Clasificador óptico para hojas de tabaco.

Las tres características fundamentales que definen la calidad y madurez del tabaco son el color, la textura y los aromas, aunque es color es el factor más extendido para su determinación Sin embargo, el color varia de forma continua desde el verde hasta el amarillo y naranja a lo largo del proceso de maduración, de manera que las distintas categorías comerciales de color muestran amplias zonas difusas entre ellas. El materia empleado en e! presente trabajo fue provisto por CETARS A en las campañas l994 y 1995 En ambos casos, las muestras fueron previamente clasificadas por sus expertos en 12 categorías comerciales de color. Las determinaciones objetivas de color se llevaron a cabo empleando un espectrofotómetro (Monolight). Posteriormente el espectro fue recalculado afectándolo del las características del íluminante habitualmente empleado por los expertos (F7). A través de la integración del espectro se determinaron asimismo las coordenadas triestímulo de color (X.Y.Z), equivalentes al proceso de asimilación del color por el ojo humano. Los resultados obtenidos con el presente estudio pueden resumirse de la siguiente manera. 1.- las categorías comerciales de color provistas por los expertos mostraron un alto índice de solapamiento entre ellas, para las coordenadas XYZ, debido a la ausencia de. homogeneidad características de toda muestra biológica (c v. de 20.14% y 10.08% en 1994 y 1995). 2.- a través de un clasificador no-supervisado sobre observaciones de color se ha creado una nueva base de color similar en valores medios a las de CETARSA pero con menor variabilidad intragrupo (6.31% y 5.81% en 1994 y 1995 este sistema permite agrupar observaciones de color similares independientemente de las hojas a las que pertenezcan. 3.- empleo de un clasificador bayesiano sobre la nueva base de color permite clasificar los puntos de color de una hoja con errores inferiores al 4% en ambas campañas. 4.- se ha desarrollado un criterio global de clasificación de hojas en función del color y la variabilidad de color de distintas muestras dentro de una hoja El sistema será validado "in situ" en las próximas campañas

Magnetic resonance imaging as a predictor of therapeutic response to pasireotide in acromegaly

Acromegaly; Magnetic resonance imaging; PasireotideAcromegàlia; Imatges per ressonància magnètica; PasireòtidaAcromegalia; Imagen por resonancia magnética; PasireotidaObjective Hyperintensity signal in T2-weighted magnetic resonance imaging (MRI) has been related to better therapeutic response during pasireotide treatment in acromegaly. The aim of the study was to evaluate T2 MRI signal intensity and its relation with pasireotide therapeutic effectiveness in real-life clinical practice. Design, Patients and Measurements Retrospective multicentre study including acromegaly patients treated with pasireotide. Adenoma T2-weighted MRI signal at diagnosis was qualitatively classified as iso-hyperintense or hypointense. Insulin-like growth factor (IGF-I), growth hormone (GH) and tumour volume reduction were assessed after 6 and 12 months of treatment and its effectiveness evaluated according to baseline MRI signal. Hormonal response was considered ‘complete’ when normalization of IGF-I levels was achieved. Significant tumour shrinkage was defined as a volume reduction of ≥25% from baseline. Results Eighty-one patients were included (48% women, 50 ± 1.5 years); 93% had previously received somatostatin receptor ligands (SRLs) treatment. MRI signal was hypointense in 25 (31%) and hyperintense in 56 (69%) cases. At 12 months of follow-up, 42/73 cases (58%) showed normalization of IGF-I and 37% both GH and IGF-I. MRI signal intensity was not associated with hormonal control. 19/51 cases (37%) presented a significant tumour volume shrinkage, 16 (41%) from the hyperintense group and 3 (25%) from the hypointense. Conclusions T2-signal hyperintensity was more frequently observed in pasireotide treated patients. Almost 60% of SRLs resistant patients showed a complete normalization of IGF-I after 1 year of pasireotide treatment, regardless of the MRI signal. There was also no difference in the percentage tumour shrinkage over basal residual volume between the two groups.This work was partially supported by grants from Instituto de Salud Carlos III, Madrid, (PMP 15/00027, PMP22/00021 and PI22/01364) to M. P-D

