Caracterización morfológica e histoquímica de las células del riñón cefálico, sangre y exudado peritoneal de lubina (dicentrarchus labrax L.): estudio "in vitro" de la capacidad fagocítica de sus leucocitos / María de los Angeles Esteban Abad ; director José Meseguer Peñalver.

Tesis-Universidad de Murcia.Consulte la tesis en: BCA. GENERAL. ARCHIVO UNIVERSITARIO. T.M.-714

Review of inflammation in fish and value of the zebrafish model

© 2020. This manuscript version is made available under the [CC-BY-NC-ND 4.0] license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Accepted Manuscript version of a Published Work that appeared in final form in [JOURNAL OF FISH DISEASES]. To access the final edited and published work see [10.1111/jfd.13310

Towards a new generation of vaccines: the cytokine IL-12 as an adjuvant to enhance cellular immune responses to pathogens during prime-booster vaccination regimens

A main goal of the industrialized world is the development of effective vaccines to control infectious diseases with major health and socio-economic impact. Current understanding of the immune response triggered during infection with pathogens causing malaria, hepatitis C and AIDS emphasizes the importance of cytotoxic T lymphocytes (CTLs) in combating these infections. This has led to the development of new vaccination strategies, some of which are in phase I/II clinical trials. Promising strategies of vaccination are based on highly attenuated vira1 vectors, such as Vaccinia virus (W) in combination with heterologous like vectors naked DNA, referred to as priming/booster vaccination. While these immunization schedules increased the production of specific CTLs, there is a need to further expand the CD8+T cell population to control an infection. Among molecules that play a significant role in the modulation of the CTL response is the cytokine IL-12. Immunoregulation by IL-12 is of central importance in cell-mediated immunity (CMI) against those pathogens and tumors that are controlled by cell-mediated mechanisms, supported by Thl cells. The use of this cytokine in combination with highly immunogenic W-derived vectors is a promising system for development of future vaccination schedules. In this review, we summarize recent data on the use of IL-12 in vaccination procedures, as well as undesired side-effects of the cytokine that can be overcome by accurate use of dose, route and time-window administration of IL-12 encoding vectors. Results described here indicate that VV IL12-mediated enhancement of the specific CM1 response against a model antigen HIV-1 env was timeand dose-dependent and that the antigen and the cytokine could be expresed from two different rVVs modulating the doses of the vectors and allowing for enhancement of a specific CM1 response. Moreover, the use of IL-12 during DNA prime/VV boost regimens enhanced the specific anti-HIV-1 env cellular response 20 times compared to that generated after a single rWenv inoculation. Variables such as: a) dose of the cytokine applied, b) time of its administration and c) routes of inoculation play a critica1 role in the final outcome of the response. The findings presented here can be extended to other antigens, suggesting that immunomodulatory cytokines can be useful in the development of the future vaccines against numerous infectious diseases and tumors

Modulación del sistema inmunitario de dorada (Sparus Aurata L.) mediante vitaminas suministradas en dieta : efecto sobre el estrés / Jesús Ortuño Sánchez ; directores José Meseguer Peñalver, Mª de los Angeles Esteban Abad.

Tésis-Universidad de Murcia.Consulte la tesis en: BCA. GENERAL. Fac. Veterinaria. Departamentos. E002B TESIS 91.Consulte la tesis en: BCA. GENERAL. DEPOSITO. T.M-2109

Estudio microscópico del riñón cefálico y de las células sanguíneas de la seriola (Seriola Dumerilii, Risso 1810) / Manuela Bernal Albarracín ; directores José Meseguer Peñalver, Mª de los Angeles Esteban Abad.

Tesis-Universidad de Murcia.Consulte la tesis en: BCA. GENERAL. Fac. Veterinaria. Departamentos. E002B TESIS 87.Consulte la tesis en: BCA. GENERAL. ARCHIVO UNIVERSITARIO. D 599.Consulte la tesis en: BCA. GENERAL. DEPOSITO. T.M-2021

Radiological characterization of gilthead seabream (Sparus aurata) fat by X -ray micro-computed tomography

© 2020. This manuscript version is made available under the [CC-BY 4.0] license http://creativecommons.org/licenses/by/4.0/ This document is the Accepted Manuscript version of a Published Work that appeared in final form in [Scientific Reports]. To access the final edited and published work see [https://doi.org/10.1038/s41598-020-67435-2

Effect of the administration of date palm seeds (Phoenix dactylifera L.) in gilthead seabream (Sparus aurata L.) diets

©. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Published Manuscript version of a Published Work that appeared in final form in [Journal of Agricultural Science& Crop Research]

In vitro and in vivo effects of purslane (Portulaca oleracea L.) on gilthead seabream (Sparus aurata L.)

©. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This document is the Published Manuscript version of a Published Work that appeared in final form in [AIMS Agriculture and Food ]. To access the final edited and published work see [10.3934/agrfood.2020.4.79