Sensitization to isothiazolinones in the Spanish Contact Dermatitis Registry (REIDAC): 2019–2021 epidemiological situation

Background: Current frequency and risk factors for sensitization to methylisothiazolinone (MI), methylchloroisothiazolinone/methylisothiazolinone (MCI/MI), benzisothiazolinone (BIT) and octylisothiazolinone (OIT) in Spain are not well known. Objectives: To study the frequency of sensitization, risk factors and simultaneous sensitization between the four isothiazolinones. Materials and Methods: We analysed all 2019-2021 consecutive patients patch-tested with MI (0.2% aq.), MCI/MI (0.02% aq.), BIT (0.1% pet.) and OIT (0.1% pet) within the Spanish Contact Dermatitis Registry (REIDAC). Results: A total of 2511 patients were analysed. Frequencies of sensitization were: any isothiazolinone 15.7%, MI 6.8%, MCI/MI 4.8%, BIT 3.5% and OIT 0.5%. MI and MCI/MI sensitization was associated with being occupationally active, hand dermatitis, detergents and age over 40. BIT sensitization was associated with leg dermatitis and age over 40. About one in nine MI-positive patients were positive to BIT, whereas one in five BIT-positive patients were positive to MI. Conclusions: Sensitization to MI, MCI/MI and BIT is still common in Spain, while sensitization to OIT is rare. Currently, sensitization to MI and MCI/MI seems to be occupationally related. Although its origin is unknown, sensitization to BIT is more frequent in patients aged over 40 years. Simultaneous sensitization between MI and BIT is uncommon.The Spanish Registry of Contact Dermatitis (REIDAC) is promoted by the Fundación Piel Sana (Academia Española de Dermatología y Venereología), which has received financial support from the Spanish Medicines and Health Products Agency (Agencia Española de Medicamentos y Productos Sanitarios. https://www.boe.es/boe/dias/2022/04/11/pdfs/BOE-A-2022-5975.pdf) and Sanofi. The funders were not involved in the design and conduct of the study, collection, management, analysis and interpretation of data, preparation, review, approval of the manuscript, or decision to submit the manuscript for publication

Relaciones interculturales, mercado de trabajo y localización socio-espacial de los inmigrantes bolivianos que residen en áreas urbanas y periurbanas de la ciudad de Córdoba

Este proyecto estudiará los procesos de segmentación del mercado laboral y de segregación socio-espacial de los inmigrantes bolivianos en áreas urbanas y peri-urbanas de la ciudad de Córdoba, y las maneras en que dichos procesos son justificados a través de estereotipos basados en distinciones culturales y/o raciales. Focalizaremos sobre las relaciones de desigualdad y de explotación que signan el mercado de trabajo y otros espacios de sociabilidad en el contexto actual de acumulación del capital. Nos planteamos las siguientes hipótesis: 1) Los inmigrantes bolivianos que residen en la ciudad de Córdoba se vinculan, como mano de obra no calificada, con un mercado laboral informal segmentado étnicamente, en el marco de procesos discriminatorios basados en estereotipos étnico-raciales. 2) Algunos inmigrantes bolivianos lograron cierta movilidad económicoproductiva, convirtiéndose en patrones de sus co-nacionales en diferentes sectores (construcción, horticultura, comercio informal, industria de indumentaria), hecho que es facilitado por la activación de redes migratorias. 3) Los estereotipos sobre los bolivianos son re-significados y, a veces, confrontados por agentes vinculados con los medios y con organismos gubernamentales y no gubernamentales. 4) La segregación residencial es otro mecanismo discriminatorio que favorece la exclusión de los inmigrantes trabajadores. Nuestro objetivo principal es caracterizar los diferentes ámbitos laborales en los que se desempeñan los inmigrantes bolivianos en la ciudad de Córdoba y conceptualizar las relaciones inter e intra culturales que se dan en ese marco, teniendo en cuenta la incidencia de: las redes migratorias, las trayectorias migratorias y laborales, y la heterogeneidad de los capitales de los inmigrantes; la localización socio-espacial de los lugares de trabajo y de otros espacios de sociabilidad; y, las maneras en que diversos agentes reproducen o confrontan los estereotipos sobre los bolivianos. Se aplicará una estrategia de triangulación de métodos y de técnicas. Desde un enfoque cuantitativo analizaremos los aspectos socio-demográficos de la población de origen boliviano que reside en la ciudad de Córdoba, teniendo en cuenta su inserción laboral y ubicación socio-espacial en áreas urbanas y peri-urbanas. Se analizarán periódicos de edición provincial y aquellos editados por organizaciones de inmigrantes bolivianos en Córdoba y en Buenos Aires. Se caracterizarán las acciones y políticas destinadas a inmigrantes bolivianos. Se realizarán estudios etnográficos de casos en las áreas urbanas y peri-urbanas en donde residen y/o trabajan inmigrantes bolivianos. Se desarrollarán talleres destinados a inmigrantes bolivianos con el objetivo de reflexionar sobre sus derechos laborales y sus derechos como inmigrantes.Fil: Pizarro, Cynthia Alejandra. Universidad Católica de Córdoba. Facultad de Ciencia Política y Relaciones Internacionales; ArgentinaFil: Fontana, Silvia Esther. Universidad Católica de Córdoba. Facultad de Ciencia Política y Relaciones Internacionales; ArgentinaFil: Conrero, Sofía. Universidad Católica de Córdoba. Facultad de Ciencia Política y Relaciones Internacionales; ArgentinaFil: Universidad Católica de Córdoba; Argentina

