Future Challenges in Psychotherapy Research for Personality Disorders

Purpose of Review Individuals with personality disorders are frequently seen in mental health settings. Their symptoms typically reflect a high level of suffering and burden of disease, with potentially harmful societal consequences, including costs related to absenteeism at work, high use of health services, ineffective or harmful parenting, substance use, suicidal and non-suicidal self-harming behavior, and aggressiveness with legal consequences. Psychotherapy is currently the first-line treatment for patients with personality disorders, but the study of psychotherapy in the domain of personality disorders faces specific challenges. Recent Findings Challenges include knowing what works for whom, identifying which putative mechanisms of change explain therapeutic effects, and including the social interaction context of patients with a personality disorder. By following a dimensional approach, psychotherapy research on personality disorders may serve as a model for the development and study of innovative psychotherapeutic interventions. Summary We recommend developing the following: (a) an evidence base to make treatment decisions based on individual features; (b) a data-driven approach to predictors, moderators, and mechanisms of change in psychotherapy; (c) methods for studying the interaction between social context and psychotherapy

Beyond mystery: Putting algorithmic accountability in context

Critical algorithm scholarship has demonstrated the difficulties of attributing accountability for the actions and effects of algorithmic systems. In this commentary, we argue that we cannot stop at denouncing the lack of accountability for algorithms and their effects but must engage the broader systems and distributed agencies that algorithmic systems exist within; including standards, regulations, technologies, and social relations. To this end, we explore accountability in “the Generated Detective,” an algorithmically generated comic. Taking up the mantle of detectives ourselves, we investigate accountability in relation to this piece of experimental fiction. We problematize efforts to effect accountability through transparency by undertaking a simple operation: asking for permission to re-publish a set of the algorithmically selected and modified words and images which make the frames of the comic. Recounting this process, we demonstrate slippage between the “complication” of the algorithm and the obscurity of the legal and institutional structures in which it exists

Reconstruction of a scalar-tensor theory of gravity in an accelerating universe

The present acceleration of the Universe strongly indicated by recent observational data can be modeled in the scope of a scalar-tensor theory of gravity. We show that it is possible to determine the structure of this theory (the scalar field potential and the functional form of the scalar-gravity coupling) along with the present density of dustlike matter from the following two observable cosmological functions: the luminosity distance and the linear density perturbation in the dustlike matter component as functions of redshift. Explicit results are presented in the first order in the small inverse Brans-Dicke parameter 1/omega.Comment: 4 pages, LaTeX 2.09, REVTeX 3.0, two-column forma

Astrometric and Timing Effects of Gravitational Waves from Localized Sources

A consistent approach for an exhaustive solution of the problem of propagation of light rays in the field of gravitational waves emitted by a localized source of gravitational radiation is developed in the first post-Minkowskian and quadrupole approximation of General Relativity. We demonstrate that the equations of light propagation in the retarded gravitational field of an arbitrary localized source emitting quadrupolar gravitational waves can be integrated exactly. The influence of the gravitational field on the light propagation is examined not only in the wave zone but also in cases when light passes through the intermediate and near zones of the source. Explicit analytic expressions for light deflection and integrated time delay (Shapiro effect) are obtained accounting for all possible retardation effects and arbitrary relative locations of the source of gravitational waves, that of light rays, and the observer. It is shown that the ADM and harmonic gauge conditions can both be satisfied simultaneously outside the source of gravitational waves. Their use drastically simplifies the integration of light propagation equations and those for the motion of light source and observer in the field of the source of gravitational waves, leading to the unique interpretation of observable effects. The two limiting cases of small and large values of impact parameter are elaborated in more detail. Explicit expressions for Shapiro effect and deflection angle are obtained in terms of the transverse-traceless part of the space-space components of the metric tensor. We also discuss the relevance of the developed formalism for interpretation of radio interferometric and timing observations, as well as for data processing algorithms for future gravitational wave detectors.Comment: 43 pages, 4 Postscript figures, uses revtex.sty, accepted to Phys. Rev. D, minor corrections in formulae regarding algebraic sign

Bioremoval of diethylketone by the synergistic combination of microorganisms and clays : uptake, removal and kinetic studies

