The synthesis and anticonvulsant activity of some ?-phthalimido-N- phenylacetamide and propionamide derivatives

PubMed ID: 14981667In this study, by combining anilide and N',N'- phthaloylglycinamide pharmacophores which are known to produce potent anticonvulsant compounds, sixteen ?-phthalimido-N-phenylacetamide and propionamide derivatives bearing substituents at positions 2 or 2,6 on N-phenyl ring have been synthesized. The structural confirmation of the title compounds was achieved by interpretation of spectral and analytical data. The anticonvulsant activity of the title compounds was determined against maximal electroshock seizure at 100 mg/kg dose level in mice. The preliminary screening results indicated that ?-phthalimido-N-phenylacetamide and propionamide nuclei have pronounced anticonvulsant activity against maximal electroshock seizure

Synthesis and anticonvulsant activity of some N-phenyl-2- phtalimidoethanesulfonamide derivatives

PubMed ID: 18038376In this study, inspired by the structures of the taltrimide, 2-phthalimidoethanesulphonamide, and the anilide pharmacophore known to be synthetically produced anticonvulsant compounds, fifteen N-phenyl-2- phtalimidoethanesulfonamide derivatives bearing substituents with diverse electronic and hydrophobic features on N-phenyl ring were synthesized. The structural confirmation of the title compounds was achieved by interpretation of spectral and analytical data. The anticonvulsant activity of the title compounds was determined against maximal electroshock seizure in mice at a dose level of 100 mg/kg. The preliminary screening results indicated that the exchange of the N-isopropyl moiety for an N-phenyl ring in the taltrimide molecule abolished the anticonvulsant activity. However, introducing certain substituents, such as nitro, methyl, and chloro, into the N-phenyl ring lead to more active compounds in comparison to the unsubstituted derivatives. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA

Synthesis and anticonvulsant activity of some ?-(1H-imidazol-1-yl)-N- phenylacetamide and propionamide derivatives

PubMed ID: 15262528In this study, eight new ?-(1H-imidazol-1-yl)-N-phenylacetamide and propionamide derivatives having 2,6-dimethyl, 2,6-dichloro, 2-chloro-6-methyl and 2-isopropyl substitutions on N-phenyl ring were synthesized to evaluate anticonvulsant activity against maximal electroshock test. The most active compounds in the series were the derivatives bearing 2-isopropyl and 2,6-dimethyl substituents on N-phenyl ring. © 2003 Elsevier SAS. All rights reserved.Ege Üniversitesi: 2000/Ecz/15 National Council for Scientific Research SBAG/AYD 359This study was supported by research grants from Ege University (project number: 2000/Ecz/15) and The Scientific and Technical Research Council of Turkey (TUBITAK; project number: SBAG/AYD 359). -

Personalized Hand Pose and Gesture Recognition System for the Elderly

Elderly population is growing all over the globe. Novel human-computer interaction systems and techniques are required to fill the gap between elderly reduced physical and cognitive capabilities and the smooth usage of technological artefacts densely populating our environments. Gesture-based interfaces are potentially more natural, intuitive, and direct. In this paper, we propose a personalized hand pose and gesture recognition system (called HANDY) supporting personalized gestures and we report the results of two experiments with both younger and older participants. Our results show that by sufficiently training our system we can get similar accuracies for both younger and older users. This means that our gesture recognition system can accommodate the limitations of an ageing-hand even in presence of hand issues like arthritis or hand tremor