Natural History of MYH7-Related Dilated Cardiomyopathy

BACKGROUND Variants in myosin heavy chain 7 (MYH7) are responsible for disease in 1% to 5% of patients with dilated cardiomyopathy (DCM); however, the clinical characteristics and natural history of MYH7-related DCM are poorly described. OBJECTIVES We sought to determine the phenotype and prognosis of MYH7-related DCM. We also evaluated the influence of variant location on phenotypic expression. METHODS We studied clinical data from 147 individuals with DCM-causing MYH7 variants (47.6% female; 35.6 +/- 19.2 years) recruited from 29 international centers. RESULTS At initial evaluation, 106 (72.1%) patients had DCM (left ventricular ejection fraction: 34.5% +/- 11.7%). Median follow-up was 4.5 years (IQR: 1.7-8.0 years), and 23.7% of carriers who were initially phenotype-negative developed DCM. Phenotypic expression by 40 and 60 years was 46% and 88%, respectively, with 18 patients (16%) first diagnosed at <18 years of age. Thirty-six percent of patients with DCM met imaging criteria for LV noncompaction. During follow-up, 28% showed left ventricular reverse remodeling. Incidence of adverse cardiac events among patients with DCM at 5 years was 11.6%, with 5 (4.6%) deaths caused by end-stage heart failure (ESHF) and 5 patients (4.6%) requiring heart transplantation. The major ventricular arrhythmia rate was low (1.0% and 2.1% at 5 years in patients with DCM and in those with LVEF of <= 35%, respectively). ESHF and major ventricular arrhythmia were significantly lower compared with LMNA-related DCM and similar to DCM caused by TTN truncating variants. CONCLUSIONS MYH7-related DCM is characterized by early age of onset, high phenotypic expression, low left ventricular reverse remodeling, and frequent progression to ESHF. Heart failure complications predominate over ventricular arrhythmias, which are rare. (C) 2022 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation

Spread of a SARS-CoV-2 variant through Europe in the summer of 2020

[EN] Following its emergence in late 2019, the spread of SARS-CoV-21,2 has been tracked by phylogenetic analysis of viral genome sequences in unprecedented detail3,4,5. Although the virus spread globally in early 2020 before borders closed, intercontinental travel has since been greatly reduced. However, travel within Europe resumed in the summer of 2020. Here we report on a SARS-CoV-2 variant, 20E (EU1), that was identified in Spain in early summer 2020 and subsequently spread across Europe. We find no evidence that this variant has increased transmissibility, but instead demonstrate how rising incidence in Spain, resumption of travel, and lack of effective screening and containment may explain the variant’s success. Despite travel restrictions, we estimate that 20E (EU1) was introduced hundreds of times to European countries by summertime travellers, which is likely to have undermined local efforts to minimize infection with SARS-CoV-2. Our results illustrate how a variant can rapidly become dominant even in the absence of a substantial transmission advantage in favourable epidemiological settings. Genomic surveillance is critical for understanding how travel can affect transmission of SARS-CoV-2, and thus for informing future containment strategies as travel resumes.S