The performance of two bacteria, Arthrobacter viscosus and Streptococcus equisimilis, and the effect of the interaction of these bacteria with four different clays on the retention of diethylketone were investigated in batch experiments. The uptake, the removal percentages and the kinetics of the processes were determined. S. equisimilis,by itself, had the best performance in terms of removal percentage, for all the initial diethylketone concentrations tested: 200, 350 and 700 mg/L. The uptake values are similar for both bacteria. A possible mechanism to explain the removal of diethylketone includes its degradation by bacteria, followed by the adsorption of the intermediates/sub-products by the functional groups present on the cells surfaces. The assays performed with bacteria and clays indicated that the uptake values are similar despite of the clay used, for the same microorganism and mass of clay, but in general higher values are reached when S. equisimilis is used, compared to A. viscosus. Kinetic data were described by pseudo-first and pseudo-second order models.The authors would like to gratefully acknowledge the financial support of this project by the Fundacao para a Ciencia e Tecnologia, Ministerio da Ciencia e Tecnologia, Portugal and co-funding by FSE (programme QREN-POPH). Cristina Quintelas thanks FCT for a post-doc grant. The authors would like also to thank Minas de Barqueiros, S. A., Prof. Rui Boaventura (FEUP-Portugal) and Prof. Isabel Correia Neves (Dep Quimica, UM, Portugal) who gently offered the clays

Salinity management options for the Colorado River. Damage estimates and control program impacts

Rivers draining arid basins increase in salinity content in the downstream area to the point where water users are often significantly damaged. The problem in some cases can be ameliorated by altering upstream water and land use practices. An economic trade off exists between the cost of such upstream efforts and the downstream benefits achieved. This report examines options for salinity management in the Colorado River Basin. The study sought to provide additional information to estimate 1) economic damages caused by various salt concentrations to agricultural and municipal water users and 2) economic costs of salinity control measures by upstream water users. Damages were estimated for high salinity levels to provide guidelines to project future conditions. Control costs were estimated with a physical model developed to predict the response of soil, water, and crop factors. Input-output models were used to estimate indirect economic impacts. Agricultural damages for each milligram per liter of salt concentration at Imperial Dam in the 900 to 1400 range were estimated to be #33,100 annually. Of the total, $28,200 are in the Imperial Valley and decreasing g amounts occur respectively in the Palo Verde, Yuma, Colorado River Indian Reservation, Sand Diego, Coachella, and Central Arizona and$11,400 for the $112,000 per mg/1. Comparable estimates were$11,200 for Central Arizona and $11,400 for the Las Vegas area. As for controlled costs, 80 percent of the initial salt load could theoretically be at an incremental cost of less than$2.20 per ton. The comparison of the reduction measures showed on-farm practices to be the last expensive alternative for reducing salinity. Based on an approximation that 1 mg/1 at Imperial Dam is equivalent to 10,000 tons of salt, the above estimated benefits of salinity reduction would be about $17 per ton. Salinity control projects at Paradox Valley and acreage retirements in the Grand and Uncompaghre Valleys were found to be economically justified but lining the Grand Valley Canal was not. The above estimates are approximations obtained from available data and can be improved by further studies to cover additional cost and benefit effects or by more comprehensive data the effects covered

TRPV1 enhances the afferent response to P2X receptor activation in the mouse urinary bladder

Both TRPV1 and P2X receptors present on bladder sensory nerve fibres have been implicated in mechanosensation during bladder filling. The aim of this study was to determine possible interactions between these receptors in modulating afferent nerve activity. In wildtype (TRPV1+/+) and TRPV1 knockout (TRPV1−/−) mice, bladder afferent nerve activity, intravesical pressure, and luminal ATP and acetylcholine levels were determined and also intracellular calcium responses of dissociated pelvic DRG neurones and primary mouse urothelial cells (PMUCs). Bladder afferent nerve responses to the purinergic agonist αβMethylene-ATP were depressed in TRPV1−/− mice (p ≤ 0.001) and also in TRPV1+/+ mice treated with the TRPV1-antagonist capsazepine (10 µM; p ≤ 0.001). These effects were independent of changes in bladder compliance or contractility. Responses of DRG neuron to αβMethylene-ATP (30 µM) were unchanged in the TRPV1−/− mice, but the proportion of responsive neurones was reduced (p ≤ 0.01). Although the TRPV1 agonist capsaicin (1 µM) did not evoke intracellular responses in PMUCs from TRPV1+/+ mice, luminal ATP levels were reduced in the TRPV1−/− mice (p ≤ 0.001) compared to wildtype. TRPV1 modulates P2X mediated afferent responses and provides a mechanistic basis for the decrease in sensory symptoms observed following resiniferatoxin and capsaicin treatment for lower urinary tract symptoms

