An introduction to the multidimensional real-time economic modeling

This article proposes a new economic modeling theoretical framework known as multidimensional real-time economic modeling (MRTE-Modeling). The model is an important tool that economists and educators can use to demonstrate the multidimensional aspects of economic behavior. MRTE-Modeling facilitates the analysis of a series of complex and dynamic economic problems that can affect market behavior from a multidimensional perspective. The proposed MRTE-Modeling framework is based on the uses of an alternative mathematical modeling framework, multidimensional graphical modeling approach, and computer algorithm and, thus, allows the possibility to transition from 2-dimensional economic dynamic modeling to multidimensional real-time economic modeling. Therefore, the main objective of using the proposed experimental model in the field of economics is to analyze different macroeconomic scenarios to monitor and provide a warning of possible unexpected economic failure(s). The proposed alternative experimental model is based on the application of Econographicology. Hence, our model is expected to offer policy makers and researchers new analytical tools to study the impact and trend of economic failures in the economy of any country from a new perspective

QSAR study and molecular design of open-chain enaminones as anticonvulsant agents

Present work employs the QSAR formalism to predict the ED50 anticonvulsant activity of ringed-enaminones, in order to apply these relationships for the prediction of unknown open-chain compounds containing the same types of functional groups in their molecular structure. Two different modeling approaches are applied with the purpose of comparing the consistency of our results: (a) the search of molecular descriptors via multivariable linear regressions; and (b) the calculation of flexible descriptors with the CORAL (CORrelation And Logic) program. Among the results found, we propose some potent candidate open-chain enaminones having ED50 values lower than 10 mg·kg-1 for corresponding pharmacological studies. These compounds are classified as Class 1 and Class 2 according to the Anticonvulsant Selection Project.Instituto de Investigaciones Fisicoquímicas Teóricas y AplicadasFacultad de Ciencias Exacta

Macrófitasde la cuenca del río Elqui, zona semiárida de Chile

Background and aims: The Elqui river basin is located north of the Coquimbo Region, in the semiarid zone of Chile. This body of water is particularly important due to the economic activities it supports and its high environmental vulnerability. The objective of this study was to determine the diversity and composition of the macrophyte flora of the Elqui river basin.M&M: Twenty sampling stations with plots of 1 m2were distributed in the three sub-basins that make up the study area. Inside each plot, all plant species were recorded along with their respective abundances. In addition, in each station some environmental variables were measured, which were analyzed together with the biological data.Results: A total of 51 macrophyte species and one alga were identified, with dominance of native elements with emergent habit. Statistical analyses indicate moderate differences regarding the floristic composition of the three sub-basins compared, these are mainly concentrated in the Turbio river. The analysis of the environmental data indicates that the variables that most influence the composition of species in the study area are: altitude, total suspended solids, redox potential and water depth.Discussion: Studies on macrophytes at the hydrographic basin level are practically null in Chile. This type of information increases knowledge on biodiversity andallows a more efficient management of continental aquatic systems.Introducción y objetivos: La cuenca del río Elqui está situada al norte de la Región de Coquimbo, en la zona semiárida de Chile. Este cuerpo de agua es particularmente importante por las actividades económicas que sustenta y por su alta vulnerabilidad ambiental. El objetivo del presente estudio fue determinar la diversidad y composición florística de macrófitas de la cuenca del río Elqui.M&M: Se establecieron 20 estaciones de muestreo con parcelas de 1 m2 distribuidas en las tres subcuencas que conforman el área de estudio. Al interior de cada una de ellas, se registraron todas las especies de plantas presentes junto a sus respectivas abundancias. Además, en cada estación se midieron algunas variables ambientales, las que fueron analizadas junto con los datos biológicos.Resultados: Se identificaron 51 especies de macrófitas y un alga, con dominancia de elementos nativos y de hábito emergente. Los análisis estadísticos señalan leves diferencias en cuanto a la composición florística que presentan las tres subcuencas comparadas, las cuales se concentran principalmente en el río Turbio.El análisis de los datos ambientales señala que las variables que más influyen en la composición de especies del área de estudio son: altitud, sólidos suspendidos totales, potencial redox y profundidad del agua.Discusión: Los estudios relativos a macrófitas a nivel de cuenca hidrográfica son prácticamente nulos en Chile. Este tipo de información incrementa el conocimiento de la biodiversidad y permite realizar un manejo más eficiente de los sistemas acuáticos continentales