Gestión del conocimiento: perspectiva multidisciplinaria. Volumen 12

El libro “Gestión del Conocimiento. Perspectiva Multidisciplinaria”, Volumen 12, de la Colección Unión Global, es resultado de investigaciones. Los capítulos del libro, son resultados de investigaciones desarrolladas por sus autores. El libro cuenta con el apoyo de los grupos de investigación: Universidad Sur del Lago “Jesús María Semprúm” (UNESUR), Zulia – Venezuela; Universidad Politécnica Territorial de Falcón Alonso Gamero (UPTAG), Falcón – Venezuela; Universidad Politécnica Territorial de Mérida Kleber Ramírez (UPTM), Mérida – Venezuela; Universidad Guanajuato (UG) - Campus Celaya - Salvatierra - Cuerpo Académico de Biodesarrollo y Bioeconomía en las Organizaciones y Políticas Públicas (C.A.B.B.O.P.P), Guanajuato – México; Centro de Altos Estudios de Venezuela (CEALEVE), Zulia – Venezuela, Centro Integral de Formación Educativa Especializada del Sur (CIFE - SUR) - Zulia - Venezuela, Centro de Investigaciones Internacionales SAS (CIN), Antioquia - Colombia.y diferentes grupos de investigación del ámbito nacional e internacional que hoy se unen para estrechar vínculos investigativos, para que sus aportes científicos formen parte de los libros que se publiquen en formatos digital e impreso

Gestión del conocimiento. Perspectiva multidisciplinaria. Volumen 17

El libro “Gestión del Conocimiento. Perspectiva Multidisciplinaria”, Volumen 17 de la Colección Unión Global, es resultado de investigaciones. Los capítulos del libro, son resultados de investigaciones desarrolladas por sus autores. El libro es una publicación internacional, seriada, continua, arbitrada, de acceso abierto a todas las áreas del conocimiento, orientada a contribuir con procesos de gestión del conocimiento científico, tecnológico y humanístico. Con esta colección, se aspira contribuir con el cultivo, la comprensión, la recopilación y la apropiación social del conocimiento en cuanto a patrimonio intangible de la humanidad, con el propósito de hacer aportes con la transformación de las relaciones socioculturales que sustentan la construcción social de los saberes y su reconocimiento como bien público

Relationship between Amount, Type, Enjoyment of Physical Activity and Physical Education Performance with Cyberbullying in Adolescents

(1) Background: Cyberbullying is a social concern in adolescents. The practice of physical activity is a key factor in protection against cyberbullying related to the multiple psychological benefits. Therefore, the study sets out to analyse the relationship between amount, types, enjoyment of physical activity and performance in physical education with cyberbullying. (2) Methods: A sample of 867 adolescents between 12 and 19 years of age from two schools in Andalusia (Spain) was studied. A computer-based questionnaire given in the classroom was used, with two questions about the type of physical activity, one on physical education performance, the Scale of Enjoyment of Physical Activity (PACES) and the Spanish version of the European Cyberbullying Intervention Project Questionnaire (ECIPQ). (3) Results: Clear relationships were found between the practice of physical activity and cybervictimisation. However, less involvement has been observed among girls who practice physical activity in cyberaggression. (4) Conclusions: In relation to the types of physical activity, it seems that practising physical activities that involve competition can help to develop defence mechanisms against cyberaggression, as well as improve values to be less involved in cyberaggression

Relationship between Amount, Type, Enjoyment of Physical Activity and Physical Education Performance with Cyberbullying in Adolescents

(1) Background: Cyberbullying is a social concern in adolescents. The practice of physical activity is a key factor in protection against cyberbullying related to the multiple psychological benefits. Therefore, the study sets out to analyse the relationship between amount, types, enjoyment of physical activity and performance in physical education with cyberbullying. (2) Methods: A sample of 867 adolescents between 12 and 19 years of age from two schools in Andalusia (Spain) was studied. A computer-based questionnaire given in the classroom was used, with two questions about the type of physical activity, one on physical education performance, the Scale of Enjoyment of Physical Activity (PACES) and the Spanish version of the European Cyberbullying Intervention Project Questionnaire (ECIPQ). (3) Results: Clear relationships were found between the practice of physical activity and cybervictimisation. However, less involvement has been observed among girls who practice physical activity in cyberaggression. (4) Conclusions: In relation to the types of physical activity, it seems that practising physical activities that involve competition can help to develop defence mechanisms against cyberaggression, as well as improve values to be less involved in cyberaggression

