Evaluation of Temperature & Solvent Effect on Peach Kernel Oil Extraction & Determination & Quantification of Its Fatty

In this paper by using the most modern extraction technology, digital Soxhelet was used to extract peach kernel oil. Temperature, concentration of solvents could be adjustable by this gadget & in a controllable condition extraction could be done. Extraction was performed with Hexan & Ethanol solvents & Hexan’s yield extracts were higher than Ethanol ones. To consider more, Hexan extraction was focused & with three different temperatures & 4 amounts of solvents, yield extracts were determined. As a result, increasing in temperature & concentration of solvent will lead to induction of yield extracts. In addition to digital Soxhelet extraction method, quantity of oil extraction by non-heating method (maceration in solvent) at room temperature was discussed & showed lower extraction to Soxhelet extraction. After considering amount & quantity of peach kernel oil, quality of oil was studied by defining fatty acids compositions of peach kernel oil. Using GC device, twelve fatty acids’ compositions were determined. Maximum amounts were for Oleic & Linoleic acids. Finally some routine experiments were done to find out more about different values & indexes of peach kernel oil. Keywords: oil extraction, fatty acids, Soxhelet, Gas chromatograph

Introduced the ITGB1-DT as a novel biomarker associated with five potential drugs using bioinformatics analysis of breast cancer proteomics data and RT-PCR

Background: Breast cancer (BC) has been identified as a significant contributor to the rising number of female cancer deaths. As, it has become clear that breast cancer development depends on the interplay of several biological factors against a single molecule. This research aimed to use proteomics to gain a regulatory and metabolic understanding of BC pathophysiology. Method: For the study, a breast cancer proteomics dataset was downloaded from ProteomeXchange and then analyzed by employing MaxQuant and Perseus. Functional enrichment analysis through Metascape and Cytoscape software showed DEPs related biomedical phenomena with potential abruption. The expression of selected lncRNA in terms of the highest connectivity parameters was then quantitatively assessed through RT-PCR in 30 tumor tissues of breast cancer patients, as compared to the adjacent healthy ones. Result: The results indicated that among the 3048 identified proteins, 1149 were differentially expressed, which could be mainly enriched in several key terms. Furthermore, the obtained findings revealed that ITGB1-DT was significantly overexpressed in tumor tissues. Moreover, we found five potential compounds that could be attributed to ITGB1-DT targets (ATN-161, Firategrast, SB-683698, dabigatran-etexilate, and tranexamic-acid). Conclusion: These analyses proposed that ITGB1-DT could be employed as a differentiated factor to identify breast tumor tissues in healthy samples. Besides this, Firategrast could be introduced as a potential remedial agent for breast cancer patients. Overall, from the analysis of a proteomics dataset, an integrative map was generated, and a novel biomarker that may have been implicated in the early detection of BC was introduced

Human monkeypox infection re-emerges amid the COVID-19 crisis: A review

Background: Monkeypox is a re-emerging viral disease that has recently negatively affected the lives of many people in different countries of the world and has caused many concerns. One of the concerns about this virus is that it will become a new pandemic in the context of the ongoing COVID-19 pandemic. While the world is still struggling with the COVID-19 pandemic, the newly emerging viral disease monkeypox first broke out in the United Kingdom on April 29, 2022, amid the coronavirus crisis. Methodology: This review was carried out by searching articles using the keywords monkeypox, epidemic, covid-19, and emerging infection in various databases and extraction of relevant data based on inclusion and exclusion criteria. Discussion: Considering that the monkeypox virus is the cause of acute infections in humans and animals, it can have many effects on the overall population structure and economic issues of a country and threaten the health of human and animal populations. It can spread via direct and indirect contact both between humans and humans and animals. Asymptomatic patients are also able to spread the disease. Now that routine human smallpox vaccination has discontinued and herd immunity is declining, new assessments of monkeypox are required. Furthermore, basic ecological studies are required to better understand the animal species involved in virus transmission and maintenance, as well as to influence future preventive actions. Therefore, knowing different aspects of this disease, its prevention, and treatment methods are quite important.   Conclusion: Although cases of this disease have been reported in many non-endemic countries of the world, and we should be prepared for its prevention and proper treatment but considering its slower transmission method it seems that this disease can be controlled and prevented much more easily than COVID-19