New perspectives on a more-or-less familiar poverty index, with extensions

A particular scale-invariant index of poverty is subjected to careful analysis. This leads to a new perspective, not seen before, on the family of subgroup-consistent and scale-invariant poverty indices. Parametric families of new poverty indices are presented which offer the analyst a degree of flexibility in the choice of transfer sensitivity and distribution sensitivity which has not been available before now.Poverty measurement, Distributional properties.

Should fines depend on income?:A questionnaire study on values and institutions

How do we make sense of the cross-country heterogeneity in value judgments emerging from international surveys? Our study suggests that the answer needs to go beyond the adaptation of values to existing institutions and should tap into deeper beliefs. In our case, Finnish respondents do support their country's system of income-dependent fines more strongly than respondents in countries using a fixed fine system. However, they also hold different beliefs on the relationship between income and well-being and hence on the burdens imposed by fining offenders at different income levels. A further illustration is provided in the context of income taxation

Relative Deprivation and School Enrolment: Evidence from Mexico

Using a large dataset (2.9 million households), we provide solid evidence of relative deprivation as being a negative correlate of school enrolment in Mexico, absolute standard of living being controlled for. This result is robust to a number of specifications, and to the use of linear and less than linear indices of relative deprivation. In addition, we find that marginal effects of relative deprivation are stronger at higher standards of living and for older children

Relative deprivation: Measurement issues and predictive role for body image dissatisfaction

The study of how relative standing in the socioeconomic hierarchy affects health outcomes faces a number of challenges. Two critical issues are the choice of the indicator quantifying relative standard of living and the collinearity which typically arises when absolute standard of living is controlled for. We address these issues by taking into examination linear and concave measures of relative deprivation and by showing that collinearity can be lessened through manipulations of the measures’ formulae. Importantly, we argue that the two issues are intertwined and should be jointly considered by researchers. We illustrate the points above using nationally representative data from Mexico (N = 44,214) and studying relative deprivation as a predictor of body image dissatisfaction – a growing public health concern whose effects go well beyond eating disorders. Controlling for several individual characteristics, binary and multinomial logit regressions indicate relative deprivation as a risk factor for body image dissatisfaction. By conducting subsample analyses and by introducing an interaction term between gender and relative deprivation, we show evidence of a gender-based heterogeneity in the role of relative deprivation – which predicts feeling smaller than desired for both females and males and feeling larger than desired for females but not for males. This heterogeneity is discussed in the light of the different social pressures females and males face for slenderness and muscularity. Our evidence enriches the literature on socioeconomic gradients in health, pointing to an additional domain in which a low position in the socioeconomic ladder translates into greater likelihood of developing health problems and adopting health-compromising behaviors

Chronic and Late Poverty as the Main Concerns in a Twofold Survey on Intertemporal Poverty Preferences

The increasing attention gained by the intertemporal aspect of poverty has led to the flourishing of measurement tools which are informed by conflicting views on deprivation dynamics. We test individual preferences for alternative intertemporal poverty patterns using primary data from a sample of 1,083 undergraduate students and a heterogeneous sample of 310 adults in the Dominican Republic. For both samples the strongest concerns are chronic (rather than intermittent) and poverty in the second rather than in the first part of one’s life. Preferences are significantly affected by a duration-based between-subject randomly assigned treatment. Individual characteristics such as age and standard of living are significant predictors of respondents’ views

Measuring health burden without discriminating against the disabled

This paper addresses an ethical implication of some health metrics used for evaluating population health, with particular reference to the Disability Adjusted Life Year (DALY). Specifically, the paper considers the concern that, such measures may discriminate against the disabled. An analysis of this problem is offered, alongside the formulation of three principles upon which an alternative measure is developed –the Ethically Adjusted Life Year (EALY)

The importance of being earliest : birth order and educational outcomes along the socioeconomic ladder in Mexico

We study the effect of birth order on educational outcomes in Mexico using 2 million observations from the 2010 Census. We find that the effect of birth order is negative, and a variety of endogeneity and robustness checks suggest a causal interpretation of this finding. We then examine whether these effects vary across households’ economic status, and we find significant heterogeneity across absolute as well as relative standards of living, operationalized as household wealth and relative deprivation. Finally, we find that firstborns’ advantage is amplified when they are male, and in particular when other siblings are female

What gets them going? The effects of activation policies on personal change processes of unemployed youth.

