Adapting Text-based Dialogue State Tracker for Spoken Dialogues

Although there have been remarkable advances in dialogue systems through the dialogue systems technology competition (DSTC), it remains one of the key challenges to building a robust task-oriented dialogue system with a speech interface. Most of the progress has been made for text-based dialogue systems since there are abundant datasets with written corpora while those with spoken dialogues are very scarce. However, as can be seen from voice assistant systems such as Siri and Alexa, it is of practical importance to transfer the success to spoken dialogues. In this paper, we describe our engineering effort in building a highly successful model that participated in the speech-aware dialogue systems technology challenge track in DSTC11. Our model consists of three major modules: (1) automatic speech recognition error correction to bridge the gap between the spoken and the text utterances, (2) text-based dialogue system (D3ST) for estimating the slots and values using slot descriptions, and (3) post-processing for recovering the error of the estimated slot value. Our experiments show that it is important to use an explicit automatic speech recognition error correction module, post-processing, and data augmentation to adapt a text-based dialogue state tracker for spoken dialogue corpora.Comment: 8 pages, 5 figures, Accepted at the DSTC 11 Workshop to be located at SIGDIAL 202

Analytical Study on Thermal and Mechanical Design of Printed Circuit Heat Exchanger

The analytical methodologies for the thermal design, mechanical design and cost estimation of printed circuit heat exchanger are presented in this study. In this study, three flow arrangements of parallel flow, countercurrent flow and crossflow are taken into account. For each flow arrangement, the analytical solution of temperature profile of heat exchanger is introduced. The size and cost of printed circuit heat exchangers for advanced small modular reactors, which employ various coolants such as sodium, molten salts, helium, and water, are also presented

Running Performance Profile among Playing Positions and Quarters in Elite Female Field Hockey Players

PURPOSE This study aimed to compare the running-related variables during competitions across playing positions and quarters in elite female field hockey players. METHODS A total of 136 data from 41 players were collected using GPS units during national-level competitions. The running-related variables included the total distance covered (TD, unit: m), relative distance (RD, unit: m/min), proportion of low-(LID, 0-6 km/h), moderate-(MID, 6.1-15 km/h), and high-intensity (HID, ≥15.1 km/h) distance of the total distance covered (unit: %), and sprint efforts (SE, ≥19.1 km/h, ≥1s; unit: bouts). RESULTS The defenders’ TD (5,619.77±1,046.14 m) was shorter than that of midfielders (5,475±1,043.33 m) and forwards (4,684.22± 1,066.11 m), and the RD of midfielders (103.64±9.10 m/min) was longer than that of forwards (99.03±10.37 m/min) and defenders (92.42±10.85 m/min). The midfielders had the highest MID(47.08±5.51%), while the highest HID (16.23±3.62%) was observed in the forwards. Defenders performed 35.12±5.25 bouts, with the highest number of sprints among the playing positions. Regardless of the playing positions, 1 quarter had the highest TD, RD, and HID, and the SE was the highest in 4 quarter. CONCLUSIONS The players’ specific requirements can be managed by practitioners and coaches using the running performance profile; further, it can be used to design training programs containing suitable running volumes to improve players’ performance

Betacellulin-Induced Beta Cell Proliferation and Regeneration Is Mediated by Activation of ErbB-1 and ErbB-2 Receptors

BACKGROUND: Betacellulin (BTC), a member of the epidermal growth factor family, is known to play an important role in regulating growth and differentiation of pancreatic beta cells. Growth-promoting actions of BTC are mediated by epidermal growth factor receptors (ErbBs), namely ErbB-1, ErbB-2, ErbB-3 and ErbB-4; however, the exact mechanism for beta cell proliferation has not been elucidated. Therefore, we investigated which ErbBs are involved and some molecular mechanisms by which BTC regulates beta cell proliferation. METHODOLOGY/PRINCIPAL FINDINGS: The expression of ErbB-1, ErbB-2, ErbB-3, and ErbB-4 mRNA was detected by RT-PCR in both a beta cell line (MIN-6 cells) and C57BL/6 mouse islets. Immunoprecipitation and western blotting analysis showed that BTC treatment of MIN-6 cells induced phosphorylation of only ErbB-1 and ErbB-2 among the four EGF receptors. BTC treatment resulted in DNA synthetic activity, cell cycle progression, and bromodeoxyuridine (BrdU)-positive staining. The proliferative effect was blocked by treatment with AG1478 or AG825, specific tyrosine kinase inhibitors of ErbB-1 and ErbB-2, respectively. BTC treatment increased mRNA and protein levels of insulin receptor substrate-2 (IRS-2), and this was blocked by the ErbB-1 and ErbB-2 inhibitors. Inhibition of IRS-2 by siRNA blocked cell cycle progression induced by BTC treatment. Streptozotocin-induced diabetic mice injected with a recombinant adenovirus expressing BTC and treated with AG1478 or AG825 showed reduced islet size, reduced numbers of BrdU-positive cells in the islets, and did not attain BTC-mediated remission of diabetes. CONCLUSIONS/SIGNIFICANCE: These results suggest that BTC exerts proliferative activity on beta cells through the activation of ErbB-1 and ErbB-2 receptors, which may increase IRS-2 expression, contributing to the regeneration of beta cells