Role of bacterial community composition as a driver of the small-sized phytoplankton community structure in a productive coastal system

Financiado para publicación en acceso aberto: Universidade de Vigo/CISUGWe present here the first detailed description of the seasonal patterns in bacterial community composition (BCC) in shelf waters off the Ría de Vigo (Spain), based on monthly samplings during 2 years. Moreover, we studied the relationship between bacterial and small-sized eukaryotic community composition to identify potential biotic interactions among components of these two communities. Bacterial operational taxonomic unit (OTU) richness and diversity systematically peaked in autumn–winter, likely related to low resource availability during this period. BCC showed seasonal and vertical patterns, with Rhodobacteraceae and Flavobacteriaceae families dominating in surface waters, and SAR11 clade dominating at the base of the photic zone (30 m depth). BCC variability was significantly explained by environmental variables (e.g., temperature of water, solar radiation, or dissolved organic matter). Interestingly, a strong and significant correlation was found between BCC and small-sized eukaryotic community composition (ECC), which suggests that biotic interactions may play a major role as structuring factors of the microbial plankton in this productive area. In addition, co-occurrence network analyses revealed strong and significant, mostly positive, associations between bacteria and small-sized phytoplankton. Positive associations likely result from mutualistic relationships (e.g., between Dinophyceae and Rhodobacteraceae), while some negative correlations suggest antagonistic interactions (e.g., between Pseudo-nitzchia sp. and SAR11). These results support the key role of biotic interactions as structuring factors of the small-sized eukaryotic community, mostly driven by positive associations between small-sized phytoplankton and bacteria.Xunta de Galicia | Ref. EM2013/023Xunta de Galicia | Ref. ED481A-2019/290Xunta de Galicia | Ref. ED431I 2020/03Ministerio de Economía y Competitividad | Ref. CTM2017-83362-RMinisterio de Ciencia e Innovación | Ref. PID2019-110011RB-C3

Restrictive diets are unnecessary for colonoscopy: Non-inferiority randomized trial

Endoscopy Lower GI Tract; CRC screening; Quality and logistical aspectsEndoscopia tracto gastrointestinal inferior; Cribado CCR; Aspectos logísticosEndoscòpia tracte gastrointestinal inferior; Cribratge CCR; Qualitat i aspectes logísticsBackground and study aims In colonoscopy, preparation is often regarded as the most burdensome part of the intervention. Traditionally, specific diets have been recommended, but the evidence to support this policy is insufficient. The aim of this study was to evaluate the impact of the decision not to follow a restrictive diet on bowel preparation and colonoscopy outcomes. Patients and methods This was a multicenter, controlled, non-inferiority randomized trial with FIT-positive screening colonoscopy. The subjects were assigned to follow the current standard (1-day low residue diet [LRD]) or a liberal diet. The allocation was balanced for the risk of inadequate cleansing using the Dik et al. score. All participants received the same instructions for morning colonoscopy preparation. The primary outcome was the rate of adequate preparations as defined by the Boston Bowel Preparation Scale. Secondary outcomes included tolerability and measures of colonoscopy performance and quality. Results A total of 582 subjects were randomized. Of these, 278 who received the liberal diet and 275 who received the 1-day LRD were included in the intent-to-treat analysis. Non-inferiority was demonstrated with adequate preparation rates of 97.8% in the 1-day LRD and 96.4% in the liberal diet group. Tolerability was higher with the liberal diet (94.7% vs. 83.2%). No differences were found with respect to cecal intubation time, aspirated volume, or length of the examination. Global and right colon average adenoma detection rates per colonoscopy were similar. Conclusions The liberal diet was non-inferior to the 1-day LRD, and increased tolerability. Colonoscopy performance and quality were not affected. (NCT05032794)