Fatores que atingem no desmame precoce numa turma de mães de Santa Marta, na Colômbia

La lactancia materna es la forma ideal de aportar a los niños los nutrientes necesarios para su adecuado crecimiento y desarrollo; sin embargo, muchos factores interrumpen dicha práctica, entre ellos el fenómeno conocido como destete precoz. Objetivo: identificar qué factores inciden para que se presente el destete temprano en un grupo de madres de niños inscritos a un programa de crecimiento y desarrollo de un centro de salud de Santa Marta, Colombia. Metodología: estudio descriptivo, de corte transversal, cuantitativo en el que se escogió de una población de 372 una proporción de 54 madres con niños menores o iguales a 24 meses, seleccionadas de forma intencional hasta completar la muestra. La información se recolectó utilizando un instrumento diseñado y validado por los investigadores, mediante el juicio de expertos y previa prueba piloto. Resultados: el 94,22 % suministró lactancia materna exclusiva a sus hijos; mientras que el 5,77 % no lo hizo. Los factores que influyeron en la suspensión de la lactancia materna fueron: falta de tiempo (36,54 %), producción insuficiente de leche (23,06 %), rechazo del bebé a la lactancia (17,51 %), decisión propia de la madre (15,38 %) e influencia familiar (7,69 %). Conclusión: los factores sociales, generalmente, influyen para que se presente el destete temprano; pero la modificación se relaciona con aspectos culturales arraigados como prácticas comunes y costumbres cotidianas. Por ello es necesario que las entidades educativas y de salud continúen realizando esfuerzos que transformen aquello que afecta el bienestar y la salud de diversas poblaciones.Breastfeeding is the ideal way to give children the nutrients needed for proper growth and development; however, many factors disrupt this practice, including the phenomenon known as early weaning. Objective: To identify what factors contribute to early weaning in a group of mothers of children enrolled in a program of growth and development of a health center in Santa Marta, Colombia. Materials and methods: descriptive, cross-sectional, quantitative study. The sample was comprised by 54 mothers with children less than or equal to 24 months chose from a total of 372 mothers, they were intentionally selected to complete the sample. The information was collected using a questionnaire designed by the researchers, using expert judgment and previous pilot. Results: 94.22% exclusively breastfed their children; while 5.77% did not. Factors that influenced the suspension of breastfeeding were lack of time (36.54%), insufficient milk production (23.06%), refusal of baby to breastfeeding (17.51%), Mother's own decision (15.38%) and family influence (7.69%). Conclusion: social factors generally influence early weaning; but the change is related to cultural aspects rooted as common practices and everyday habits. It is therefore necessary that educational and health institutions continue their efforts to transform that which affects the welfare and health of diverse populations.A aleitamento materno é a forma ideal de fornecer às criancinhas nutrientes necessários para o adequado crescimento e desenvolvimento; no entanto, muito fator interrompe tal prática, incluindo o fenômeno conhecido como desmame precoce. Objetivo: identificar quais os fatores que atingem para que houver desmame precoce numa turma de mães de crianças matriculadas em um programa de crescimento e desenvolvimento de um centro de saúde de Santa Marta, na Colômbia. Materiais e métodos: estudo descritivo, de corte transversal, quantitativo no que foi seleta amostra de 54 mães de uma população de 372 mães com crianças menores ou iguais a 24 meses, escolhidas de forma intencional até completar amostra. A informação foi coletada utilizando um instrumento desenhado e avaliado pelos pesquisadores, mediante parecer de peritos e prévio teste piloto. Resultados: o 94,22 % ministrou amamentação exclusiva aos filhos; enquanto que o 5,77 % não fez assim. Os fatores que influíram na suspensão do aleitamento materno foram: falta de tempo (36,54 %), produção insuficiente de leite (23,06 %), o bebê recusou o aleitamento (17,51 %), decisão própria da mãe (15,38 %) e influência familiar (7,69 %). Discussão e conclusão: os fatores sociais, geralmente, influenciam para o desmame precoce acontecer; mais a alteração é relacionada com aspectos culturais arraigados como práticas comuns e costumes cotidianas. Por isso é preciso que as entidades educativas e de saúde continuem a realizar esforços paratransformar aquilo que afeta o bem-estar e a saúde de diversas populaçõe