Robotics and automation in the city: a research agenda

Globally cities are becoming experimental sites for new forms of robotic and automation technologies applied across a wide variety of sectors in multiple areas of economic and social life. As these innovations leave the laboratory and factory, this paper analyses how robotics and automation systems are being layered upon existing urban digital networks, extending the capabilities and capacities of human agency and infrastructure networks, and reshaping the city and citizen’s everyday experiences. To date, most work in this field has been speculative and isolated in nature. We set out a research agenda that goes beyond analysis of discrete applications and effects, to investigate how robotics and automation connect across urban domains and the implications for: differential urban geographies, the selective enhancement of individuals and collective management of infrastructures, the socio-spatial sorting of cities and the potential for responsible urban innovation

Recovering critique in an age of datafication

This article starts out from the need for critical work on processes of datafication and their consequences for the constitution of social knowledge and the social world. Current social science work on datafication has been greatly shaped by the theoretical approach of Bruno Latour, as reflected in the work of Actor Network Theory and Science and Technology Studies (ANT/STS). The article asks whether this approach, given its philosophical underpinnings, provides sufficient resources for the critical work that is required in relation to datafication. Drawing on Latour’s own reflections about the flatness of the social, it concludes that it does not, since key questions, in particular about the nature of social order cannot be asked or answered within ANT. In the article’s final section, three approaches from earlier social theory are considered as possible supplements to ANT/STS for a social science serious about addressing the challenges that datafication poses for society

Inhibition of SOC/Ca2+/NFAT pathway is involved in the anti-proliferative effect of sildenafil on pulmonary artery smooth muscle cells

<p>Abstract</p> <p>Background</p> <p>Sildenafil, a potent phosphodiesterase type 5 (PDE5) inhibitor, has been proposed as a treatment for pulmonary arterial hypertension (PAH). The mechanism of its anti-proliferative effect on pulmonary artery smooth muscle cells (PASMC) is unclear. Nuclear translocation of nuclear factor of activated T-cells (NFAT) is thought to be involved in PASMC proliferation and PAH. Increase in cytosolic free [Ca²⁺] ([Ca²⁺]_i) is a prerequisite for NFAT nuclear translocation. Elevated [Ca²⁺]_iin PASMC of PAH patients has been demonstrated through up-regulation of store-operated Ca²⁺channels (SOC) which is encoded by the transient receptor potential (TRP) channel protein. Thus we investigated if: 1) up-regulation of TRPC1 channel expression which induces enhancement of SOC-mediated Ca²⁺influx and increase in [Ca²⁺]_iis involved in hypoxia-induced PASMC proliferation; 2) hypoxia-induced promotion of [Ca²⁺]_ileads to nuclear translocation of NFAT and regulates PASMC proliferation and TRPC1 expression; 3) the anti-proliferative effect of sildenafil is mediated by inhibition of this SOC/Ca²⁺/NFAT pathway.</p> <p>Methods</p> <p>Human PASMC were cultured under hypoxia (3% O₂) with or without sildenafil treatment for 72 h. Cell number and cell viability were determined with a hemocytometer and MTT assay respectively. [Ca²⁺]_iwas measured with a dynamic digital Ca²⁺imaging system by loading PASMC with fura 2-AM. TRPC1 mRNA and protein level were detected by RT-PCR and Western blotting respectively. Nuclear translocation of NFAT was determined by immunofluoresence microscopy.</p> <p>Results</p> <p>Hypoxia induced PASMC proliferation with increases in basal [Ca²⁺]_iand Ca²⁺entry via SOC (SOCE). These were accompanied by up-regulation of TRPC1 gene and protein expression in PASMC. NFAT nuclear translocation was significantly enhanced by hypoxia, which was dependent on SOCE and sensitive to SOC inhibitor SKF96365 (SKF), as well as cGMP analogue, 8-brom-cGMP. Hypoxia-induced PASMC proliferation and TRPC1 up-regulation were inhibited by SKF and NFAT blocker (VIVIT and Cyclosporin A). Sildenafil treatment ameliorated hypoxia-induced PASMC proliferation and attenuated hypoxia-induced enhancement of basal [Ca²⁺]_i, SOCE, up-regulation of TRPC1 expression, and NFAT nuclear translocation.</p> <p>Conclusion</p> <p>The SOC/Ca²⁺/NFAT pathway is, at least in part, a downstream mediator for the anti-proliferative effect of sildenafil, and may have therapeutic potential for PAH treatment.</p