqrt{s_{NN}}$ = 200 GeV for $KE_{T}$ $\lesssim$ 1 GeV/c. Differential hexadecupole flow $v_4$ seems to exhibit scaling with integral $v_2$ for centrality $\le$ 40% as has been observed for differential $v_2$.Comment: 4 pages, 3 figures, Proceedings of the QM2008 Conference, Jaipur, India February 4-10 200

Measurements of Cold Nuclear Matter Effects on J/psi in the PHENIX Experiment via Deuteron-Gold Collisions

A new calculation of R_{dAu} has been performed using the 2003 d+Au data and the higher-statistics 2005 p+p data. These nuclear modification factors are compared to calculations using nuclear-modified PDFs and a J/psi breakup cross section is extracted. These values are then used to project the cold nuclear matter effects in Au+Au collisions. Additionally, a more data-driven projection is performed.Comment: 4 pages, 6 figures, proceedings for Quark Matter 200

Patients with cancer on the ICU: the times they are changing

A recent paper by Taccone and coworkers showed that 15% of patients from 198 European intensive care units (ICUs) had a malignancy, mostly solid tumors but also hematological malignancies. Over the past years, the prognosis of cancer patients has improved significantly, even when ICU admission is necessary. Refusal of ICU admission should not be based on a diagnosis of cancer as the underlying condition. In contrast, these decisions should be based on the availability of treatment options, and on patients' own preferences

A review of shear stress sign convention in interpreting Mohrs circle

pre-printThe pole of planes method is a popular technique for interpreting Mohr's circle to determine the stresses (normal and shear) on planes of differing rotations in 2-D space. A survey of undergraduate textbooks on soil mechanics shows differing viewpoints on the sign convention for interpreting the shear stresses. This paper makes a rigorous evaluation of the consequences of using a clockwise (CW) or counterclockwise (CCW) positive sign convention for the proper interpretation of Mohr's circle of stresses. In either case, the shear stress axis is considered positive upwards while the normal stress axis is considered positive to the right. It was found that if the shear stresses acting on an element are considered CW positive, the resulting stresses found on a rotated plane do not satisfy static equilibrium. However, the stresses determined using a CCW sign convention do satisfy static equilibrium and hence, if the pole method is to be used to interpret Mohr's circle for stresses, a CCW positive sign convention for shear stresses must be used

Reusability Report: Comparing gradient descent and monte carlo tree search optimization of quantum annealing schedules

We provide a reusability report of the method presented by Chen et al. in "Optimizing quantum annealing schedules with Monte Carlo tree search enhanced with neural networks" and add further benchmarks on Max-Cut problems.Comment: 5 pages 3 figures. Nat Mach Intell (2022

Is it possible to increase the sustainability of arable and ruminant agriculture by reducing inputs?

Until recently, agricultural production was optimised almost exclusively for profit but now farming is under pressure to meet environmental targets. A method is presented and applied for optimising the sustainability of agricultural production systems in terms of both economics and the environment. Components of the agricultural production chain are analysed using environmental life-cycle assessment (LCA) and a financial value attributed to the resources consumed and burden imposed on the environment by agriculture, as well as to the products. The sum of the outputs is weighed against the inputs and the system considered sustainable if the value of the outputs exceeds those of the inputs. If this ratio is plotted against the sum of inputs for all levels of input, a diminishing returns curve should result and the optimum level of sustainability is located at the maximum of the curve. Data were taken from standard economic almanacs and from published LCA reports on the extent of consumption and environmental burdens resulting from farming in the UK. Land-use is valued using the concept of ecosystem services. Our analysis suggests that agricultural systems are sustainable at rates of production close to current levels practiced in the UK. Extensification of farming, which is thought to favour non-food ecosystem services, requires more land to produce the same amount of food. The loss of ecosystem services hitherto provided by natural land brought into production is greater than that which can be provided by land now under extensive farming. This loss of ecosystem service is large in comparison to the benefit of a reduction in emission of nutrients and pesticides. However, food production is essential, so the coupling of subsidies that represent a relatively large component of the economic output in EU farming, with measures to reduce pollution are well-aimed. Measures to ensure that as little extra land is brought into production as possible or that marginal land is allowed to revert to nature would seem to be equally well-aimed, even if this required more intensive use of productive areas. We conclude that current arable farming in the EU is sustainable with either realistic prices for products or some degree of subsidy and that productivity per unit area of land and greenhouse gas emission (subsuming primary energy consumption) are the most important pressures on the sustainability of farming

Comprehensive Assessment of GPR68 Expression in Normal and Neoplastic Human Tissues Using a Novel Rabbit Monoclonal Antibody

GPR68 (OGR1) belongs to the proton-sensing G protein-coupled receptors that are involved in cellular adaptations to pH changes during tumour development. Although expression of GPR68 has been described in many tumour cell lines, little is known about its presence in human tumour entities. We characterised the novel rabbit monoclonal anti-human GPR68 antibody 16H23L16 using various cell lines and tissue specimens. The antibody was then applied to a large series of formalin-fixed, paraffin-embedded normal and neoplastic human tissue samples. Antibody specificity was demonstrated in a Western blot analysis of GPR68-expressing cells using specific siRNAs. Immunocytochemical experiments revealed pH-dependent changes in subcellular localisation of the receptor and internalisation after stimulation with lorazepam. In normal tissue, GPR68 was present in glucagon-producing islet cells, neuroendocrine cells of the intestinal tract, gastric glands, granulocytes, macrophages, muscle layers of arteries and arterioles, and capillaries. GPR68 was also expressed in neuroendocrine tumours, where it may be a positive prognostic factor, in pheochromocytomas, cervical adenocarcinomas, and endometrial cancer, as well as in paragangliomas, medullary thyroid carcinomas, gastrointestinal stromal tumours, and pancreatic adenocarcinomas. Often, tumour capillaries were also strongly GPR68-positive. The novel antibody 16H23L16 will be a valuable tool for basic research and for identifying GPR68-expressing tumours during histopathological examinations

A 19-channel d.c. SQUID magnetometer system for brain research

A 19-channel d.c. SQUID magnetometer system for neuromagnetic investigations is under constuction. The first-order gradiometers for sensing the signal are placed in a hexagonal configuration. D.c. SQUIDs based on niobium/aluminium technology have been developed, leading to a field sensitivity of about 5 fT/ Hz. SQUID read-out is realized with a resonant transformer circuit at 100 kHz. The multichannel control and detection electronics are compactly built