Down-regulation of phospholipase D during differentiation of mouse F9 teratocarcinoma cells

AbstractPhospholipase D has been recognized as playing an important role in signal transduction in many types of cells. We investigated the expression of phospholipase D during the differentiation of F9 embryonal teratocarcinoma cells. The ADP ribosylation factor-dependent phospholipase D activity, as measured by an in vitro assay, and H2O2-induced phospholipase D activity and phospholipase D protein content in whole cells were decreased during the differentiation of F9 cells induced by a combination of dibutyryl cyclic AMP and all-trans retinoic acid. In contrast, these changes were not observed when cells were induced by retinoic acid. These results suggest that down-regulation of phospholipase D protein is associated with differentiation of F9 cells to a parietal endoderm lineage

Multidetector Computed Tomography Findings of a Papillary Fibroelastoma of the Aortic Valve: A Case Report

Papillary fibroelastoma is a rare benign cardiac tumor that represents 10% of all primary cardiac tumors. Diagnosis is accomplished incidentally by echocardiography that is usually performed for another purpose. Most papillary fibroelastomas are asymptomatic, but the lesions are recognized as a cause of embolisms. To the best of our knowledge, there has been no case report of computed tomography findings of a papillary fibroelastoma. We report a case of a papillary fibroelastoma in a 78-yr-old woman who had dyspnea and chest tightness. Echocardiography revealed a small lobulated mobile echogenic mass attached to the aortic valve, and CT demonstrated a lobulated soft tissue density mass with a thin stalk at the sinotubular junction of the aortic valve

A simple and easy home-based pulmonary rehabilitation programme for patients with Chronic Lung Diseases

Background and Aim. To develop a simple and easy home-based pulmonary rehabilitation programme and investigate its effectiveness. Methods. Patients with stable chronic lung disease were divided into a rehabilitation group (n = 25) and a control group (n = 18). Rehabilitation consisted of education and 12 weeks of enforced aerobic and musclestrengthening exercises. Aerobic exercise training was performed mostly by walking based on the functional capacity of the patients assessed by the maximal incremental exercise test. Patients visited hospital every two weeks for evaluation and a new exercise regimen. Results. Five patients dropped out of the rehabilitation group but three were due to development of unrelated diseases, five controls did not co-operate in the second evaluation. After 12 weeks of rehabilitation, exercise capacity (maximum work load and VO2max), exercise endurance, 6-minute walking distance, and quality of life measured by the St. George Respiratory Questionnaire had significantly improved in the rehabilitation group but not in the controls. At a follow-up evaluation one year after the rehabilitation, some exercise parameters were still significantly higher than baseline in the rehabilitation group. Conclusions. We developed a simple home-based pulmonary rehabilitation programme, which seems to be clinically feasible and effective

Identification of marbling-related candidate genes in M-longissimus dorsi of high- and low marbled Hanwoo (Korean native cattle) steers

This study was conducted to identify marbling-related candidate genes in M. longissimus dorsi of high- and low-marbled Hanwoo. The longissimus dorsi muscles were selected for gene expression from eight Hanwoo steer carcasses based on crude fat content. In the analysis of variance, gene expression of five candidate genes, FABP4, SCD, PPARγ, Titin and Nebulin was determined to be significantly different between high- and low-marbled Hanwoo steers (P < 0.0001). The Pik-4 and CaMK II genes were also shown to have a significant effect on crude fat content (P < 0.01). In the analysis of the differential expression between high- and low marbled groups, FABP4 gene expression was approximately 2 times higher in the high marbled group relative to the low marbled group. However, the PPAR y and SCD gene were highly expressed in the low marbled group. In addition, Titin and Nebulin were highly expressed in the low marbled group when placed under relatively high shear force. Finally, the Pik-4 and CaMKII gene also displayed a high expression pattern in the low marbled grou