Is neutrophil-lymphocyte ratio associated with the severity of allergic rhinitis in children?

WOS: 000382945900039PubMed ID: 26525883Neutrophil lymphocyte ratio (NLR) could be an important measure of systemic inflammation. There is a lack of knowledge about the neutrophil-lymphocyte ratio in rhinitis. We aimed to determine the relationship between the clinical parameters of allergic rhinitis and NLR in children. 438 children who were diagnosed with allergic rhinitis and followed up in our hospital were included in the study. The control group included 180 control children with no evidence of allergic disease. The immunoglobulin E levels, skin prick tests and complete blood count were measured. Mean NLR was 1.77 +/- A 1.67 in the study group and 1.70 +/- A 1.65 in the control group. Mean NLR was significantly higher in children with allergic rhinitis compared to controls (p 0.05). However, NLR was significantly higher in the moderate/severe AR compared to mild AR (p < 0.05). Mean NLR was statistically higher in children with allergic rhinitis compared to the control group. In addition, elevated ratio is associated with the severity of allergic rhinitis in children. Neutrophil-lymphocyte can be used as an indicator of inflammation in allergic rhinitis. But further studies are needed in this issue

Reply to the letter to the editor by satvinder singh bakshi concerning: Is neutrophil-lymphocyte ratio associated with the severity of allergic rhinitis in children?

WOS: 000382945900081PubMed ID: 27473295We would like to thank the author of the letter for contributing valuable comments to our article entitled ‘‘Is neutrophil–lymphocyte ratio associated with the severity of allergic rhinitis in children?’’ [1]. However, we think that the author has missed some points. First, all patients with any chronic disease were not enrolled in the trial as specified in the materials-method section of the article. This includes patients with Bell’s palsy, chronic tonsillitis and hearing loss. Second, regarding the relationship between the age, body mass index (BMI) and neutrophil–lymphocyte ratio (NLR), our trial was written in February 2015, submitted to the journal on June 28, 2015 and accepted on October 24. The publication date of the reference source is November 2015 [2]. Moreover, there were no differences in terms of age between groups in our trial. There is no consensus about NLR and BMI relationship within the literature. There are also publications in which no relationship has been detected between BMI and NLR

Does adenoid hypertrophy affect disease severity in children with allergic rhinitis?

WOS: 000393599900025PubMed ID: 27405740Our study aims to evaluate the presence of adenoid hypertrophy (AH) in children with allergic rhinitis (AR) and the association of AH disease severity and clinical laboratory finding from retrospective, cross-sectional, and nonrandomized trial. The study included 566 children being treated and followed up for allergic rhinitis. Skin prick test for the same allergens was performed for all patients. Adenoid tissue was analyzed by an ENT specialist and the diagnosis was confirmed based on the patient history, endoscopic physical examination and radiology. Adenoid hypertrophy was detected in 118 (21.2 %) of the children with AR. Children with and without AH did not differ statistically and significantly by gender, age, presence of atopy in the family, exposure to smoke (p > 0.05). Comparison of the groups for AR duration demonstrated significantly higher frequency of persistent rhinitis in patients with AH (p 0.05). On the other hand, sensitivity to Alternaria alternata was significantly more frequent in AR patients with AH (p = 0.032). The presence of AH increased the severity of the disease and prolongs disease duration. There was a negative relationship between AH and asthma in children with AR. AH is more common among children with mold sensitivity. AH should be considered and investigated particularly in non-asthmatic children with pronounced nasal congestion and A. alternata sensitivity

Reply to the letter to the editor by Viroj Wiwanitkit concerning: 'Is neutrophil-lymphocyte ratio associated with the severity of allergic rhinitis in children?'

WOS: 000382945900079PubMed ID: 27473294We appreciate to receive these constructive and valuable comments regarding our article entitled ‘‘Is neutrophil– lymphocyte ratio associated with the severity of allergic rhinitis in children?’’ [1]. As mentioned by Wiwanitkit, it is more feasible to analyze the blood samples on the same analyzer [2]. However, the results were obtained on two separate analyzers, as the analyzer used to perform complete blood count in our hospital was changed after August 2013. When the blood samples were re-analyzed in terms of the analyzers, neutrophil–lymphocyte ratio (NLR) values in the AR group were found to be higher before August 2013 and the difference was not statistically significant (p = 0.179)

Ischemia-modified albumin levels in patients with idiopathic sudden sensorineural hearing loss

Objectives: This study aims to investigate whether serum levels of ischemia-modified albumin (IMA) are associated with idiopathic sudden sensorineural hearing loss (ISSNHL). Patients and Methods: Between December 2015 and June 2017, a total of 17 patients (9 males, 8 females; mean age 49.4±18.0 years; range, 24 to 88 years) with ISSNHL and 24 age- and sex-matched healthy individuals (12 males, 12 females; mean age 44.5±13.3 years; range, 30 to 81 years) as the control group were included in the study. All patients underwent audiometric examination at the time of admission immediately before the beginning of the treatment and weekly after treatment initiation until one month using the Interacoustics AC40 audiometer. Serum IMA levels were evaluated using blood samples from the antecubital vein of both patient and control groups. The samples were centrifuged to separate the serum from the cells. Albumin cobalt binding test was used for IMA measurement. Results: The mean IMA level was 0.374±0.081 absorbance units (ABSU) (range, 0.205 to 0.536) in the study group at the time of diagnosis, 0.358±0.051 ABSU (range, 0.297 to 0.466) in the post-treatment period, at least four weeks after onset, and 0.358±0.053 ABSU (range, 0.281 to 0.434) in the control group. There was no statistically significant difference between the patient and control groups. The IMA levels of the patients with ISSNHL in the post-treatment period were lower than the onset of illness, although this difference was not statically significant (0.440). Conclusion: Our study results demonstrated that serum IMA levels in the patients with ISSNHL did not differ from the control group