Peer aggression and victimisation: social behaviour strategies in early childhood in Spain

The present study aims to examine the issue of peer aggression and victimisation in early childhood, with a focus on the associated social behaviour strategies (aggressiveness, prosociality, dominance and social insecurity). A sample of 227 children (58.1% girls, n = 132) between the ages of 4 and 7 years (M = 5.61; SD = 1. 03) participated in the study. Teacher reports and peer nominations of physical and verbal aggression and victimisation were analysed. Results showed an association between aggressiveness and insecurity and being nominated as a physical and verbal aggressor by peers. Being nominated as a physical victim was associated with aggressiveness and dominance; and for verbal victim with aggressiveness and prosociality. Differences were found between boys and girls in verbal aggression and victimisation. The current study contributes to a better understanding of the emergence of peer aggression and victimisation in relation to social processes in early childhood and has implications for the prevention of the later appearance of bullying

An Antimethanogenic Nutritional Intervention in Early Life of Ruminants Modifies Ruminal Colonization by Archaea

The aim of this work was to study whether feeding a methanogen inhibitor from birth of goat kids and their does has an impact on the archaeal population colonizing the rumen and to what extent the impact persists later in life. Sixteen goats giving birth to two kids were used. Eight does were treated (D+) with bromochloromethane after giving birth and over 2 months. The other 8 goats were not treated (D−). One kid per doe in both groups was treated with bromochloromethane (k+) for 3 months while the other was untreated (k−), resulting in four experimental groups: D+/k+, D+/k−, D−/k+, and D−/k−. Rumen samples were collected from kids at weaning and 1 and 4 months after (3 and 6 months after birth) and from does at the end of the treating period (2 months). Pyrosequencing analyses showed a modified archaeal community composition colonizing the rumen of kids, although such effect did not persist entirely 4 months after; however, some less abundant groups remained different in treated and control animals. The different response on the archaeal community composition observed between offspring and adult goats suggests that the competition occurring in the developing rumen to occupy different niches offer potential for intervention

Causes of death in a contemporary cohort of patients with invasive aspergillosis

Information regarding the processes leading to death in patients with invasive aspergillosis (IA) is lacking. We sought to determine the causes of death in these patients, the role that IA played in the cause, and the timing of death. The factors associated with IA-related mortality are also analyzed. We conducted a multicenter study (2008-2011) of cases of proven and probable IA. The causes of death and whether mortality was judged to be IA-related or IA-unrelated were determined by consensus using a six-member review panel. A multivariate analysis was performed to determine risk factors for IA-related death. Of 152 patients with IA, 92 (60.5%) died. Mortality was judged to be IA-related in 62 cases and IA-unrelated in 30. The most common cause of IA-related death was respiratory failure (50/62 patients), caused primarily by Aspergillus infection, although also by concomitant infections or severe comorbidities. Progression of underlying disease and bacteremic shock were the most frequent causes of IA-unrelated death. IA-related mortality accounted for 98% and 87% of deaths within the first 14 and 21 days, respectively. Liver disease (HR 4.54; 95% CI, 1.69-12.23) was independently associated with IA-related mortality, whereas voriconazole treatment was associated with reduced risk of death (HR 0.43; 95% CI, 0.20-0.93). In conclusion, better management of lung injury after IA diagnosis is the main challenge for physicians to improve IA outcomes. There are significant differences in causes and timing between IA-related and IA-unrelated mortality and these should be considered in future research to assess the quality of IA car

Severe vaccine-acquired rotavirus infection in an infant with primary intestinal lymphangiectasia

Clinical letterTo date, severe cases of vaccine-related rotavirus infection have only been reported in infants with severe combined immunodeficiency after immunization. We describe the first case of vaccine-related rotavirus gastroenteritis in an infant with intestinal lymphangiectasia.S