Fatores que atingem no desmame precoce numa turma de mães de Santa Marta, na Colômbia

La lactancia materna es la forma ideal de aportar a los niños los nutrientes necesarios para su adecuado crecimiento y desarrollo; sin embargo, muchos factores interrumpen dicha práctica, entre ellos el fenómeno conocido como destete precoz. Objetivo: identificar qué factores inciden para que se presente el destete temprano en un grupo de madres de niños inscritos a un programa de crecimiento y desarrollo de un centro de salud de Santa Marta, Colombia. Metodología: estudio descriptivo, de corte transversal, cuantitativo en el que se escogió de una población de 372 una proporción de 54 madres con niños menores o iguales a 24 meses, seleccionadas de forma intencional hasta completar la muestra. La información se recolectó utilizando un instrumento diseñado y validado por los investigadores, mediante el juicio de expertos y previa prueba piloto. Resultados: el 94,22 % suministró lactancia materna exclusiva a sus hijos; mientras que el 5,77 % no lo hizo. Los factores que influyeron en la suspensión de la lactancia materna fueron: falta de tiempo (36,54 %), producción insuficiente de leche (23,06 %), rechazo del bebé a la lactancia (17,51 %), decisión propia de la madre (15,38 %) e influencia familiar (7,69 %). Conclusión: los factores sociales, generalmente, influyen para que se presente el destete temprano; pero la modificación se relaciona con aspectos culturales arraigados como prácticas comunes y costumbres cotidianas. Por ello es necesario que las entidades educativas y de salud continúen realizando esfuerzos que transformen aquello que afecta el bienestar y la salud de diversas poblaciones.Breastfeeding is the ideal way to give children the nutrients needed for proper growth and development; however, many factors disrupt this practice, including the phenomenon known as early weaning. Objective: To identify what factors contribute to early weaning in a group of mothers of children enrolled in a program of growth and development of a health center in Santa Marta, Colombia. Materials and methods: descriptive, cross-sectional, quantitative study. The sample was comprised by 54 mothers with children less than or equal to 24 months chose from a total of 372 mothers, they were intentionally selected to complete the sample. The information was collected using a questionnaire designed by the researchers, using expert judgment and previous pilot. Results: 94.22% exclusively breastfed their children; while 5.77% did not. Factors that influenced the suspension of breastfeeding were lack of time (36.54%), insufficient milk production (23.06%), refusal of baby to breastfeeding (17.51%), Mother's own decision (15.38%) and family influence (7.69%). Conclusion: social factors generally influence early weaning; but the change is related to cultural aspects rooted as common practices and everyday habits. It is therefore necessary that educational and health institutions continue their efforts to transform that which affects the welfare and health of diverse populations.A aleitamento materno é a forma ideal de fornecer às criancinhas nutrientes necessários para o adequado crescimento e desenvolvimento; no entanto, muito fator interrompe tal prática, incluindo o fenômeno conhecido como desmame precoce. Objetivo: identificar quais os fatores que atingem para que houver desmame precoce numa turma de mães de crianças matriculadas em um programa de crescimento e desenvolvimento de um centro de saúde de Santa Marta, na Colômbia. Materiais e métodos: estudo descritivo, de corte transversal, quantitativo no que foi seleta amostra de 54 mães de uma população de 372 mães com crianças menores ou iguais a 24 meses, escolhidas de forma intencional até completar amostra. A informação foi coletada utilizando um instrumento desenhado e avaliado pelos pesquisadores, mediante parecer de peritos e prévio teste piloto. Resultados: o 94,22 % ministrou amamentação exclusiva aos filhos; enquanto que o 5,77 % não fez assim. Os fatores que influíram na suspensão do aleitamento materno foram: falta de tempo (36,54 %), produção insuficiente de leite (23,06 %), o bebê recusou o aleitamento (17,51 %), decisão própria da mãe (15,38 %) e influência familiar (7,69 %). Discussão e conclusão: os fatores sociais, geralmente, influenciam para o desmame precoce acontecer; mais a alteração é relacionada com aspectos culturais arraigados como práticas comuns e costumes cotidianas. Por isso é preciso que as entidades educativas e de saúde continuem a realizar esforços paratransformar aquilo que afeta o bem-estar e a saúde de diversas populaçõe