Plain water consumption is associated with lower intake of caloric beverage: cross-sectional study in Mexican adults with low socioeconomic status

Fifteen level single phase multilevel inverter is constructed using power circuit consist of 7 MOSFETs, seven independents DC sources, seven diodes, and an H-Bridge circuit. Switching method used in this MLI is sinusoidal pulse width modulation (SPWM) multicarrier where the reference wave in the form of a sinusoidal wave.  Multicarrier SPWM circuit is designed using electronic components such as Op-Amp that used as a comparator and some logic gates such as AND, OR and NOT gate to trigger S1, S2, S3, S4, S5, S6, S7, and H-Bridge circuit. Carrier waves used in this MLI modified from the triangle wave that having a frequency into carrier waves without frequency (DC sources) where THD that generated into 5.502%. While methods that use frequency such as Phase Disposition PWM (PD PWM), Phase Shift PWM (PS-PWM), and Carrier Overlapping PWM (CO PWM) that produces THD greater than the proposed method, this system was simulated using PSIM software. Abstract — Fifteen level single phase multilevel inverter is constructed using power circuit consist of 7 MOSFETs as switch, 7 indevendent DC sources, 7 diodes, and a H-Bridge. Trigering technic using sinusoidal pulse width modulation (SPWM) with 14 carrier wave, which pure sinusoidal wave as reference, SPWM circuit is disained using Op-Amp as comparator and some logic gates such as AND, OR and NOT gate in order to triggering S1, S2, S3, S4, S5, S6 and S7. By modificated carrier wave from triangular into DC source wave, this MLI produces THD output wave equal to 5.5019684%, while using methodes Phase Disposition PWM (PD PWM), Phase Shift PWM (PS PWM), and Carrier Overlapping PWM (CO PWM) produces THD more than proposed method, this system simulated using PSIM program. Keywords: Multilevel Inverter, SPWM, THD, PSI

Referencias para dinamometría manual en función de la estatura en edad pediátrica y adolescente

Antecedentes y objetivo: La dinamometría de la mano es una prueba funcional recomendada en la evaluación nutricional. Suele expresarse en función de la edad pero durante el crecimiento, incluso a la misma edad, varía el tamaño corporal. El objetivo del presente trabajo es aportar referencias de la fuerza de la mano en función de la talla. Sujetos y método: La muestra consta de 1.798 escolares entre 6 y 15 años. Se midió la talla, el peso y la fuerza de ambas manos. La dinamometría media (DM) se expresó en función de la estatura y se obtuvieron ecuaciones predictivas. La estadística descriptiva, comparativa y el análisis de regresión se efectuaron con el SPSS 21.0 Resultados: Se aportan referencias percentilares para la DM por categorías de talla en rangos de 5 cm. Las fórmulas obtenidas a partir del modelo de regresión (varones: DM = 0,207*peso + 0,621*talla – 71,461; mujeres DM=0,258*peso + 0,394*talla – 43,967) fueron validadas con la mitad de la muestra. Conclusiones: Las ecuaciones predictivas que se aportan en este trabajo permiten estimar la DM a partir del peso y la estatura con independencia de la edad

Referencias para dinamometría manual en función de la estatura en edad pediátrica y adolescente

Antecedentes y objetivo: La dinamometría de la mano es una prueba funcional recomendada en la evaluación nutricional. Suele expresarse en función de la edad pero durante el crecimiento, incluso a la misma edad, varía el tamaño corporal. El objetivo del presente trabajo es aportar referencias de la fuerza de la mano en función de la talla. Sujetos y método: La muestra consta de 1.798 escolares entre 6 y 15 años. Se midió la talla, el peso y la fuerza de ambas manos. La dinamometría media (DM) se expresó en función de la estatura y se obtuvieron ecuaciones predictivas. La estadística descriptiva, comparativa y el análisis de regresión se efectuaron con el SPSS 21.0 Resultados: Se aportan referencias percentilares para la DM por categorías de talla en rangos de 5 cm. Las fórmulas obtenidas a partir del modelo de regresión (varones: DM = 0,207*peso + 0,621*talla – 71,461; mujeres DM=0,258*peso + 0,394*talla – 43,967) fueron validadas con la mitad de la muestra. Conclusiones: Las ecuaciones predictivas que se aportan en este trabajo permiten estimar la DM a partir del peso y la estatura con independencia de la edad

Measuring the yield stress in magnetorheological fluids using ultrasounds

International audienceIn this work, we propose a new method to accurately determine the yield stress in magnetorheological (MR) fluids using ultrasounds. The setup is constructed and experimental data are obtained on a model conventional MR fluid under steady shear stress ramp-up tests. By using video-microscopy, ultrasonic techniques and rheometry, simultaneously, it is possible to precisely determine the yield stress at experimentally accessible times

