El llamado Templo de Júpiter de Clunia: propuesta de restitución

This paper proposes the restoration of the elevation of the so-called Temple of Jupiter in Clunia, based on different architectural elements, inter-related by a stylistic and dimensional criterion. Some typological traces of the plan are also evaluated, while establishing a relationship with other known temples in the western part of the Roman Empire.<br><br>En este trabajo se propone una restitución del alzado del llamado templo de Júpiter de Clunia a partir de diferentes elementos arquitectónicos relacionados entre sí con un criterio estilístico y dimensional. Se valoran también algunos rasgos tipológicos de la planta, todo ello con el objeto de intentar enmarcar cronológicamente su construcción y al mismo tiempo de establecer una relación con otros templos conocidos en la parte occidental del Imperio romano

La influencia de la educación emocional y la violencia escolar en niños de educación primaria en situaciones de vulnerabilidad: El efecto modulador de la autoestima y el sexo.

El objetivo del presente estudio analizar la relación entre la inteligencia emocional (IE) y la violencia escolar modulada por los niveles de autoestima y el sexo de un grupo de niños de educación primaria en situaciones de vulnerabilidad. Para ello se administran los cuestionarios CUVE3-EP (Álvarez-García, Núñez y Dobarro, 2013), TMMS-24 (Fernández-Berrocal, Extremera y Ramos, 2004) y una Escala de autoestima (Rosenberg, 1965) a una muestra de 84 alumnos, con edades comprendidas entre los 7 y los 13 años. Los resultados mostraron que la Inteligencia Emocional (IE) estuvo correlacionada de forma negativa y significativa con la violencia escolar y que, a mayor autoestima, menor violencia en mujeres, pero mayor violencia en hombres.<br /

DEXTER: Automatic Extraction of Domain-Specific Glossaries for Language Teaching

[EN] Many researchers emphasize the importance of corpora in the design of Language-for-Specific-Purposes courses in higher education. However, identifying those lexical units which belong to a given specific domain is often a complex task for language teachers, where simple introspection or concordance analysis does not really become effective. The goal of this paper is to describe DEXTER, an open-access platform for data mining and terminology management, whose aim is not only the search, retrieval, exploration and analysis of texts in domain-specific corpora but also the automatic extraction of specialized words from the domain.Financial support for this research has been provided by the DGI, Spanish Ministry of Education and Science, grant FFI2011-29798-C02-01.Periñán Pascual, JC.; Mestre-Mestre, EM. (2015). DEXTER: Automatic Extraction of Domain-Specific Glossaries for Language Teaching. Procedia Social and Behavioral Sciences. 198:377-385. https://doi.org/10.1016/j.sbspro.2015.07.45737738519

Uncoupled seasonal variability of transparent exopolymer and Coomassie stainable particles in coastal Mediterranean waters: Insights into sources and driving mechanisms

Transparent exopolymer particles (TEP) and Coomassie stainable particles (CSP) are gel-like particles, ubiquitous in the ocean, that affect important biogeochemical processes including organic carbon cycling by planktonic food webs. Despite much research on both groups of particles (especially TEP) over many years, whether they exist as distinctly stainable fractions of the same particles or as independent particles, each with different driving factors, remains unclear. To address this question, we examined the temporal dynamics of TEP and CSP over 2 complete seasonal cycles at 2 coastal sites in the Northwestern Mediterranean Sea, the Blanes Bay Microbial Observatory (BBMO) and the L’Estartit Oceanographic Station (EOS), as well as their spatial distribution along a coast-to-offshore transect. Biological, chemical, and physical variables were measured in parallel. Surface concentrations (mean + standard deviation [SD]) of TEP were 36.7 + 21.5 µg Xanthan Gum (XG) eq L–1 at BBMO and 36.6 + 28.3 µg XG eq L–1 at EOS; for CSP, they were 11.9 + 6.1 µg BSA eq L–1 at BBMO and 13.0 + 5.9 µg BSA eq L–1 at EOS. Seasonal variability was more evident at EOS, where surface TEP and CSP concentrations peaked in summer and spring, respectively, and less predictable at the shore-most station, BBMO. Vertical distributions between surface and 80 m, monitored at EOS, showed highest TEP concentrations within the surface mixed layer during the stratification period, whereas CSP concentrations were highest before the onset of summer stratification. Phytoplankton were the main drivers of TEP and CSP distributions, although nutrient limitation and saturating irradiance also appeared to play important roles. The dynamics and distribution of TEP and CSP were uncoupled both in the coastal sites and along the transect, suggesting that they are different types of particles produced and consumed differently in response to environmental variability

