1,194 research outputs found
Line and continuum radiative transfer modelling of AA Tau
We present photometric and spectroscopic models of the Classical T Tauri star
AA Tau. Photometric and spectroscopic variability present in observations of AA
Tau is attributed to a magnetically induced warp in the accretion disc,
periodically occulting the photosphere on an 8.2--day timescale. Emission line
profiles show signatures of both infall, attributed to magnetospherically
accreting material, and outflow. Using the radiative transfer code TORUS, we
have investigated the geometry and kinematics of AA Tau's circumstellar disc
and outflow, which is modelled here as a disc wind. Photometric models have
been used to constrain the aspect ratio of the disc, the offset angle of the
magnetosphere dipole with respect to the stellar rotation axis, and the inner
radius of the circumstellar disc. Spectroscopic models have been used to
constrain the wind and magnetosphere temperatures, wind acceleration parameter,
and mass loss rate. We find observations are best fitted by models with a mass
accretion rate of M yr, a dipole offset of
between and , a magnetosphere that truncates the disc from
5.2 to 8.8 R, a mass-loss-rate to accretion-rate ratio of ~ 0.1, a
magnetosphere temperature of 8500 -- 9000 K, and a disc wind temperature of
8000 K.Comment: 22 pages, 32 figures, 4 tables. Accepted by MNRAS. V3: Corrected typ
Structure, Scaling and Phase Transition in the Optimal Transport Network
We minimize the dissipation rate of an electrical network under a global
constraint on the sum of powers of the conductances. We construct the explicit
scaling relation between currents and conductances, and show equivalence to a a
previous model [J. R. Banavar {\it et al} Phys. Rev. Lett. {\bf 84}, 004745
(2000)] optimizing a power-law cost function in an abstract network. We show
the currents derive from a potential, and the scaling of the conductances
depends only locally on the currents. A numerical study reveals that the
transition in the topology of the optimal network corresponds to a
discontinuity in the slope of the power dissipation.Comment: 4 pages, 3 figure
Similarity theory and calculation of turbulent fluxes at the surface for the stably stratified atmospheric boundary layers
In this paper we revise the similarity theory for the stably stratified
atmospheric boundary layer (ABL), formulate analytical approximations for the
wind velocity and potential temperature profiles over the entire ABL, validate
them against large-eddy simulation and observational data, and develop an
improved surface flux calculation technique for use in operational models.Comment: The submission to a special issue of the Boundary-Layer Meteorology
devoted to the NATO advanced research workshop Atmospheric Boundary Layers:
Modelling and Applications for Environmental Securit
Impact of ivermectin administered for scabies treatment on the prevalence of head lice in Atoifi, Solomon Islands.
Scabies and head lice are ubiquitous ectoparasitic infestations that are common across the Pacific Islands. Ivermectin is an effective treatment for both conditions, although the doses used vary. At a community level, mass drug administration (MDA) with ivermectin is an effective strategy to decrease prevalence of scabies. To what extent MDA with ivermectin will also reduce prevalence of head lice is unknown.
Head lice prevalence was assessed before and after MDA with oral ivermectin (at a dose of 200 micrograms per kilogram of body weight) administered on day 1 and day 8. The primary outcome was the change in prevalence of head louse infestation at two weeks compared to baseline. Longer term efficacy was assessed three months after MDA.
118 participants were enrolled. Baseline prevalence of active head louse infestation was 25.4% (95% CI 18.4-34.0). At three-month follow-up, prevalence was 7.5% (95% CI 2.7-12.3), a relative reduction of 70.6% (95% CI 72.7%-91.4%, p <0.001). Head louse infestation was associated with younger age (age ≤10 years: prevalence 46.7%; adjusted odds ratio compared to adults of 7.2, 95%CI 2.0-25.9) and with having at least one other member of the household with active head louse infestation (adjusted odds ratio 4.3, 95%CI 1.7-11.1).
Head louse infestation is common in the Solomon Islands. This proof of principle study shows that oral ivermectin at a dose of 200 micrograms per kilogram can reduce the burden of active head louse infestation, offering an additional collateral benefit of MDA with ivermectin for scabies control.