Activation policies are widely adopted to encourage labour market participation of unemployed youth, and yet they are poorly understood and monitored with regard to the causal mechanisms unfolding through their implementation. Activation schemes are often based on the carrot-and-stick logic informed by microeconomic job search theory, but activation occurs through processes which are far more complex and comprises elements of career identity and capability development, among others. This paper is the first to provide an in-depth exploration of the processes of attitudinal and behavioural change experienced by unemployed youth over the course of their participation in different activation programmes. Seven phases of change emerged from the analysis, namely vocational availability, self-testing, self-knowledge, self-confidence, goal-orientation, vocational activity and perseverance. For each of these phases, we identify drivers of change from both within and outside the intervention sphere, and discuss them in their implications for research and practice

Does government spending affect income poverty? A meta-regression analysis

This paper presents the results of a meta-regression analysis of the relationship between government spending and income poverty, with a focus on low- and middle-income countries. Through a comprehensive search and screening process, we identify a total of 19 cross-country econometric studies containing 169 estimates of this relationship. We find that the size and direction of the estimated relationship are affected by a range of factors, most notably the composition of the sample used for estimation, the control variables included in the regression model, and the type of government spending. Overall, we find no clear evidence that higher government spending has played a significant role in reducing income poverty in low- and middle-income countries. This is consistent with the view that fiscal policy plays a much more limited redistributive role in developing countries, in comparison with OECD countries. In addition, we find that the relationship between government spending and poverty is on average less negative for countries in Sub-Saharan Africa, and more negative for countries in Eastern Europe and Central Asia, compared to other regions. We also find that the relationship is less negative for government consumption spending, in comparison with other sectors. Finally, we find some evidence indicating the possibility of publication bias

179. Helper-Dependent Adenovirus-Mediated Gene Transfer of an LDL Receptor/Transferrin Chimeric Protein Reduces Aortic Atherosclerosis in LDL Receptor-Deficient Mice

Familial hypercholesterolemia (FH) is a well-characterized genetic hyperlipidemia due in most of the cases to mutations in the LDL receptor (LDLR) gene; FH is characterized by elevated concentration of plasma LDL cholesterol (LDL-C) with consequent deposition of LDL-C in tendons, skin and arteries. Statins can lower cholesterol levels but are not effective in all patients whose prognosis is still quite poor. In the past, we have developed safe and effective gene-therapy strategies for hepatocytes transduction and consequent expression of anti-atherogenic proteins using PEGylated helper-dependent adenoviral (HD-Ad) vectors. We have recently devised a therapeutic strategy for reducing LDL using a secreted protein that can potentially be expressed in non-hepatic tissues used as bioreactors. At this aim, we developed an HD-Ad vector for the expression of the soluble form of the extracellular portion of the human LDLR fused with transferrin (LDLR/Tf). We evaluated the efficacy of LDLR/Tf in cellular models such as CHOldla7 in which we restored the cell ability to uptake of labeled LDL; subsequently, we administered intravenously 1X10E11 vp/kg of the HD-Ad vector expressing LDLR/Tf in LDLR-deficient mice and demonstrated the efficacy of the above-mentioned vector in reducing total and LDL cholesterol levels; in addition, expression of LDLR/Tf significantly reduced aortic atherosclerotic lesions in treated LDLR-deficient mice compared to controls 1.78±0.48 vs. 5.38±0.54 sq.mm.). We therefore demonstrated the efficacy of serum secretion of LDLR/Tf in reducing aortic atherosclerosis in FH mice. These results will allow the evaluation of HD-Ad vector-mediated expression of LDLR/Tf in non-hepatic tissues using alternative routes of administration in order to develop safer gene transfer protocol more compatible with clinical applications