Post-Traumatic Stress Associated with Telework-Related Job Limitation in Latin America

During the pandemic, there has been evidence of work limitations during telework, which are believed to cause mental health problems. Our objective was to assess the association between perceived work limitations during telework and posttraumatic stress during the COVID-19 pandemic in Latin America. A cross-sectional study was conducted in Latin America in 2020. Exposure was measured by self-reporting using a self-perception questionnaire; the SPRINT-E questionnaire was used for outcome measurements. Generalized linear models were applied. Of 1329 participants, 15.2% (n = 202) had posttraumatic stress. In a multivariate analysis, the highest frequency of posttraumatic stress was found among those with moderate depression or more (PR = 1.29; 95% CI: 1.03–1.61), moderate or more anxiety (PR = 2.34; 95% CI: 1.61–3.41), and moderate or more stress (PR = 2.45; 95% CI: 1.46–4.12). In conclusion, there is an association between perceived work limitations during telework and posttraumatic stress in Latin American workers. For this reason, it is recommended that occupational physicians, companies, and institutions assess the frequency of posttraumatic stress and monitor the mental health of workers.National Institute of Mental HealthRevisión por pare

QSAR study and molecular design of open-chain enaminones as anticonvulsant agents

Present work employs the QSAR formalism to predict the ED50 anticonvulsant activity of ringed-enaminones, in order to apply these relationships for the prediction of unknown open-chain compounds containing the same types of functional groups in their molecular structure. Two different modeling approaches are applied with the purpose of comparing the consistency of our results: (a) the search of molecular descriptors via multivariable linear regressions; and (b) the calculation of flexible descriptors with the CORAL (CORrelation And Logic) program. Among the results found, we propose some potent candidate open-chain enaminones having ED50 values lower than 10 mg·kg-1 for corresponding pharmacological studies. These compounds are classified as Class 1 and Class 2 according to the Anticonvulsant Selection Project.Instituto de Investigaciones Fisicoquímicas Teóricas y AplicadasFacultad de Ciencias Exacta

Computational chemical analysis of unconjugated bilirubin anions and insights into pKa values clarification

The pKa, the negative logarithm of the acid dissociation equilibrium constant, of the carboxylic acid groups of unconjugated bilirubin in water is a discussed issue because there are quite different experimental values reported. Using quantum mechanical calculations we have studied the conformational behavior of unconjugated bilirubin species (in gas phase and in solution modeled implicitly and explicitly) to provide evidence that may clarify pKa values because of its pathophysiological relevance. Our results show that rotation of carboxylate group, which is not restricted, settles it in a suitable place to establish stronger interactions that stabilizes the monoanion and the dianion to be properly solvated, demonstrating that the rationalization used to justify the high pKa values of unconjugated bilirubin is inappropriate. Furthermore, low unconjugated bilirubin (UCB) pKa values were estimated from a linear regression analysis.Fil: Vega Hissi, Esteban Gabriel. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Quimica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Estrada, Mario Rinaldo. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Quimica; ArgentinaFil: Lavecchia, Martín José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Centro de Química Inorgánica; ArgentinaFil: Pis Diez, Reinaldo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Centro de Química Inorgánica; Argentin

Estudio farmacognósico para el cuidado de la salud a partir de aceites esenciales obtenidos por destilación de arrastre de vapor

La medicina natural aborda de forma considerable el conocimiento etnobotánico de las plantas medicinales a partir del estudio de sus principios activos, mediante técnicas de fotoquímica en la aplicación de los diferentes campos de la salud. La producción de plantas medicinales y aromáticas resulta rentable cuando se le da un valor agregado a la producción primaria, es decir, se comercializan no como drogas vegetales frescas o secas, sino procesadas y transformadas de donde se obtienen extractos, aceites o pueden elaborarse fitomedicamentos, fitocosméticos, etc. Se realizó un estudio con abordaje experimental, donde se tomó como referente algunas especies del género Ocimum pertenecientes a la familia Labiatae (Lamiaceae) cultivadas en el departamento de Risaralda