Genome-Wide Association Study for Serum Omega-3 and Omega-6 Polyunsaturated Fatty Acids: Exploratory Analysis of the Sex-Specific Effects and Dietary Modulation in Mediterranean Subjects with Metabolic Syndrome

Many early studies presented beneficial effects of polyunsaturated fatty acids (PUFA) on cardiovascular risk factors and disease. However, results from recent meta-analyses indicate that this effect would be very low or nil. One of the factors that may contribute to the inconsistency of the results is that, in most studies, genetic factors have not been taken into consideration. It is known that fatty acid desaturase (FADS) gene cluster in chromosome 11 is a very important determinant of plasma PUFA, and that the prevalence of the single nucleotide polymorphisms (SNPs) varies greatly between populations and may constitute a bias in meta-analyses. Previous genome-wide association studies (GWAS) have been carried out in other populations and none of them have investigated sex and Mediterranean dietary pattern interactions at the genome-wide level. Our aims were to undertake a GWAS to discover the genes most associated with serum PUFA concentrations (omega-3, omega-6, and some fatty acids) in a scarcely studied Mediterranean population with metabolic syndrome, and to explore sex and adherence to Mediterranean diet (MedDiet) interactions at the genome-wide level. Serum PUFA were determined by NMR spectroscopy. We found strong robust associations between various SNPs in the FADS cluster and omega-3 concentrations (top-ranked in the adjusted model: FADS1-rs174547, p = 3.34 × 10-14; FADS1-rs174550, p = 5.35 × 10-14; FADS2-rs1535, p = 5.85 × 10-14; FADS1-rs174546, p = 6.72 × 10-14; FADS2-rs174546, p = 9.75 × 10-14; FADS2- rs174576, p = 1.17 × 10-13; FADS2-rs174577, p = 1.12 × 10-12, among others). We also detected a genome-wide significant association with other genes in chromosome 11: MYRF (myelin regulatory factor)-rs174535, p = 1.49 × 10-12; TMEM258 (transmembrane protein 258)-rs102275, p = 2.43 × 10-12; FEN1 (flap structure-specific endonuclease 1)-rs174538, p = 1.96 × 10-11). Similar genome-wide statistically significant results were found for docosahexaenoic fatty acid (DHA). However, no such associations were detected for omega-6 PUFAs or linoleic acid (LA). For total PUFA, we observed a consistent gene*sex interaction with the DNTTIP2 (deoxynucleotidyl transferase terminal interacting protein 2)-rs3747965 p = 1.36 × 10-8. For adherence to MedDiet, we obtained a relevant interaction with the ME1 (malic enzyme 1) gene (a gene strongly regulated by fat) in determining serum omega-3. The top-ranked SNP for this interaction was ME1-rs3798890 (p = 2.15 × 10-7). In the regional-wide association study, specifically focused on the FADS1/FASD2/FADS3 and ELOVL (fatty acid elongase) 2/ELOVL 5 regions, we detected several statistically significant associations at p < 0.05. In conclusion, our results confirm a robust role of the FADS cluster on serum PUFA in this population, but the associations vary depending on the PUFA. Moreover, the detection of some sex and diet interactions underlines the need for these associations/interactions to be studied in all specific populations so as to better understand the complex metabolism of PUFA

Biochemical Profile and Antioxidant Properties of Propolis from Northern Spain

[EN] The antioxidant, anti-inflammatory, and antimicrobial characteristics of propolis, a bioactive compound collected from hives, have prompted its use in the food sector in recent times. This study investigated the physicochemical characteristics, phenolic profile, and antioxidant capacity of 31 propolis extracts collected from Northern Spain. The physicochemical composition (resins, waxes, ashes mineral content, and heavy metals) was within the allowable regulatory limits. The analysis of bioactive compounds enabled the identification of 51 constituents: flavonoids (apigenin, catechin, chrysin, quercetin, and pinocembrin) and phenolic acids (caffeic, ferulic, and coumaric). The mean value of total polyphenols was 42.72 ± 13.19 Pinocembrin–Galangin Equivalents/100 g, whereas a range between 1.64 ± 0.04 and 4.95 ± 0.36 Quercetin Equivalents (QE) g/100 g was found for total flavonoids content. The determination of bioactivities revealed significant antioxidant capacity using DPPH (1114.28 ± 10.39 µM Trolox Equivalents and 3487.61 ± 318.66 µM Vitamin C Equivalents). Resin content in propolis samples was positively and significantly correlated with both polyphenols (rho = 0.365; p = 0.043) and flavonoid composition (rho = 0.615; p = 0.000) as well as the antioxidant capacity TEAC DPPH (rho = 0.415; p = 0.020). A multiple regression analysis modeled the correlation between resin composition, flavonoids, and TEAC DPPH values, yielding a significant regression equation (R2 = 0.618; F (2,28) = 22.629; p < 0.000; d = 2.299). Therefore, evaluating physicochemical parameters and biological activities provides a promising framework for predicting propolis’ quality and antioxidant properties, thus suggesting its potential as a functional and bioactive compound for the food industry.S

