6-Biphenyl-Ester-3H-Naphtho[2,1-b]pyrans as Photochromic Dichroic Dyes and Optical Articles Containing Them

(EN)A naphthopyran compound represented by the formula (I) wherein: n1, n2, p, m and q represent an integer; R1, R2 and R4, represent a group selected from halogen, -Ra, -OH, -ORa, -SH, -SRa, -NH2, -NRaRa1, -NRbRc, -CO-Ra, -CO2Ra1, -OC(O)-Rd, -X-(Re)-Y, linear or branched (C1-C18) perfluoroalkyl group, wherein Ra, Ra1, Rb, Rc, X, Y, Re, and Rd are as defined in the description; Z represents a group selected from CO, CS, SO, SO2, CO2, C(O)S, CS2, C(O)NH, C(O)NRa, C(S)NH, C(S)NRa and C=NRa; R3 represents a group selected from halogen, -Ra, linear or branched (C1-18) perfluoroalkyl group -OH, -ORa, -SH, -SRa, -NH2, and -NRaRa1; R6 represents a group selected from -Ra which may be optionally substituted, linear or branched (C1-18) perfluoroalkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl, which may be optionally substituted; R5 represents a group selected from: halogen, -Ra, linear or branched (C1-18) perfluoroalkyl group, -OH, -ORa, -SH, -SRa, -NH2, -NRaRa1, -CO-Ra, -O-C(O)-Ra and -CO2Ra1; or when q is equal to 2, then two R5 together represents further a group -O-(CH2)q1-O- wherein q1 represents an integer comprised from 1 to 3 inclusive

Photochromic Dichroic Naphthopyrans and Optical Articles Containing them

(EN)A naphthopyran compound represented by the formulae (I) to (II) wherein : ▪ mi, Hi2, p, q are each an integer comprised from O to 4 or 5 inclusive; ▪ Ri, R2 and R4, represent a group selected from halogen, H, -Ra, aryl, -OH, -ORa, -SH, -SRa, -NH2, -NR8RaI, -NRbRc, -NRalCORa, -NRaiCO(aryl), -NRai aryl, -N-aryfe, -N(aryl)CO(aryl), -CO-R3, -CO2R3I, -OC(O)-Rd, and -X-(Re)-Y, and linear or branched (Ci-Ci8) perfluoroalkyl group, wherein R3, Rai, Rb, Rc, X, Y, Re, Rd are as defined into the description; ▪ Zi re resent a group selected from: (formules) (FR)L'invention porte sur un composé naphtopyrane représenté par les formules (I) à (II) dans lesquelles : ▪ mi, Hi2, p, q sont chacun un entier compris entre 0 à 4 ou 5 inclus ; ▪ Ri, R2 et R4 représentent un groupe choisi parmi halogène, H, -Ra, aryle, -OH, -ORa, -SH, -SRa, -NH2, -NR8RaI, -NRbRc, -NRalCORa, -NRaiCO(aryle), -NRai aryle, -N-aryle, -N(aryl)CO(aryle), -CO-R3, -CO2R3I, -OC(O)-Rd et -X-(Re)-Y et un groupe perfluoroalkyle en C1-C18 linéaire ou ramifié, où R3, Rai, Rb, Rc, X, Y, Re, Rd sont tels que définis dans la description ; ▪ Zi représente un groupe choisi parmi : (formules)

3H-Naphtho[2,1-b]pyrans as Photochromic Dichroic Dyes and Optical Articles Containing Them

A naphthopyran compound represented by the formula (I): wherein: n1, n2, p, q is an integer comprised from 0 to 5 inclusive; m is an integer comprised from 0 to 4 inclusive; R1 and R2 represent a group selected from halogen, -Ra, -OH, -ORa, - SH, -SRa, -NH2, -NRaRa1, -NRbRc, -CO-Ra, and -CO2Ra1, wherein Ra, Ra1, Rb and Rc, are as defined in the description ; R3 represents a group selected from halogen, -Ra, -OH, -ORa, -SH, -SRa, -NH2, and -NraRa1; R4 represents a group selected from halogen, -Ra, -OH, -ORa, -SH, -SRa, -NH2, -NRaRa1, -CO-Ra, and -CO2Ra1; R5 represents a group selected from: o halogen, -Ra, -OH, -ORa, -SH, -SRa, -NH2, and -NRaRa1, wherein Ra and Ra1 are as defined hereinbefore, o or when q is equal to 2, then two R5 together represent further a group -O-(CH2)q1-O- wherein ql represents an integer comprised from 1 to 3 inclusive

Synthese et caracterisation de copolymeres hydrophiles utilises comme supports de medicaments. Etude du relargage in vitro. Application aux lentilles corneennes a usage therapeutique

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