La estructura metálica del casino «Gran Madrid», Torrelodones/Madrid/España

Described in this article is the structural solution in metal adopted in the upper levels of the building of the Casino «Gran Madrid». The principal deck pieces have been resolved in the form of triangulated trusses of elevated height slightly variable, with a triangulation system of simple Warren type. The supports of such beams are of ferruled neoprene. The Pratt disposition has been generally chosen for the other beams. The rest of the lintels, as likewise the supports, are formed by laminated outlines in their various forms.Se describe en este artículo la solución estructural metálica adoptada en los niveles superiores del edificio del Casino «Gran Madrid». Las piezas principales de cubierta se han resuelto en forma de vigas trianguladas de canto elevado, ligeramente variable, con un sistema de triangulación del tipo Warren simple. Los apoyos de dichas vigas son de neopreno zunchado. La disposición Pratt ha sido la comúnmente escogida para las demás vigas. El resto de los dinteles, así como los soportes, están formados por perfiles laminados en sus distintas variantes

Correlación entre unidades asta-concentración carotenoide en pimentones. Predicción de la estabilidad del color durante el almacenamiento

Paprika obtained through the traditional process, from fruits dried in oak ovens, is stored at room temperature for 18 months. Samples are taken at 2-3 months time intervals and color quantity is evaluated, measuring it as ASTA units and carotenoid content. Values obtained from both measurements are compared, achieving a good correlation between ASTA units and total carotenoid content. As a result two equations are proposed, one linking both parameters and another which predicts the remaining ASTA unit as a function of storage time. ASTA values after 18 months of storing time are ca. 55 % of the initial values.El pimentón obtenido de forma tradicional, a partir de frutos secados en hornos de leña, se ha almacenado a temperatura ambiente durante 18 meses. Se han tomado muestras de los mismos a intervalos de 2-3 meses y se ha evaluado la cantidad de color extractable como unidades ASTA y, en paralelo, se ha controlado la concentración carotenoide. Se comparan los valores obtenidos por cada uno de los dos procedimientos, observándose que se da una buena correlación entre las unidades ASTA y la concentración total de carotenoides. Se postula una ecuación que relaciona ambos parámetros y otra ecuación que permite predecir el valor remanente de ASTA con el tiempo de conservación. La retención de color a los 18 meses se sitúa en torno al 55 % del valor inicial

Exploring the Valuable Carotenoids for the Large-Scale Production by Marine Microorganisms

Carotenoids are among the most abundant natural pigments available in nature. These pigments have received considerable attention because of their biotechnological applications and, more importantly, due to their potential beneficial uses in human healthcare, food processing, pharmaceuticals and cosmetics. These bioactive compounds are in high demand throughout the world; Europe and the USA are the markets where the demand for carotenoids is the highest. The in vitro synthesis of carotenoids has sustained their large-scale production so far. However, the emerging modern standards for a healthy lifestyle and environment-friendly practices have given rise to a search for natural biocompounds as alternatives to synthetic ones. Therefore, nowadays, biomass (vegetables, fruits, yeast and microorganisms) is being used to obtain naturally-available carotenoids with high antioxidant capacity and strong color, on a large scale. This is an alternative to the in vitro synthesis of carotenoids, which is expensive and generates a large number of residues, and the compounds synthesized are sometimes not active biologically. In this context, marine biomass has recently emerged as a natural source for both common and uncommon valuable carotenoids. Besides, the cultivation of marine microorganisms, as well as the downstream processes, which are used to isolate the carotenoids from these microorganisms, offer several advantages over the other approaches that have been explored previously. This review summarizes the general properties of the most-abundant carotenoids produced by marine microorganisms, focusing on the genuine/rare carotenoids that exhibit interesting features useful for potential applications in biotechnology, pharmaceuticals, cosmetics and medicine.This work was funded by a research grant from the MINECO Spain (CTM2013-43147-R)

Optimization of Growth and Carotenoid Production by Haloferax mediterranei Using Response Surface Methodology

