Restricted and Repetitive Behaviors as Predictors of Outcome in Autism Spectrum Disorders

Restricted and Repetitive Behaviors (RRBs) are core features of Autism Spectrum Disorders (ASDs). Efforts to understand the purpose of RRBs have raised questions about the significance of the presence of RRBs in the long-term outcome of children with ASDs. Some studies have reported that the presence of RRBs during preschool years is a negative prognostic indicator for later childhood (e.g., Charman et al., 2005), while others have failed to replicate this finding (e.g., Bopp et al., 2009). This study examined the effect of RRBs on later functioning in 40 children with ASDs. RRBs were examined at ages 1-2 and 3-5 years using direct observation and parent report. These scores were used to predict cognitive functioning, adaptive abilities, and ASD symptomatology at age 8-10 years. The results suggest that RRBs observed early in the preschool period do not predict later functioning. However, when RRBs are observed at age 3-5 years, they appear to be useful prognostic indicators. Specifically, more severe preoccupations with parts of objects, sensory interests and stereotyped motor movements observed between 3-5 years of age predicted less developed cognitive and adaptive skills, as well as greater ASD symptom severity at age 8-10 years. The relationship between RRBs in the late preschool period and school age outcome is not as strong as the relationship between cognitive functioning in the late preschool period and school age outcome. However, overall, these findings indicate that exhibiting RRBs in the late preschool period does appear to be a negative prognostic indicator for school-age outcome

Language comprehension and brain function in individuals with an optimal outcome from autism

Although Autism Spectrum Disorder (ASD) is generally a lifelong disability, a minority of individuals with ASD overcome their symptoms to such a degree that they are generally indistinguishable from their typically-developing peers. That is, they have achieved an Optimal Outcome (OO). The question addressed by the current study is whether this normalized behavior reflects normalized brain functioning, or alternatively, the action of compensatory systems. Either possibility is plausible, as most participants with OO received years of intensive therapy that could alter brain networks to align with typical function or work around ASD-related neural dysfunction. Individuals ages 8 to 21 years with high-functioning ASD (n = 23), OO (n = 16), or typical development (TD; n = 20) completed a functional MRI scan while performing a sentence comprehension task. Results indicated similar activations in frontal and temporal regions (left middle frontal, left supramarginal, and right superior temporal gyri) and posterior cingulate in OO and ASD groups, where both differed from the TD group. Furthermore, the OO group showed heightened “compensatory” activation in numerous left- and right-lateralized regions (left precentral/postcentral gyri, right precentral gyrus, left inferior parietal lobule, right supramarginal gyrus, left superior temporal/parahippocampal gyrus, left middle occipital gyrus) and cerebellum, relative to both ASD and TD groups. Behaviorally normalized language abilities in OO individuals appear to utilize atypical brain networks, with increased recruitment of language-specific as well as right homologue and other systems. Early intensive learning and experience may normalize behavioral language performance in OO, but some brain regions involved in language processing may continue to display characteristics that are more similar to ASD than typical development, while others show characteristics not like ASD or typical development