An Immunomodulatory Peptide Dendrimer Inspired from Glatiramer Acetate

To identify an alternative to the polymeric peptide drug Glatiramer Acetate (GA) used to treat multiple sclerosis, we tested peptide dendrimers with a size and composition similar to that of GA for their ability to induce the release of the cytokine IL1-Ra from primary human monocytes. The best dendrimer is as active as GA and is shown by fluorescence labelling to internalize into monocytes and to trigger a distinct anti-inflammatory response