La producción audiovisual y la comunicación digital de proyectos musicales, durante la pandemia - Lima Sur 2022

La presente investigación presenta como objetivo determinar la relación, a modo de correlación, la producción audiovisual y la comunicación digital. El estudio se desarrolló bajo un enfoque cuantitativo, de tipo descriptivo correlacional y con un diseño trasversal en 200 colaboradores o trabajadores de proyectos musicales en lima este durante pandemia, para lo cual se realizaron dos cuestionarios respectivamente. En los resultados se evidencia en ambas variables un p-valor= 0.000 menor al nivel de significancia establecido (p < 0.05), es decir no exhiben una distribución normal. Aplicándose la evaluación estadística no paramétrica Rho de Spearman. En conclusión, el presente trabajo de investigación reafirma la teoría planteada desde un inicio

Latin American perspectives and the IT2017 curricular guidelines

The term information technology has many meanings for various stakeholders and continues to evolve. This discussion presents an overview of the developing curricular guidelines for rigorous, high quality, bachelor\u27s degree programs in information technology (IT), called IT2017. Panel participants will focus on Latin American academic and industry perspectives on IT undergraduate education. Discussion will seek to ascertain commonalities and differences between the current draft IT2017 report and perspectives from Latino/a professional and academic communities. It also addresses ways in which this endeavor contrasts with current practices in Latin America industry and academia

Turismo Fast y su aplicación en la ciudad de Turín a través de una cuenta de Instagram

A partir de este trabajo realizamos una investigación sobre una nueva tipología de turismo llamado Turismo Fast. Analizaremos diferentes tipologías de turismo como el turismo slow o el turismo de masas para poder explicar mejor esta nueva tipología de turismo que finalmente terminaremos definiendo como una subtipología del turismo urbano. Elaboraremos un inventario de recursos para poder catalogar los diferentes recursos de la ciudad y seleccionarlos según distintas variables que más tarde explicaremos.A través de una conceptualización de las diferentes ideas que conforman esta nueva tipología de turismo damos pie a la creación de una cuenta de Instagram enfocada a la práctica y difusión del Turismo Fast tomando como ejemplo la ciudad de Turín. Gracias a esta cuenta podremos ayudar al turista a mejorar su experiencia en la ciudad optimizando al máximo el tiempo que la visite.<br /

Factores influyentes en la fotopolimerización de resinas con diferentes tipos de cargas inorgánicas - Lima 2023

El presente trabajo de investigación tiene como propósito fundamental describir la influencia de la fotopolimerización en su aplicación sobre distintos tipos de resinas determinados por su carga inorgánica, mediante la realización de un estudio experimental, aplicativo, trasversal y prospectivo. Para lo cual se trabajó con un muestreo de 90 unidades de resina de carga resinosa, cerámica y circonio, a las que se aplicó diferentes intensidades de luz, diferentes tiempos y distancias, comparándolas entre sí. Los resultados demostraron que la resina de carga resinosa, es más rápida de sensibilizar con una media de 2.72 mm presentando mayor sensibilización, mientras que las resinas de carga cerámica y circonio, tuvieron un comportamiento similar con 2.67 mm y 2.69 mm respectivamente, así mismo en relación al tiempo, se determina que a mayor tiempo, mayor cantidad de resina sensibilizada, en cuanto a la distancia, el comportamiento es inverso, a mayor distancia, menor sensibilización así como requiere mayor intensidad de las fuentes de fotopolimerización. Conclusión: Se determinó que, para mejores efectos de polimerización, se requiere mejores fuentes de luz, menor distancia, y con la finalidad de mejorar la respuesta de la resina es conveniente aplicar mediante técnicas como la incremental o la llamada técnica sándwich

Evaluation platform for 5G vehicular communications

Cellular vehicle to everything (C-V2X) communications is presented as the cornerstone for next-generation connected vehicles. C-V2X can support efficient vehicle to vehicle and vehicle to infrastructure data transmission, and is said to be a key enabler of cooperative connected and automated mobility (CCAM). Performance of 5G New Radio (5G-NR) is expected to address bandwidth and delay requirements of services for autonomous vehicles. This is the theory and what particular research works have showed through simulation or limited prototypes. On the contrary, this work focuses on evaluating real 5G deployments (including 5G-NR) of network operators in CCAM scenarios, with particular emphasis on cross-border settings and service continuity under inter-operator handovers. The paper presents an evaluation platform to gather cross-layer measurements, homogenise results, perform comparative assessment of figures of merit, and calculate network and CCAM key performance indicators (KPIs). The platform is evaluated through implementing a use case for autonomous overtaking, involving two 5G-NR operator deployments at the Spanish-Portuguese border. Results reveal good network performances and correct operation of the service, thanks to 5G-NR and edge servers, although significant impact of handovers is detected on network and overtaking KPIs.This work has been supported by the grants EC 825496 (5G-MOBIX), funded by the European Commission; PID2020- 112675RBC41 (ONOFRE-3), funded by MCIN/AEI/10.13039/501100011033; RYC-2017-23823, funded by MCIN/AEI/10.13039/ 501100011033 and by “ESF Investing in your future”; PGE-MOVESSING-2019-000104 (MECANO), funded by the Spanish Ministry for the Ecological Transition and the Demographic Challenge; and RED2018-102585-T (Go2Edge), funded by the Spanish Ministry of Science, Innovation and Universities

Side switch frequency while masticating different chewing materials, and its relationship with other masticatory behaviors and sensory perceptions.

