Characteristics of High-Latitude Climate and Cloud Simulation in Community Atmospheric Model Version 6 (CAM6)

Many global climate models (GCMs) have difficulty in simulating climate variabilities over high northern latitudes. One of the main reasons is the inability of GCMs to simulate proper cloud fraction and the amount of liquid-containing cloud over the region. This study assessed the impact of cloud simulation in high latitudes by comparing the long-term parallel simulations of Community Atmosphere Model version 6 (CAM6) and CAM5, the previous version. The results show that the CAM6 simulation exhibits a considerable improvement in the Arctic, especially by reducing the cold bias of CAM5 throughout the year. Over the sub-Arctic region, however, CAM6 produces an excessive cold bias in summer and a warm bias in winter compared to the observation, which is closely related to the overestimation of cloud fraction and the amount of cloud liquid. In summer, the overestimation of the cloud in CAM6 tends to alleviate the cold bias compared to CAM5 due to an increase in downward longwave radiation over the high latitudes, while causing the excessive cold bias by blocking downward shortwave radiation over the sub-Arctic land area. In winter, when there is little incidence of shortwave radiation, the overestimation of the cloud in CAM6 increases the downward longwave radiation, which alleviates the cold bias in CAM5 over the Arctic but induces an excessive warm bias over the sub-Arctic land. The excessive cloudiness in CAM6 could weaken the high-latitude internal variability, exacerbating the deteriorating climate variability and long-term trend simulations in the region

Characteristics of High-Latitude Climate and Cloud Simulation in Community Atmospheric Model Version 6 (CAM6)

Many global climate models (GCMs) have difficulty in simulating climate variabilities over high northern latitudes. One of the main reasons is the inability of GCMs to simulate proper cloud fraction and the amount of liquid-containing cloud over the region. This study assessed the impact of cloud simulation in high latitudes by comparing the long-term parallel simulations of Community Atmosphere Model version 6 (CAM6) and CAM5, the previous version. The results show that the CAM6 simulation exhibits a considerable improvement in the Arctic, especially by reducing the cold bias of CAM5 throughout the year. Over the sub-Arctic region, however, CAM6 produces an excessive cold bias in summer and a warm bias in winter compared to the observation, which is closely related to the overestimation of cloud fraction and the amount of cloud liquid. In summer, the overestimation of the cloud in CAM6 tends to alleviate the cold bias compared to CAM5 due to an increase in downward longwave radiation over the high latitudes, while causing the excessive cold bias by blocking downward shortwave radiation over the sub-Arctic land area. In winter, when there is little incidence of shortwave radiation, the overestimation of the cloud in CAM6 increases the downward longwave radiation, which alleviates the cold bias in CAM5 over the Arctic but induces an excessive warm bias over the sub-Arctic land. The excessive cloudiness in CAM6 could weaken the high-latitude internal variability, exacerbating the deteriorating climate variability and long-term trend simulations in the region

Hypointense signal lesion on susceptibility-weighted imaging as a potential indicator of vertebral artery dissection in medullary infarction

Abstract Vertebral artery dissection (VAD) is often associated with medullary infarction; however, an underlying cause may be underestimated. This study aimed to assess the diagnostic potential of hypointense signal lesions along the arterial pathways using susceptibility-weighted imaging (SWI) as a feasible indicator of VAD in medullary infarction. A retrospective analysis was conducted using clinical data, brain magnetic resonance imaging, and angiography records of 79 patients diagnosed with medullary infarction between January 2014 and December 2021. Patients were categorized into an angiography-confirmed dissection group and a non-dissection group based on imaging findings. A new possible dissection group was identified using SWI, including cases with hypointense signals along the arteries without calcification or cardioembolism. We compared the clinical characteristics of the two groups before and after the addition of the hypointense signal as a marker of VAD. The angiography-confirmed dissection group included 12 patients (15%). Among patients lacking angiographic VAD evidence, 14 subjects displayed hypointense signals on SWI: nine patients along the vertebral artery and five subjects at the posterior inferior cerebellar artery without calcification or cardioembolism. The newly classified dissection group was younger, had a lower prevalence of diabetes mellitus and stroke history, and revealed increased headaches compared to the non-dissection group. Hypointense signal detection on SWI in medullary infarctions shows promise as a diagnostic indicator for VAD. Suspicion of VAD is needed when the hypointense signal on SWI is noted, and considering different treatment strategies with angiographic follow-up will be helpful

Skin-Whitening Effect of a Callus Extract of <i>Nelumbo nucifera</i> Isolate Haman

The sacred lotus (Nelumbo nucifera Gaertn. Isolate Haman, in the family Nelumbonaceae) used in this study originated from the Haman region of Korea, and lotus seeds dating back to the Goryeo Dynasty (650–760 years ago) were accidentally discovered. Lotus is known to possess antioxidant, anti-inflammatory, and soothing properties. Instead of using the lotus alone, we obtained extracts using Haman region lotus-derived callus (HLC), which allowed for a controlled, quantitative, and infinite supply. Based on the reported effects of the lotus, we formulated a hypothesis to investigate the skin-whitening effect of the HLC extract (HLCE). The HLCE was first obtained by extraction with distilled water and using 5% propanediol as a solvent and subsequently verified for the whitening effect (melanin content tests) using mammalian cells in vitro. Its efficacy at the molecular level was confirmed through real-time polymerase chain reaction (PCR) using melanin-related genes. Furthermore, clinical trials with 21 volunteers confirmed the significant whitening effect of cosmetics containing the HLCE. In conclusion, we found that the HLCE not only has anti-inflammatory, antioxidant, and skin-soothing properties but also plays an essential role in skin whitening. Therefore, we propose that the HLCE has the potential to become a new raw material for the cosmetic industry