ClinicalTrials.gov NCT03236168
An SREBP-Responsive microRNA Operon Contributes to a Regulatory Loop for Intracellular Lipid Homeostasis
SummarySterol regulatory element-binding proteins (SREBPs) have evolved as a focal point for linking lipid synthesis with other pathways that regulate cell growth and survival. Here, we have uncovered a polycistrionic microRNA (miRNA) locus that is activated directly by SREBP-2. Two of the encoded miRNAs, miR-182 and miR-96, negatively regulate the expression of Fbxw7 and Insig-2, respectively, and both are known to negatively affect nuclear SREBP accumulation. Direct manipulation of this miRNA pathway alters nuclear SREBP levels and endogenous lipid synthesis. Thus, we have uncovered a mechanism for the regulation of intracellular lipid metabolism mediated by the concerted action of a pair of miRNAs that are expressed from the same SREBP-2-regulated miRNA locus, and each targets a different protein of the multistep pathway that regulates SREBP function. These studies reveal an miRNA “operon” analogous to the classic model for genetic control in bacterial regulatory systems
When the path is never shortest: a reality check on shortest path biocomputation
Shortest path problems are a touchstone for evaluating the computing
performance and functional range of novel computing substrates. Much has been
published in recent years regarding the use of biocomputers to solve minimal
path problems such as route optimisation and labyrinth navigation, but their
outputs are typically difficult to reproduce and somewhat abstract in nature,
suggesting that both experimental design and analysis in the field require
standardising. This chapter details laboratory experimental data which probe
the path finding process in two single-celled protistic model organisms,
Physarum polycephalum and Paramecium caudatum, comprising a shortest path
problem and labyrinth navigation, respectively. The results presented
illustrate several of the key difficulties that are encountered in categorising
biological behaviours in the language of computing, including biological
variability, non-halting operations and adverse reactions to experimental
stimuli. It is concluded that neither organism examined are able to efficiently
or reproducibly solve shortest path problems in the specific experimental
conditions that were tested. Data presented are contextualised with biological
theory and design principles for maximising the usefulness of experimental
biocomputer prototypes.Comment: To appear in: Adamatzky, A (Ed.) Shortest path solvers. From software
to wetware. Springer, 201
Potent inhibition of microRNA in vivo without degradation
Chemically modified antisense oligonucleotides (ASOs) are widely used as a tool to functionalize microRNAs (miRNAs). Reduction of miRNA level after ASO inhibition is commonly reported to show efficacy. Whether this is the most relevant endpoint for measuring miRNA inhibition has not been adequately addressed in the field although it has important implications for evaluating miRNA targeting studies. Using a novel approach to quantitate miRNA levels in the presence of excess ASO, we have discovered that the outcome of miRNA inhibition can vary depending on the chemical modification of the ASO. Although some miRNA inhibitors cause a decrease in mature miRNA levels, we have identified a novel 2′-fluoro/2′-methoxyethyl modified ASO motif with dramatically improved in vivo potency which does not. These studies show there are multiple mechanisms of miRNA inhibition by ASOs and that evaluation of secondary endpoints is crucial for interpreting miRNA inhibition studies
Induction of microRNAs, mir-155, mir-222, mir-424 and mir-503, promotes monocytic differentiation through combinatorial regulation
Acute myeloid leukemia (AML) involves a block in terminal differentiation of
the myeloid lineage and uncontrolled proliferation of a progenitor state. Using
phorbol myristate acetate (PMA), it is possible to overcome this block in THP-1
cells (an M5-AML containing the MLL-MLLT3 fusion), resulting in differentiation
to an adherent monocytic phenotype. As part of FANTOM4, we used microarrays to
identify 23 microRNAs that are regulated by PMA. We identify four PMA-induced
micro- RNAs (mir-155, mir-222, mir-424 and mir-503) that when overexpressed
cause cell-cycle arrest and partial differentiation and when used in
combination induce additional changes not seen by any individual microRNA. We
further characterize these prodifferentiative microRNAs and show that mir-155
and mir-222 induce G2 arrest and apoptosis, respectively. We find mir-424 and
mir-503 are derived from a polycistronic precursor mir-424-503 that is under
repression by the MLL-MLLT3 leukemogenic fusion. Both of these microRNAs
directly target cell-cycle regulators and induce G1 cell-cycle arrest when
overexpressed in THP-1. We also find that the pro-differentiative mir-424 and
mir-503 downregulate the anti-differentiative mir-9 by targeting a site in its
primary transcript. Our study highlights the combinatorial effects of multiple
microRNAs within cellular systems.Comment: 45 pages 5 figure
Comportamiento de novillos bajo dos sistemas de alimentación melaza/urea vs grano de sorgo con la utilización de dos fuentes de proteína y forraje restringido
Se llevó a cabo un experimento para evaluar el efecto de la suplementación con dos fuentes proteicas (harinolina y pasta de girasol) al utilizar dietas altas en melaza/urea o grano de sorgo con forraje restringido en la alimentación de novillos en crecim
High Latitude Dynamics of Atmosphere-Ice-Ocean Interactions
Dynamics of atmosphere–ice–ocean interactions in the high latitudes. What: Scientists from 13 countries involved with modeling and observing the coupled high-latitude weather and climate system discussed our current understanding and challenges in polar prediction, extreme events, and coupled processes on scales ranging from cloud and turbulent processes, from micrometers and a few hundred meters to processes on synoptic-scale weather phenomena and pan-Arctic energy budgets of hundreds to thousands of kilometers. Workshop participants also evaluated research needs to improve numerical models with usages spanning from uncoupled to fully coupled models used for weather and climate prediction (http://highlatdynamics.b.uib.no/). When: 23–27 March 2015. Where: Rosendal, Norwa
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