6 research outputs found
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Effects of Metformin on Spatial and Verbal Memory in Children with ASD and Overweight Associated with Atypical Antipsychotic Use
- Author
- Publication venue
- 'Mary Ann Liebert Inc'
- Publication date
- 27/06/2018
- Field of study
Abstract Objectives: Studies in humans and rodents suggest that metformin, a medicine typically used to treat type 2 diabetes, may have beneficial effects on memory. We sought to determine whether metformin improved spatial or verbal memory in children with autism spectrum disorder (ASD) and overweight associated with atypical antipsychotic use. Methods: We studied the effects of metformin (Riomet®) concentrate on spatial and verbal memory in 51 youth with ASD, ages 6 through 17 years, who were taking atypical antipsychotic medications, had gained significant weight, and were enrolled in a trial of metformin for weight management. Phase 1 was a 16-week, randomized, double-blind, placebo-controlled, parallel-group comparison of metformin (500–850 mg given twice a day) versus placebo. During Phase 2, all participants took open-label metformin from week 17 through week 32. We assessed spatial and verbal memory using the Neuropsychological Assessment 2nd Edition (NEPSY–II) and a modified children's verbal learning task. Results: No measures differed between participants randomized to metformin versus placebo, at either 16 or 32 weeks, after adjustment for multiple comparisons. Sixteen-week change in memory for spatial location on the NEPSY–II was nominally better among participants randomized to placebo. However, patterns of treatment response across all measures revealed no systematic differences in performance, suggesting that metformin had no effect on spatial or verbal memory in these children. Conclusions: Although further study is needed to support these null effects, the overall impression is that metformin does not affect memory in overweight youth with ASD who were taking atypical antipsychotic medications
Effects of Metformin on Spatial and Verbal Memory in Children with ASD and Overweight Associated with Atypical Antipsychotic Use
- Author
- Publication venue
- 'Mary Ann Liebert Inc'
- Publication date
- Field of study
Development and application of the concept of user image: The case of mass transit ridership
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The Whore of Babylon Metaphor
- Author
- Bell Shannon
- Bird Phyllis A.
- Boring Eugene M.
- Boyarin Daniel
- Collins Adela Yarbro
- Countryman L. William
- Day Peggy L.
- Fiorenza Elisabeth Schussler
- Fiorenza Elisabeth Schussler
- Fiorenza Elisabeth Schussler
- Frymer-Kensky Tikva
- Goldsmith Steven
- Guider Margaret Eletta
- Harrison Beverly
- Keller Catherine
- Kittel Gerhard
- Kraemer Ross Shepard
- Metzger Bruce
- Mydans Seth
- Newsom Carol A.
- Pippin Tina
- Pomeroy Sarah B.
- Pomeroy Sarah B.
- Richard Pablo
- Rienecker Fritz
- Roberts Nickie
- Rousselle Aline
- Rowland Christopher
- Salisbury Joyce E.
- Schaberg Jane
- Schottroff Luise
- Swete Henry Barclay
- Talbert Charles H.
- Thompson Leonard L.
- Truong Thanh-Dam
- Veyne Paul
- Westcott Brooke Foss
- Williams Delores S.
- Zatz Noah D.
- Publication venue
- 'The Haworth Press'
- Publication date
- Field of study
Historic preservation: A comparative analyses
- Author
- Alan Axelrod
- Albert Hunter
- Alfred Runte
- Ann Douglas
- Ann MacEwen
- Arthur Vidich
- Barry Schwartz
- C. Wright Mills
- Charles B. Hosmer Jr.
- Charles Dellheim
- Craig Jackson Calhoun
- César Graña
- D. M. Matheson
- David Lowenthal
- David Shi
- Diane Barthel
- Diane Barthel
- Edward Shils
- Eugene Rochberg-Halton
- Fiona MacCarthy
- Geoffrey Scott
- Gerald Suttles
- Gilbert Durand
- Henry Nash Smith
- Herbert Gans
- Hervé Varenne
- Jacques Donzelot
- James Marston Fitch
- Janet Wolff
- John Brinckerhoff Jackson
- John Ruskin
- Joshua C. Taylor
- Kenneth Burke
- Michael DeHaven Newsom
- Mihaly Csikszentmihalyi
- National Trust for Historic Preservation
- National Trust for Historic Preservation
- Patrick Wright
- Paul DiMaggio
- Paul Thompson
- Peter Maris
- Pierre Bourdieu
- Raymond Williams
- Raymond Williams
- Richard Hofstadter
- Robert H. Wiebe
- Robin Fedden
- Roland Barthes
- Samuel Hays
- T. J. Jackson Lears
- Walter Karp
- Walter Karp
- William Butler
- William Cobbett
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
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- 'Vandenhoeck & Ruprecht GmbH & Co, KG'
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