Interplay of disorder and nonlinearity in Klein-Gordon models: Immobile kinks

We consider Klein-Gordon models with a $\delta$-correlated spatial disorder. We show that the properties of immobile kinks exhibit strong dependence on the assumptions as to their statistical distribution over the minima of the effective random potential. Namely, there exists a crossover from monotonically increasing (when a kink occupies the deepest potential well) to the non-monotonic (at equiprobable distribution of kinks over the potential minima) dependence of the average kink width as a function of the disorder intensity. We show also that the same crossover may take place with changing size of the system.Comment: 7 pages, 4 figure

Chronological Age Interacts with the Circadian Melatonin Receptor 1B Gene Variation, Determining Fasting Glucose Concentrations in Mediterranean Populations. Additional Analyses on Type-2 Diabetes Risk

Gene-age interactions have not been systematically investigated on metabolic phenotypes and this modulation will be key for a better understanding of the temporal regulation in nutrigenomics. Taking into account that aging is typically associated with both impairment of the circadian system and a decrease in melatonin secretion, we focused on the melatonin receptor 1B (MTNR1B)-rs10830963 C>G variant that has been associated with fasting glucose concentrations, gestational diabetes, and type-2 diabetes. Therefore, our main aim was to investigate whether the association between the MTNR1B-rs10830963 polymorphism and fasting glucose is age dependent. Our secondary aims were to analyze the polymorphism association with type-2 diabetes and explore the gene-pregnancies interactions on the later type-2 diabetes risk. Three Mediterranean cohorts (n = 2823) were analyzed. First, a cross-sectional study in the discovery cohort consisting of 1378 participants (aged 18 to 80 years; mean age 41 years) from the general population was carried out. To validate and extend the results, two replication cohorts consisting of elderly individuals were studied. In the discovery cohort, we observed a strong gene-age interaction (p = 0.001), determining fasting glucose in such a way that the increasing effect of the risk G-allele was much greater in young (p = 5.9 × 10-10) than in elderly participants (p = 0.805). Consistently, the association of the MTNR1B-rs10830963 polymorphism with fasting glucose concentrations in the two replication cohorts (mean age over 65 years) did not reach statistical significance (p > 0.05 for both). However, in the elderly cohorts, significant associations between the polymorphism and type-2 diabetes at baseline were found. Moreover, in one of the cohorts, we obtained a statistically significant interaction between the MTNR1B polymorphism and the number of pregnancies, retrospectively assessed, on the type-2 diabetes risk. In conclusion, the association of the MTNR1B-rs10830963 polymorphism with fasting glucose is age-dependent, having a greater effect in younger people. However, in elderly subjects, associations of the polymorphism with type-2 diabetes were observed and our exploratory analysis suggested a modulatory effect of the number of past pregnancies on the future type-2 diabetes genetic risk

Diseño de material docente para el aprendizaje interdisciplinar en el Grado en Enfermería

En el marco de experimentación del Espacio Europeo de Educación Superior (EEES) se ha planteado una experiencia docente universitaria de carácter interdisciplinar en asignaturas impartidas por profesorado del Departamento de Psicología de la Salud y del Departamento de Enfermería de la Universidad de Alicante. El presente estudio persigue un doble objetivo, por una parte, innovar con metodologías de colaboración y planificación de actividades docentes entre el profesorado de distintas áreas de conocimiento y cursos del Grado en Enfermería. Por otro lado, incrementar la relación entre disciplinas y promover el desarrollo de competencias transversales recogidas en el plan docente de las asignaturas. La metodología de trabajo se basa en la participación activa en red de los profesores de las asignaturas vinculadas. Las actividades programadas comprenden la preparación de contenidos comunes a distribuir entre asignaturas, la elaboración de materiales docentes en un formato dinámico e interactivo y en su publicación en la plataforma institucional, Campus Virtual y en formato de libre acceso en el Repositorio Institucional de la Universidad de Alicante (RUA). Los resultados que se esperan obtener, incluyen el material docente elaborado, el proceso de evaluación diseñado y la posible transferencia de los mismos a otras titulaciones