Reply to the letter to the author concerning: 'Does adenoid hypertrophy affect disease severity in children with allergic rhinitis?'

WOS: 000425281500025PubMed ID: 29423746We would like to thank the author for making valuable comments about our article entitled “Does adenoid hypertrophy affect disease severity in children with allergic rhinitis?” [1]. However, we think that the reviewer has made several mistakes while evaluating the content of our article and the details of the literature. Firstly, as we have already pointed out in our trial, our study aims to evaluate the presence of adenoid hypertrophy (AH) in children with allergic rhinitis (AR) and the connection between AH disease severity and clinical laboratory findings. The aim of the study is not about exploring the effects of adenoidectomy on the patients with AR and A

Long term effects of palatal implant method in adult patients with simple snoring and obstructive sleep-apnea syndrome

WOS: 000354183900003PubMed ID: 25756254Objective. To investigate the long term effect and reliability of palatal implant surgery, which is a minimally invasive technique, used in simple snoring and obstructive sleep-apnea syndrome types based on objective and subjective data. Materials and Methods. Seventy-eight patients were included prospectively in this study. It has been possible to obtain preoperative and postoperative polysomnography results in 59 patients. The cases were followed-up for 8 months on average. Considering the apnea index and AHI values, the patients were divided into 5 groups, namely simple snoring (n=13), mild OSAS (n=21), moderate OSAS (n=17), severe OSAS (n=8), and the group on which polysomnography could not be performed, the no-polysomnography group (n=19). The cases were evaluated based on polysomnography and the Epworth Sleepiness Scale and visual analog scale filled by relatives or friends of the patients. Results. The AHI of 46 patients diagnosed with OSAS decreased from 14.9 to 10.14 (31% decline) (p=0.279). The AHI of 13 patients with simple snoring diagnosis reduced from 3.09 to 2.02 (p=0.033). A 40% improvement was observed in VAS of all cases. Implant rejection occurred in 7 of our cases and 3 patients experienced ecchymosis. Conclusion. It is concluded that palatal implant procedure is a good option for appropriate cases, it is equivalent to other methods in terms of treatment efficacy and that is more advantageous than other techniques in that it can be applied in office settings with low morbidity, is minimally invasive and brings about higher patient compliance

Spindle Cell Lipoma of the Hypopharynx

WOS: 000298011300007PubMed ID: 21850199Objective: We report a rare case of a spindle cell lipoma with atypical clinical course. Case report: A 51 year old female patient referred to our clinic with feeling of mass in the throat she had had for two years. The patient described difficulty in swallowing. Indirect laryngoscopy did not reveal any masses at bilateral pyriform sinuses, and the mucosa had a natural appearance. However, a mass with a stalk was detected in the side of the mouth when the patient retched. Endoscopic monitoring of the mass revealed its origin to be the left sinus pyriformis. No pathological structures could be detected in the indirect laryngoscopy taken after the patient gulped again. The mass was shown by magnetic resonance imaging to extend into the esophagus. It was removed using suspension microlaryngoscopy. Postoperative control revealed a complete healing at the excision site. Immunohistochemical examination for pathological diagnosis indicated a spindle cell lipoma. Conclusions: Laryngeal and hypopharyngeal lipomas are rare forms of benign laryngeal neoplasms. Their asymptomatic course makes diagnosis difficult. The patient is presented here with related clinical and pathological features

Spindle Cell Lipoma of the Hypopharynx

Objective: We report a rare case of a spindle cell lipoma with atypical clinical course.Case report: A 51 year old female patient referred to our clinic with feeling of mass in the throat she had had for two years. The patient described difficulty in swallowing. Indirect laryngoscopy did not reveal any masses at bilateral pyriform sinuses, and the mucosa had a natural appearance. However, a mass with a stalk was detected in the side of the mouth when the patient retched. Endoscopic monitoring of the mass revealed its origin to be the left sinus pyriformis. No pathological structures could be detected in the indirect laryngoscopy taken after the patient gulped again. The mass was shown by magnetic resonance imaging to extend into the esophagus. It was removed using suspension microlaryngoscopy. Postoperative control revealed a complete healing at the excision site. Immunohistochemical examination for pathological diagnosis indicated a spindle cell lipoma.Conclusions: Laryngeal and hypopharyngeal lipomas are rare forms of benign laryngeal neoplasms. Their asymptomatic course makes diagnosis difficult. The patient is presented here with related clinical and pathological features.</p