Haloferax mediterranei produces C50 carotenoids that have strong antioxidant properties. The response surface methodology (RSM) tool helps to accurately analyze the most suitable conditions to maximize C50 carotenoids production by haloarchaea. The effects of temperature (15–50 °C), pH (4−10), and salinity (5–28% NaCl (w/v)) on the growth and carotenoid content of H. mediterranei were analyzed using the RSM approach. Growth was determined by measuring the turbidity at 600 nm. To determine the carotenoid content, harvested cells were lysed by freeze/thawing, then re-suspended in acetone and the total carotenoid content determined by measuring the absorbance at 494 nm. The analysis of carotenoids was performed by an HPLC system coupled with mass spectrometry. The results indicated the theoretical optimal conditions of 36.51 or 36.81 °C, pH of 8.20 or 8.96, and 15.01% or 12.03% (w/v) salinity for the growth of haloarchaea (OD600 = 12.5 ± 0.64) and production of total carotenoids (3.34 ± 0.29 mg/L), respectively. These conditions were validated experimentally for growth (OD600 = 13.72 ± 0.98) and carotenoid production (3.74 ± 0.20 mg/L). The carotenoid profile showed four isomers of bacterioruberin (89.13%). Our findings suggest that the RSM approach is highly useful for determining optimal conditions for large-scale production of bacterioruberin by haloarchaea.This research has received funding from the Ministerio de Economía y Competitividad (Grant CTM2013–43147-R) of Spain

State of emergency medicine in Spain

Spain has universal public health care coverage. Emergency care provisions are offered to patients in different modalities and levels according to the characteristics of the medical complaint: at primary care centers (PCC), in an extrahospital setting by emergency medical services (EMS) and at hospital emergency departments (ED). We have more than 3,000 PCCs, which are run by family doctors (general practitioners) and pediatricians. On average, there is 1 PCC for every 15,000 to 20,000 inhabitants, and every family doctor is in charge of 1,500 to 2,000 citizens, although less populated zones tend to have lower ratios. Doctors spend part of their duty time in providing emergency care to their own patients. While not fully devoted to emergency medicine (EM) practice, they do manage minor emergencies. However, Spanish EMSs contribute hugely to guarantee population coverage in all situations. These EMS are run by EM technicians (EMT), nurses and doctors, who usually work exclusively in the emergency arena. EDs dealt with more than 25 million consultations in 2008, which implies, on average, that one out of two Spaniards visited an ED during this time. They are usually equipped with a wide range of diagnostic tools, most including ultrasonography and computerized tomography scans. The academic and training background of doctors working in the ED varies: nearly half lack any structured specialty residence training, but many have done specific master or postgraduate studies within the EM field. The demand for emergency care has grown at an annual rate of over 4% during the last decade. This percentage, which was greater than the 2% population increase during the same period, has outpaced the growth in ED capacity. Therefore, Spanish EDs become overcrowded when the system exerts minimal stress. Despite the high EM caseload and the potential severity of the conditions, training in EM is still unregulated in Spain. However, in April 2009 the Spanish Minister of Health announced the imminent approval of an EM specialty, allowing the first EM resident to officially start in 2011. Spanish emergency physicians look forward to the final approval, which will complete the modernization of emergency health care provision in Spain

Transmitted drug resistance to antiretroviral drugs in Spain during the period 2019–2021

To evaluate the prevalence of transmitted drug resistance (TDR) to nucleoside and nonnucleoside reverse transcriptase inhibitors (NRTI, NNRTI), protease inhibitors (PI), and integrase strand transfer inhibitors (INSTI) in Spain during the period 2019-2021, as well as to evaluate transmitted clinically relevant resistance (TCRR) to antiretroviral drugs. Reverse transcriptase (RT), protease (Pro), and Integrase (IN) sequences from 1824 PLWH (people living with HIV) were studied. To evaluate TDR we investigated the prevalence of surveillance drug resistance mutations (SDRM). To evaluate TCRR (any resistance level >= 3), and for HIV subtyping we used the Stanford v.9.4.1 HIVDB Algorithm and an in-depth phylogenetic analysis. The prevalence of NRTI SDRMs was 3.8% (95% CI, 2.8%-4.6%), 6.1% (95% CI, 5.0%-7.3%) for NNRTI, 0.9% (95% CI, 0.5%-1.4%) for PI, and 0.2% (95% CI, 0.0%-0.9%) for INSTI. The prevalence of TCRR to NRTI was 2.1% (95% CI, 1.5%-2.9%), 11.8% for NNRTI, (95% CI, 10.3%-13.5%), 0.2% (95% CI, 0.1%-0.6%) for PI, and 2.5% (95% CI, 1.5%-4.1%) for INSTI. Most of the patients were infected by subtype B (79.8%), while the majority of non-Bs were CRF02_AG (n = 109, 6%). The prevalence of INSTI and PI resistance in Spain during the period 2019-2021 is low, while NRTI resistance is moderate, and NNRTI resistance is the highest. Our results support the use of integrase inhibitors as first-line treatment in Spain. Our findings highlight the importance of ongoing surveillance of TDR to antiretroviral drugs in PLWH particularly with regard to first-line antiretroviral therapy