Objective: This cross-sectional study aimed to establish normative values for masticatory side switch (MSS) frequency in young Mexican adults and to assess the relationship between various indices and MSS frequency when masticating different chewing materials. Design: We enrolled 101 dentate adults and performed four masticatory assays that involved masticating different chewing materials (i.e., two-colored chewing gum, sweet cracker, salty cracker, and bread). Participants were asked to eat and swallow these foods and to chew the gum for 40 cycles and the following indices were determined: MSS index (MSSI), unilateral chewing index, chewing cycle duration, and number of cycles before terminal swallowing. The participants then rated perceived flavor intensity, salivary flow, and muscle fatigue during each trial. Results: The MSSI ranged from 0.03-0.06 (10th percentile) to 0.48-0.54 (90th percentile). A repeated-measures general linear model revealed a mean MSSI value of 0.28 (95 %CI, 0.25-0.30) adjusted by several factors. Male sex, soft food, and the last chewing period were associated with lower MSS frequency. Spearman's test showed a high correlation for the MSSI among the different foods. MSSI correlated negatively with the unilateral chewing index for each chewing material and with number of cycles for the sweet cracker. However, no significant correlation was detected between MSSI and sensory perception. Conclusions: In healthy dentate individuals, the mean MSS relative frequency is 25-30 % with an 80-central percentile of 5-50 % of the maximum possible side changes. Lower MSS frequencies were detected in men, when chewing soft food, and during the final chewing period

Tumor immune microenvironment modulation by cholesterol in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is considered one of the most aggressive tumors worldwide. The consumption of lipid-enriched diets, mainly high cholesterol, induces oxidative stress and chronic inflammation, leading to HCC progression. Moreover, fatty acids and cholesterol could display differential responses on immune cells inside the tumor immune microenvironment (TIME). Tumor-associated macrophages (TAMs) represent one of the most critical leukocytes in the tumor microenvironment (TME) displaying pro-tumoral responses and one of the mainly cholesterol donors to cancer cells. Immunotherapy or cholesterol regulators, alone or combined, would represent an effective strategy for HCC treatment. Nonetheless, steatotic etiology from non-alcoholic fatty liver disease (NAFLD)-HCC tumors has been unexpectedly resulting in highly aggressive behavior

The hepatocyte growth factor induces an anti-inflammatory and repairing response in the cholestasis-induced colon damage

Aim: Cholestasis remains a partially characterized disease. Evidence has been gained that it is a systemic disease that begins in the liver but significantly impacts other organs and systems such as the kidney, heart, and intestine, among others. One of the primary damage mechanisms is the generation of reactive oxygen species (ROS), which eventually leads to oxidative stress, impacting canalicular morphology and actin cytoskeleton changes that could worsen the problem. These characteristics are also observed in the kidney and intestine. The work focused on addressing the intestine effects of intrahepatic cholestasis induced by α-naphthyl isothiocyanate (ANIT) and the protective response of the hepatocyte growth factor (HGF). Methods: The 10- to 12-week-old CD1 male mice were treated with ANIT and then treated or not with HGF; intestine damage was addressed by histology, immunohistochemistry (IHC) of specific markers, oxidative stress, and apoptosis. Results: Results show changes in the intestine histology, particularly the colon and ileum, induced by the cholestasis. HGF treatment restored the histology presentation and reverted the oxidative damage, clearly indicating a healing response. This observation was supported by an increment in anti-inflammatory macrophages (CD163+) in the HGF treatment. Conclusions: The data prove that HGF induces a protective and repairing response in the intestine under cholestatic challenges

The MADS transcription factor XAL2/AGL14 modulates auxin transport during Arabidopsis root development by regulating PIN expression

Elucidating molecular links between cell-fate regulatory networks and dynamic patterning modules is a key for understanding development. Auxin is important for plant patterning, particularly in roots, where it establishes positional information for cell-fate decisions. PIN genes encode plasma membrane proteins that serve as auxin efflux transporters; mutations in members of this gene family exhibit smaller roots with altered root meristems and stem-cell patterning. Direct regulators of PIN transcription have remained elusive. Here, we establish that a MADS-box gene (XAANTAL2, XAL2/AGL14) controls auxin transport via PIN transcriptional regulation during Arabidopsis root development; mutations in this gene exhibit altered stem-cell patterning, root meristem size, and root growth. XAL2 is necessary for normal shootward and rootward auxin transport, as well as for maintaining normal auxin distribution within the root. Furthermore, this MADS-domain transcription factor upregulates PIN1 and PIN4 by direct binding to regulatory regions and it is required for PIN4-dependent auxin response. In turn, XAL2 expression is regulated by auxin levels thus establishing a positive feedback loop between auxin levels and PIN regulation that is likely to be important for robust root patterning.This work was supported by grants from CONACYT, México: Red Tematica de Investigacion: ‘Complejidad, Ciencia y Sociedad’ (124909; ERAB; BGP; AGA) and 81542 and 105678 (ERAB), 167705 (AGA), 152649 (MPS), 81433 (BGP), 177739 (SF) and 127957 (JGD), from PAPIIT-UNAM, IN204011-3 (BGP), IN229009-3 (ERAB), IN226510-3 (AGA), IB201212 (MPS), and IN204312 (JGD), from the Spanish Government BFU2012-33746 (SP) and from the National Science Foundation (NSF-IOS) 0820648 (ASM). ERAB acknowledges the support of the Miller Institute for Basic Research in Science, University of California, Berkeley while spending a sabbatical leave in the laboratory of Chelsea Specht at UC-B.Peer reviewe